Ji  Luo, Ph.D.

Ji Luo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 37, Room 4054B
  • Bethesda, MD 20892
  • 240-760-6931


Dr. Luo focuses the biology of cancer driven by the Ras oncogene. In particular, he aims to understand non-oncogene addiction mechanism that cooperates with the Ras oncogene to support tumor initiation, progression and metastasis. Research from his laboratory has identified multiple stress-response pathways that are critical for the survival of cancer cells. These discoveries could help the development of new therapeutic strategies for the treatment of Ras mutant tumors.

Areas of Expertise

Non-Oncogene Addiction and Synthetic Lethality
RNAi and CRISPR Screens, Mouse Cancer Models, Organoid Models


Selected Recent Publications

A Nonconserved Histidine Residue on KRAS Drives Paralog Selectivity of the KRASG12D Inhibitor MRTX1133

Keats MA, Han JW, Lee Y-H, Lee C-S, Luo J
Cancer Research. 83(17): 2816-2823, 2023.
Full-Text Article
[ Journal Article ]

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Lee C-S, Lee LC, Yuan TL, Chakka S, Christof Fellmann C, Scott W. Lowe SW, Caplen NJ, Frank McCormick F, Luo J
PNAS. 116(10): 4508-4517, 2019.
Full-Text Article
[ Journal Article ]

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level

Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J
Nucleic Acids Research. 45(20): 12039-12053, 2017.
Full-Text Article
[ Journal Article ]

Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9

Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu DJ, Smith JL, Yuen G, Yue J, Ann D, Simpson RM, Creighton CJ, Figg WD, Gucek M, Luo J
PNAS. 112(14): E1724-33, 2015.
Full-Text Article
[ Journal Article ]

Development of siRNA payloads to target KRAS-mutant cancer

Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW
Cancer Discovery. 4(10): 1182-1197, 2014.
Full-Text Article
[ Journal Article ]

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Staff Scientist
Chih-Shia Lee, Ph.D.
Research Fellow
Haibo Zhang, Ph.D.
Postdoctoral Fellow (Visiting)
Yeon-Hwa Lee, Ph.D.
Postdoctoral Fellow (Visiting)
Wei-Chun Lee, Ph.D.


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