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Lalage M. Wakefield, D.Phil.

Lalage M. Wakefield, D.Phil.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Wakefield is a leading investigator in the complex cancer biology of the TGF-β pathway, with a particular focus on breast cancer. Her preclinical studies contributed to the development of anti-TGF-β therapeutics in oncology, some of which have advanced to early clinical trials. Her current research program uses innovative imaging, genomic and animal modeling methods to address the role of TGF-βs in regulating cancer stem cells, elucidate mechanisms underlying the dual role of TGF-β in cancer, and develop and exploit preclinical models to support the clinical development of TGF-β antagonists.

Areas of Expertise

1) TGF-β 2) breast cancer 3) metastasis 4) mouse models 5) targeted therapy 6) cancer stem cells

Publications

Selected Key Publications

The outcome of TGFβ antagonism in metastatic breast cancer models in vivo reflects a complex balance between tumor-suppressive and proprogression activities of TGFβ

Yang Y, Yang HH, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Ednondson EF, Simpson RM, Liu F, Liu H, Lee MP, Wakefield LM.
Clinical Cancer Research. 26(3): 643-656, 2020.
Full-Text Article
[ Journal Article ]

Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Sharma VP, Tang B, Wang Y, Duran CL, Karagiannis GS, Xue EA, Entenberg D, Borriello L, Coste A, Eddy RJ, Kim G, Ye X, Jones JG, Grunblatt E, Agi N, Roy S, Bandyopadhyaya G, Adler E, Surve CR, Esposito D, Goswami S, Segall JE, Guo W, Condeelis JS, Wakefield LM, Oktay MH.
Nature Communications. 12(1): 7300, 2021.
Full-Text Article
[ Journal Article ]

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR, Merlino G, Wakefield LM.
J. Clin. Invest.. 109: 1607-15, 2002.
Full-Text Article
[ Journal Article ]

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, Wakefield LM.
J. Clin. Invest.. 112: 1116-24, 2003.
Full-Text Article
[ Journal Article ]

A flexible reporter for direct observation of cancer stem cells

Tang B, Raviv A, Esposito D, Daniel C, Nghiem B-T, Garfield S, Lim L, Mannan P, Robles AI, Smith WI, Zimmerberg J, Ravin R, and Wakefield LM.
Stem Cell Reports. 4: 155-169, 2015.
Full-Text Article
[ Journal Article ]

Team

Research Biologist
Yuan Yang, M.D., Ph.D.
Postdoctoral Fellow (CBSTP)
Zachary Millman, D.V.M.
Postbaccalaureate Fellow (CRTA)
Zoya Khan, B.S.
Postbaccalaureate Fellow (iCURE)
Victoria Gonzalez, B.A.