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Binwu  Tang, Ph.D.

Binwu Tang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Tang's major research interest is focused on understanding molecular mechanisms the dual role of TGF-beta in breast cancer. Her current research program uses innovative imaging, genomic and animal modeling methods to address the role of TGF-betas in regulating breast cancer stem cells.

Areas of Expertise

1) TGF-beta, 2) breast cancer, 3) cancer stem cells

Publications

Selected Key Publications

A flexible reporter system for direct observation and isolation of cancer stem cells

Tang B, Raviv A, Esposito D, Flanders KC, Daniel C, Nghiem BT, Garfield S, Lim L, Mannan P, Robles AI, Smith WI Jr, Zimmerberg J, Ravin R, Wakefield LM.
Stem Cell Reports. 4: 155-69, 2015. [ Journal Article ]

Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

Tang B, Yoo N, Vu M, Mamura M, Nam JS, Ooshima A, Du Z, Desprez PY, Anver MR, Michalowska AM, Shih J, Parks WT, Wakefield LM.
Cancer Res. 67: 8643-52, 2007. [ Journal Article ]

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression

Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, Wakefield LM.
J Clin Invest. 112: 1116-24, 2003. [ Journal Article ]

Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells

Tang B, de Castro K, Barnes HE, Parks WT, Stewart L, Böttinger EP, Danielpour D, Wakefield LM.
Cancer Res. 59: 4834-42, 1999. [ Journal Article ]

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency

Tang B, Böttinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ, Wakefield LM.
Nat Med. 4: 802-7, 1998. [ Journal Article ]