Jonathan M. Hernandez, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 4-3752
- Bethesda, MD 20892
- 240-760-6076
- jonathan.hernandez@nih.gov
RESEARCH SUMMARY
Dr. Jonathan Hernandez is a surgical oncologist/HPB surgeon, chief of the surgical oncology section (Surgical Oncology Program/NCI/NIH), Associate Professor of Surgery (Uniformed Services University of the Health Sciences), and Clinical Professor of Surgery (George Washington University). He specializes in the treatment of liver metastases from colorectal cancer and neuroendocrine tumors, primary biliary tract cancers, as well as other complex abdominal tumors including recurrent and metastatic adrenocortical carcinoma. Dr. Hernandez’s research efforts focus on unveiling novel therapeutic vulnerabilities for these cancers, which enlist the use of locoregional drug delivery techniques. The Hernandez lab has developed and now implements ex-vivo human tumor systems using tissue directly from the operating room to provide an avenue of translationally relevant interrogation.
Board Certifications
American Board of Surgery: General Surgery
American Board of Surgery: Complex General Surgical Oncology
Areas of Expertise
Information for Patients
Learn more about Dr. Hernandez's clinical research team and clinical trials.
Jonathan M. Hernandez, M.D.
Clinical Trials
Research
Please see "View My Lab" tab above
Publications
- Bibliography Link
- View Dr. Hernandez's Complete Bibliography at NCBI.
Tumour exosome integrins determine organotropic metastasis
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues.
Biography
Jonathan M. Hernandez, M.D.
Dr. Hernandez graduated from medical school with honors from the University of Florida, and completed general surgery training at the University of South Florida. During his residency, Dr. Hernandez spent two years at the Moffitt Cancer Center and Research Institute interrogating molecular diagnostics for liver metastases and miRNA-mediated mechanisms of metastatic spread with the support of NIH funding. Following residency, Dr. Hernandez completed fellowship training in both surgical oncology and hepatopancreatobiliary surgery at Memorial Sloan Kettering Cancer Center. During his fellowships, Dr. Hernandez spent an additional two years in dedicated basic research studying metastatic colonization as a scholar in the Cell Biology Program of the Sloan Kettering Institute supported by NIH funding and a grant from America’s HepatoPancreatoBiliary Association. Dr. Hernandez was also a visiting investigator in the Cell and Developmental Biology Department of Weill Medical College of Cornell University studying metastatic niche evolution with funding support from the Conquer Cancer Foundation of the American Society of Clinical Oncology. Dr. Hernandez has authored over 150 peer-reviewed publications and has contributed book chapters in numerous authoritative surgical textbooks.
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