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Jonathan M. Hernandez, M.D.

Jonathan M. Hernandez, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Metastasis Biology Section
Chief, Surgical Oncology Section

RESEARCH SUMMARY

Dr. Jonathan Hernandez is a surgical oncologist/HPB surgeon, chief of the surgical oncology section (Surgical Oncology Program/NCI/NIH), Associate Professor of Surgery (Uniformed Services University of the Health Sciences), and Clinical Professor of Surgery (George Washington University). He specializes in the treatment of liver metastases from colorectal cancer and neuroendocrine tumors, primary biliary tract cancers, as well as other complex abdominal tumors including recurrent and metastatic adrenocortical carcinoma. Dr. Hernandez’s research efforts focus on unveiling novel therapeutic vulnerabilities for these cancers, which enlist the use of locoregional drug delivery techniques. The Hernandez lab has developed and now implements ex-vivo human tumor systems using tissue directly from the operating room to provide an avenue of translationally relevant interrogation. 

Board Certifications
American Board of Surgery: General Surgery
American Board of Surgery: Complex General Surgical Oncology

Areas of Expertise

Cholangiocarcinoma
Colorectal Cancer Liver Metastases
Neuroendocrine Tumor Liver Metastases and Recurrent/Metastatic Adrenocortical Carcinoma

Information for Patients

Learn more about Dr. Hernandez's clinical research team and clinical trials.

Research

Please see "View My Lab" tab above 

Publications

Selected Key Publications

Tumour exosome integrins determine organotropic metastasis

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D
Nature. 527(7578): 329-35, 2015. [ Journal Article ]

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei I, Peinado H, Stanger BZ, Bromberg J, Lyden D.
Nature Cell Biology. 17(6): 816-26, 2015. [ Journal Article ]

IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues.

Radtke AJ, Kandov E, Lowekamp B, Speranza E, Chu CJ, Gola A, Thakur N, Shih R, Yao L, Yaniv ZR, Beuschel RT, Kabat J, Croteau J, Davis J, Hernandez JM, Germain RN
Proceedings of the National Academy of Sciences of the United States of America. 117(52): 55-65, 2020.
Full-Text Article
[ Journal Article ]

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O'Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D.
Cell. 182(4): 1044-1061, 2020.
Full-Text Article
[ Journal Article ]

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW
Cancer Cell. 36 (4): 418-430, 2019.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Cathleen Hannah
Nurse Practitioner
Cathleen Hannah, N.P.
Kate Smith
Research Nurse
Kate Smith, R.N.
Rosie Melendez
Patient Care Coordinator
Rosie Miguel
Program Specialist
Joanna Lamot