Ramiro Iglesias-Bartolome, Ph.D.

Ramiro Iglesias-Bartolome, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Our laboratory studies the signal and transcriptional networks regulating epithelial proliferation and differentiation, primarily using skin as a model system. The skin epidermis is functionally divided into compartments maintained by stem and transit-amplifying progenitor cells. Environmental assaults and genomic abnormalities can result in the imbalance of the homeostatic functions of epithelial cells, leading to uncontrolled cell proliferation or elimination of tissue-regenerative cells by death, differentiation, or senescence. Understanding the pathways regulating these cell fates can provide essential insights into cancer initiation and a host of pathologies involving progressive loss of tissue-specific regenerating cells.

Areas of Expertise

Skin Epithelial Stem Cells, Keratinocytes
G Protein Coupled Receptors (GPCRs), Hedgehog Signaling
Basal Cell Carcinoma


Selected Key Publications

YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity.

Yao Yuan, Jeannie Park, Amber Feng, Parirokh Awasthi, Zhiyong Wang, Qianming Chen, and Ramiro Iglesias-Bartolome
Nature Communications. 11(1): 1472, 2020.
Full-Text Article
[ Journal Article ]

The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis

Pedro MP, Lund K, Iglesias-Bartolome R.
Stem Cells. 38: 1520– 1531, 2020.
Full-Text Article

Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth

Hoy JJ, Salinas Parra N, Park J, Kuhn S, Iglesias-Bartolome R.
FASEB J.. 34(10): 13900-13917, 2020.
Full-Text Article
[ Journal Article ]

Activation of G-Protein Coupled Receptor–Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia

M. Pilar Pedro, Natalia Salinas Parra, J. Silvio Gutkind and Ramiro Iglesias-Bartolome
Journal of Investigative Dermatology. S0022-202X(19)33386-X: 2019.
Full-Text Article
[ Journal Article ]

Transcriptional signature primes human oral mucosa for rapid wound healing

Ramiro Iglesias-Bartolome, Akihiko Uchiyama, Alfredo A Molinolo, Loreto Abusleme, Stephen R Brooks, Juan Luis Callejas-Valera, Dean Edwards, Colleen Doci, Marie-Liesse Asselin-Labat, Mark W Onaitis, Niki M Moutsopoulos, J Silvio Gutkind, Maria I Morasso
Science Translational Medicine. Vol. 10, Issue 451,: 2018. [ Journal Article ]

Job Vacancies

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Dr. Sarah Krantz
Postdoctoral Fellow (CRTA)
Sarah Krantz, Ph.D.
Holly Morrison
Postdoctoral Fellow (CRTA)
Holly Morrison, Ph.D.
Postdoctoral Fellow (Visiting)
Irving Garcia Jimenez, Ph.D.
Briana Branch
Pre-doctoral Fellow (Graduate Student)
Briana Branch, B.S.
Postbaccalaureate Fellow
Braden Bell, B.S.


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