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Ramiro Iglesias-Bartolome, Ph.D.

Ramiro Iglesias-Bartolome, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Our laboratory studies the signal and transcriptional networks regulating epithelial proliferation and differentiation, primarily using skin as a model system. The skin epidermis is functionally divided into compartments maintained by stem and transit-amplifying progenitor cells. Environmental assaults and genomic abnormalities can result in the imbalance of the homeostatic functions of epithelial cells, leading to uncontrolled cell proliferation or elimination of tissue-regenerative cells by death, differentiation, or senescence. Understanding the pathways regulating these cell fates can provide essential insights into cancer initiation and a host of pathologies involving progressive loss of tissue-specific regenerating cells.

Areas of Expertise

Skin epithelial stem cells, keratinocytes
G Protein Coupled Receptors (GPCRs), Hedgehog Signaling
Basal Cell Carcinoma

Publications

Selected Key Publications

YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity.

Yao Yuan, Jeannie Park, Amber Feng, Parirokh Awasthi, Zhiyong Wang, Qianming Chen, and Ramiro Iglesias-Bartolome
Nature Communications. 11(1): 1472, 2020.
Full-Text Article
[ Journal Article ]

The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis

Pedro MP, Lund K, Iglesias-Bartolome R.
Stem Cells. 38: 1520– 1531, 2020.
Full-Text Article

Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth

Hoy JJ, Salinas Parra N, Park J, Kuhn S, Iglesias-Bartolome R.
FASEB J.. 34(10): 13900-13917, 2020.
Full-Text Article
[ Journal Article ]

Activation of G-Protein Coupled Receptor–Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia

M. Pilar Pedro, Natalia Salinas Parra, J. Silvio Gutkind and Ramiro Iglesias-Bartolome
Journal of Investigative Dermatology. S0022-202X(19)33386-X: 2019.
Full-Text Article
[ Journal Article ]

Transcriptional signature primes human oral mucosa for rapid wound healing

Ramiro Iglesias-Bartolome, Akihiko Uchiyama, Alfredo A Molinolo, Loreto Abusleme, Stephen R Brooks, Juan Luis Callejas-Valera, Dean Edwards, Colleen Doci, Marie-Liesse Asselin-Labat, Mark W Onaitis, Niki M Moutsopoulos, J Silvio Gutkind, Maria I Morasso
Science Translational Medicine. Vol. 10, Issue 451,: 2018. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Signaling, skin, stem cells Ph.D. or equivalent, M.D. or equivalent Dr. Ramiro Iglesias-Bartolome ramiro.iglesias-bartolome@nih.gov

Team

Dr. Sarah Krantz
Postdoctoral Fellow (CRTA)
Sarah Krantz, Ph.D.
Dr. Pilar Pedro
Postdoctoral Fellow (Visiting)
Maria Del Pilar Pedro, Ph.D.
Irving
Postdoctoral Fellow (Visiting)
Irving Garcia Jimenez, Ph.D.
Briana Branch
Pre-doctoral Fellow (Graduate Student)
Briana Branch, B.S.
Katie Lund
Postbaccalaureate Fellow
Katherine M. Lund, B.S.

News

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