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Daniel W. McVicar, Ph.D.

Daniel W. McVicar, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. McVicar’s laboratory studies the regulation of innate immune cell metabolism and function in cancer. His research team uses a variety of cellular and molecular techniques to understand the biology and biochemistry of a variety of receptor systems including the triggering receptors expressed on myeloid cells (TREM) that regulate neutrophils, macrophages, monocytes, dendritic cells and platelets, and the killer Ig-like receptors (KIRs) that regulate natural killer (NK) cells. Components of signaling cascades identified by the laboratory are interrogated using murine models of infection and/or inflammation-associated cancers including hepatocellular carcinoma and colorectal cancer. Dr. McVicar leads the Cancer Innovation Laboratory (CIL) in his role as CCR Deputy Director.

Areas of Expertise

1) immunometabolism, 2) receptor biology, 3) intracellular signaling, 4) cancer inflammation, 5) myeloid cell regulation, 6) thrombosis, 7) metabolism

Publications

Selected Recent Publications

Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

Palmieri EM, McGinity C, Wink DA, McVicar DW.
Metabolites. 10(11): 429, 2020. [ Journal Article ]

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Walls JF, Subleski JJ, Palmieri EM, Gonzalez-Cotto M, Gardiner CM, McVicar DW, Finlay DK.
Elife. 9: e59166, 2020. [ Journal Article ]

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice CM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW.
Nat Commun. 11(1): 698, 2020. [ Journal Article ]

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW.
Nat Commun. 9(1): 5099, 2018. [ Journal Article ]

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

Weiss JM, Davies LC, Karwan M, Lleva L, Ozaki MK, Cheng RY, Ridnour LA, Annunziata CM, Wink DA, McVicar DW.
J. Clin. Invest. 128: 3794-3805, 2018. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (CRTA)
Ian Bettencourt, Ph.D.
Special Volunteer
Marieli Gonzalez-Cotto, Ph.D.
Research Fellow
Erika Palmieri, Ph.D.
Postdoctoral Fellow (CRTA)
Steven D. Schutt, Ph.D.
Research Biologist
Jeffrey Subleski
CRTA Fellow
Ian McClain-Caldwell, B.S.