Jonathan M. Weiss, Ph.D.

Jonathan M. Weiss, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 560; Room 31-45
  • Frederick, MD 21702-1201
  • (301) 846-5394
  • (301) 846-1673
Cancer Innovation Laboratory


Dr. Weiss is investigating the mechanisms whereby combinations of cytokines and other immune-modulating drugs, such as anti-CD40, result in the eradication of tumors. Principally, he is interested in understanding the mechanisms of leukocyte recruitment into the tumor microenvironment and the responses by these tumor-infiltrating leukocytes as they relate to tumor progression and/or metastases.

Areas of Expertise



Selected Publications

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

Weiss JM, Davies LC, Karwan M, Ileva L, Ozaki MK, Cheng RY, Ridnour LA, Annunziata CM, Wink DA, McVicar DW
J Clin Invest. 128(9): 3794-3805, 2018. [ Journal Article ]

Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy

Weiss JM, Subleski JJ, Back T, Chen X, Watkins SK, Yagita H, Sayers TJ, Murphy WJ, Wiltrout RH
J Immunol. 192: 5821-9, 2014. [ Journal Article ]

CD40 expression in renal cell carcinoma is associated with tumor apoptosis, CD8(+) T cell frequency and patient survival

Weiss JM, Gregory Alvord W, Quiñones OA, Stauffer JK, Wiltrout RH
Hum Immunol. 75: 614-20, 2014. [ Journal Article ]

Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy

Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH
J Exp Med. 207: 2455-67, 2010. [ Journal Article ]

Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment

Weiss JM, Back TC, Scarzello AJ, Subleski JJ, Hall VL, Stauffer JK, Chen X, Micic D, Alderson K, Murphy WJ, Wiltrout RH
Proc Natl Acad Sci U S A. 106: 19455-60, 2009. [ Journal Article ]