Nitin Roper, M.D., M.Sc.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 5056B
- Bethesda, MD 20892
Dr. Roper is a physician-scientist with a research focus on neuroendocrine tumors, particularly small cell lung cancer and adrenocortical carcinoma. Specifically, Dr. Roper is engaged in translational research aimed at understanding the relationship between Notch signaling and immunologic, epigenetic and molecular aspects of neuroendocrine tumors with the goal of translating experimental data to the clinic. Dr. Roper will be a Lasker Clinical Research Scholar/Tenure-Track Investigator starting in July 2023.
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My overall research goal is to decipher the mechanisms that augment treatment response in neuroendocrine tumors. In particular, I am interested in: 1) deciphering the biologic mechanisms of neuroendocrine tumors that may, in turn, predict response or lack of response to immune checkpoint inhibition; 2) elucidating the epigenetic mechanisms which drive neuroendocrine tumors; and 3) establishing pre-clinical, organoid models of neuroendocrine tumors. These studies will inform rational combinations to augment both epigenetic and immunotherapy approaches within neuroendocrine tumors.
Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer
Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors
Nitin Roper, M.D., M.Sc.
After completing his undergraduate work at Brown University, Dr. Roper received his M.D. at the University of Connecticut School of Medicine. He completed an internship and residency in internal medicine at Mount Sinai Hospital in New York City. He subsequently obtained a Master’s in Clinical Research Methods from Columbia University, Mailman School of Public Health and was an Instructor in Medicine at Weill Cornell Medical College. He completed medical oncology training through the NHLBI-NCI Hematology Oncology Fellowship program and is board certified in Medical Oncology. Dr. Roper joined the Developmental Therapeutics Branch as a Physician Scientist Early Investigator in the fall of 2019.
|Position||Degree Required||Contact Name||Contact Email|
|Postdoctoral Fellows - Immuno-oncology, neuroendocrine cancers, small cell lung cancer||Ph.D. or equivalent||Nitin Roperemail@example.com|
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