Nitin Roper, M.D., M.Sc.

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch


Dr. Roper is a physician-scientist with a research focus on neuroendocrine tumors, particularly small cell lung cancer and adrenocortical carcinoma. Specifically, Dr. Roper is engaged in translational research aimed at understanding the relationship between Notch signaling and immunologic, epigenetic and molecular aspects of neuroendocrine tumors with the goal of translating experimental data to the clinic. 

Areas of Expertise

Notch Signaling
Small Cell Lung Cancer
Tumor Heterogeneity

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Selected Recent Publications

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan & Anish Thomas
Nature Communications. 2021.
Full-Text Article
[ Journal Article ]

Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer

Nitin Roper, Anna-Leigh Brown, Jun S Wei, Svetlana Pack, Christopher Trindade, Chul Kim, Olivia Restifo, Shaojian Gao, Sivasish Sindiri, Farid Mehrabadi, Rajaa El Meskini, Zoe Weaver Ohler, Tapan K Maity, Abhilash Venugopalan, Constance M Cultraro, Elizabeth Akoth, Emerson Padiernos, Haobin Chen, Aparna Kesarwala, DeeDee K Smart, Naris Nilubol, Arun Rajan, Zofia Piotrowska, Liqiang Xi, Mark Raffeld, Anna R Panchenko, Cenk Sahinalp, Stephen Hewitt, Chuong D Hoang, Javed Khan, Udayan Guha
Cell Reports Medicine. 1: 2020.
Full-Text Article
[ Journal Article ]

APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors

Nitin Roper, Shaojian Gao, Tapan K Maity, A Rouf Banday, Xu Zhang, Abhilash Venugopalan, Constance M Cultraro, Rajesh Patidar, Sivasish Sindiri, Anna-Leigh Brown, Alexander Goncearenco, Anna R Panchenko, Romi Biswas, Anish Thomas, Arun Rajan, Corey A Carter, David E Kleiner, Stephen M Hewitt, Javed Khan, Ludmila Prokunina-Olsson, Udayan Guha
Cell Reports. 2019.
Full-Text Article
[ Journal Article ]

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Research Fellow
Yoo Sun Kim, Ph.D.
Postdoctoral Fellow (Visiting)
Afeez Ishola, Ph.D.
Postdoctoral Fellow (Visiting)
Nai-Yun Sun, Ph.D.
Postbaccalaureate CRTA
Dhearaj Chennupati
Postbaccalaureate CRTA
Sarah Loew


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