Dr. Natalie Porat-Shliom

Natalie Porat-Shliom, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Thoracic and GI Malignancies Branch


Dr. Porat-Shliom is a cell biologist with expertise in light microscopy techniques, particularly, intravital microscopy. Her lab uses a combination of molecular, biochemical and imaging approaches to investigate the principles underlying mitochondrial structure and function and the changes under pathological conditions such as Non-Alcoholic Fatty Liver Disease.

Areas of Expertise

Mitochondria Biology
Intravital Microscopy
Liver Physiology

CCR Liver Cancer Program

A multidisciplinary research network dedicated to improving early detection, diagnosis, prognosis and treatment of liver cancer.


A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

Sun Woo Sophie Kang, Rory P. Cunningham, Colin B. Miller, Lauryn A. Brown, Constance M. Cultraro, Adam Harned, Kedar Narayan, Jonathan Hernandez, Lisa M. Jenkins, Alexei Lobanov, Maggie Cam & Natalie Porat-Shliom
Nature Communications. 2024.
Full-Text Article
[ Journal Article ]

Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation

Porat-Shliom N
Curr Opin Cell Biol. 2024. [ Journal Article ]

LKB1 acts as a critical brake for the glucagon-mediated fasting response

Suehelay Acevedo-Acevedo,Megan L. Stefkovich,Sun Woo Sophie Kang,Rory P. Cunningham,Constance M. Cultraro,Natalie Porat-Shliom
Hepatology Communications. 2022.
Full-Text Article
[ Journal Article ]

Liver Zonation - Revisiting Old Questions With New Technologies

Rory P Cunningham and Natalie Porat-Shliom
Front Physiol.. 2021.
Full-Text Article
[ Journal Article ]

Intravital Microscopy for the Study of Hepatic Glucose Uptake

Megan L Stefkovich, Sun Woo Sophie Kang, Natalie Porat-Shliom
Curr Protoc. 1(5): e139, 2020.
Full-Text Article
[ Journal Article ]

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Lauryn Brown
Post Baccalaureate Fellow (IRTA/CRTA)
Lauryn Brown, B.S.
Mercedes Cornelius
Pre-doctoral IRTA (Graduate student)
Mercedes Cornelius, B.S.
Senior Research Assistant
Constance M Cultraro, Ph.D.
Colin Miller
Post Baccalaureate Fellow (IRTA/CRTA)
Colin Miller, B.S.


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