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Headshot of Chunzhang Yang

Chunzhang Yang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch

RESEARCH SUMMARY

Dr. Chunzhang Yang studies the genetic and molecular basis of brain tumors, and leads the Molecular and Cell Biology Research Program at the Neuro-Oncology Branch (NOB). The goal of his research is to understand the vulnerabilities of brain tumors and identify biological signatures—which can be used to generate experimental therapeutics that improve the current standard of care for patients. 

His lab utilizes traditional molecular biology techniques and preclinical models to determine the relevance of DNA repair pathway blockades. He also studies other key pathways that could be inhibited in brain tumors to elicit more cell death, improve disease outcomes, and diminish therapeutic resistance. The primary approaches that Dr. Yang’s team uses include functional analysis of cancer biology, identification of actionable therapeutic targets, and development of experimental therapeutics for next step clinical application. 

Explore the NOB's Research Programs >

Areas of Expertise

Publications

Selected Key Publications

Protein kinase B (PKB/AKT) protects IDH-mutated glioma from ferroptosis via Nrf2

Liu Y, Chou FJ, Lang F, Zhang M, Song H, Zhang W, Davis DL, Briceno NJ, Zhang Y, Cimino PJ, Zaghloul KA, Gilbert MR, Armstrong TS, Yang C.
Clin. Cancer Res.. In Press: 2023.
Full-Text Article
[ Journal Article ]

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

Yu D, Liu Y, Zhou Y, Ruiz-Rodado V, Larion M, Xu G, Yang C.
Proc Natl Acad Sci U S A. . 117(18): 9964-9972, 2020.
Full-Text Article
[ Journal Article ]

Targeting IDH1-Mutated Malignancies with NRF2 Blockade

Liu Y, Lu Y, Celiku O, Li A, Wu Q, Zhou Y, Yang C.
J. Natl. Cancer Inst. 111(10): 1033-1041, 2019.
Full-Text Article
[ Journal Article ]

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma

Pang Y, Lu Y, Caisova V, Liu Y, Bullova P, Huynh TT, Zhou Y, Yu D, Frysak Z, Hartmann I, Taïeb D, Pacak K, Yang C.
Clin. Cancer Res. 24(14): 3423-3432, 2018.
Full-Text Article
[ Journal Article ]

Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia

Zhuang Z, *Yang C, Lorenzo F, Merino M, Fojo T, Kebebew E, Popovic V, Stratakis CA, Prchal JT, Pacak K (*Co-first author)
N Engl J Med. 367(10): 922-930, 2012.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Postdoctoral Fellow (CRTA)
Fu-Ju Chou, Ph.D.
Postdoctoral Fellow (Visiting)
Fengchao Lang, Ph.D.
Research Fellow
Yang Liu, Ph.D.
Postdoctoral Fellow (Visiting)
Yang Zhang, Ph.D.

News

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Glioma cell in motion

Exploiting Brain Cancer Cells’ Vulnerabilities to Combat Treatment Resistance

As head of the Molecular and Cell Biology Program, Dr. Chunzhang Yang investigates whether genetic mutations in cancer cells could serve as therapeutic targets. Read more 

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Student working at a computer

2021 Summer Internship Program

The NOB welcomed six summer interns for the summer 2021 cohort who were able to observe and engage with clinical and laboratory professionals that lead clinical, translational, and basic research. Read more >

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Scientist in lab working at computer

Neuro-Oncology Branch 2020 Year in Review

January 22, 2021

Together, our clinical team, research laboratories, and staff have made meaningful advancements to improve outcomes for patients and their families impacted by brain and spine tumors. Read more >

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Dr. Chunzhang Yang and Dr. Yang Liu

Celebrating National Mentoring Month

January 31, 2020

We celebrate our impactful mentors in the Neuro-Oncology Branch for National Mentoring Month. Our postdoctoral fellows share their love for science and how their mentors have made their experience at NIH more rewarding. Read more >

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Nanoparticles in brain metastases

New Strategy for Treating Brain Tumors with Mutations in Metabolic Enzymes 

February 20, 2019

Dr. Chunzhang Yang and his team uncovered the molecular effects of IDH mutations in gliomas, including stress, reactive oxygen species and changes in a protein named NRF2. Read more >

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PARP enzymes help repair damaged DNA. PARP inhibitors block this repair mechanism, causing some cancer cells to die.

PARP Inhibitors May be Effective in Brain, Other Cancers with IDH Mutations 

April 24, 2017

Two separate studies revealed insights into the function of genetic mutations commonly found in a form of brain cancer—and, in the process, identified a potential new treatment strategy. Read more >