Lino  Tessarollo, Ph.D.

Lino Tessarollo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Tessarollo’s research is focused on signaling of neurotrophins and their Trk receptors in development and disease. Some of the main contributions of his laboratory include the findings that neurotrophins are critical for energy homeostasis of the organism, they have functions outside the nervous system and truncated Trk receptors are important transducers of neurotrophin signaling in vivo. Dr. Tessarollo is Director of the Mouse Cancer Genetics Program and the Gene Targeting Facility.

Areas of Expertise

Genome Editing
Neurotrophin Signaling


Selected Recent Publications

Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous

Sudhirkumar Yanpallewar 1, Gianluca Fulgenzi 1, Francesco Tomassoni-Ardori 1, Colleen Barrick 1, Lino Tessarollo 2
Exp Neurol. 2021 Mar;337:113576.doi: 10.1016: 2021.
Full-Text Article
[ Journal Article ]

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

Fulgenzi G, Hong Z, Tomassoni-Ardori F, Barella LF, Becker J, Barrick C, Swing D, Yanpallewar S, Croix BS, Wess J, Gavrilova O, Tessarollo L.
Nat Commun. 11(1): 1950, 2020. [ Journal Article ]

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Tomassoni-Ardori F, Fulgenzi G, Becker J, Barrick C, Palko ME, Kuhn S, Koparde V, Cam M, Yanpallewar S, Oberdoerffer S, Tessarollo L.
Elife. 8: e49673, 2019. [ Journal Article ]

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

Gianluca Fulgenzi, Francesco Tomassoni-Ardori, Lucia Babini, Jodi Becker, Colleen Barrick, Sandrine Puverel, Lino Tessarollo
J. Cell Biology. 2015 Sep 14;210(6):1003-12. : 2015. [ Journal Article ]

TrkA in vivo function is negatively regulated by ubiquitination

Erkan Kiris 1 , Ting Wang, Sudhirkumar Yanpallewar, Susan G Dorsey, Jodi Becker, Sina Bavari, Mary Ellen Palko, Vincenzo Coppola, Lino Tessarollo
J. Neuroscience. 2014 Mar 12;34(11):4090-8. : 2014. [ Journal Article ]

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Animal Technician (Contr.)
Colleen Barrick
Staff Scientist
Kuo-Sheng (Frank) Hsu, Ph.D.
Mary Ellen Palko
Postdoctoral Fellow (Visiting)
Nicola Boccella, Ph.D.


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