The past Grand Rounds lectures can be found here:
June 7 - Targeting Myelodysplasia – RNA Biology and In Vivo Modeling of Myelodysplastic Syndromes
Stephanie Halene, M.D.
Arthur H and Isabel Bunker Professor of Medicine (Hematology) and Professor of Pathology
Chief, Section of Hematology
Director, DeLuca Center for Innovation in Hematology Research, Yale Cancer Center
Assistant Medical Director CRSL, Yale Cancer Center
Chief, Translational Hematology, Yale School of Medicine
May 17 - New Frontiers of Cancer Cell and Gene Therapy: Is the Future Now?
Rayne H. Rouce, M.D.
Associate Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
Associate Director, Community Engagement, Office of Diversity, Baylor College of Medicine
May 10 - Lentiviral Gene Therapy for Blood Disorders: Wiskott-Aldrich Syndrome
Sung-Yun Pai, M.D.
Chief and Senior Investigator, Immune Deficiency Cellular Therapy Program, CCR, NCI
April 26 - Learning the Molecular Logic of Cancer
Eliezer Van Allen, M.D.
Associate Professor, Medicine, Harvard Medical School
Associate Professor, Medical Oncology, Dana-Farber Cancer Institute
April 19 - Glypicans as Cancer Targets for CAR-T Immunotherapy
Mitchell Ho, Ph.D.
Deputy Chief and Senior Investigator, Laboratory of Molecular Biology, CCR, NCI
Director, NCI CCR Antibody Engineering Program
March 22 - Biomaterials to Promote T Cell Immunity
David J. Mooney, Ph.D.
Founding Core Faculty & Lead, Immuno-Materials, Wyss Institute at Harvard University
Robert P. Pinkas Family Professor of Bioengineering, Harvard John A. Paulson School of Engineering and Applied Sciences
March 15 - Special CCR Nursing Grand Rounds: Challenges to Implementing Recommended Chemotherapy-Induced Periphera Neuropathy Assessment and Management Strategies into Clinical Practice
Robert Knoerl, Ph.D., RN
Assistant Professor, Department of Health Behavior and Biological Sciences at the University of Michigan School of Nursing
March 1 - Hidden in Plain Sight: Kaposi Sarcoma and other KSHV-Associated Disorders
Ramya Ramaswami, M.B.B.S., M.P.H.
Lasker Clinical Research Scholar, HIV and AIDS Malignancy Branch, CCR, NCI
February 9 - Promising Practices for Advancing Gender Equity in Science, Engineering, and Medicine
Ashley Bear, Ph.D.
Director, Committee on Women in Science, Engineering, and Medicine
National Academies of Sciences
February 2 - Targeting Multiple Survival Pathways in Aggressive B-cell Lymphomas
Wyndham Wilson, M.D., Ph.D.
Senior Investigator, Lymphoid Malignancies Branch, CCR, NCI
January 19 - Assembling Digital Tumor Cells for Precision Oncology
Trey Ideker, Ph.D., Professor, Department of Medicine
Adjunct Professor, Departments of Bioengineering and Computer Science
Co-Director, Bioinformatics, and Systems Biology Ph.D. Program, University of California San Diego
December 8 - Histone Acetyltransferase Inhibitors Arrive
Jordan L. Meier, Ph.D., Senior Investigator, Chemical Biology Laboratory, CCR, NCI
Head, Epigenetics and Metabolism Section
December 1 - Cancer Genetics and Prevention: Nursing Practice and Science Implications
Meghan L. Underhill-Blazey, Ph.D., APRN, AOCNS, Assistant Professor
Nurse Practitioner, Wilmot Cancer Institute Hereditary Cancer Program
School of Nursing, University of Rochester
October 27 - Melanoma Control by its Cross Talk with the Microenvironment
Ze'ev Ronai, Ph.D., Director, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
October 20 - A Garden of Forking Paths: Branching, Switching, and Reversing in Homologous Recombination
Michael Lichten, Ph.D., NIH Scientist Emeritus, Laboratory of Biochemistry and Molecular Biology, CCR, NCI
September 29 - Big Data Approaches to Study Intercellular Signaling During Tumor Immune Evasion
Peng Jiang, Ph.D., Stadtman Investigator, Cancer Data Science Laboratory, CCR, NCI
September 22 - Immunotherapy of Liver Cancer: From Bench to Bedside and Back to the Bench
Tim F. Greten, M.D., Deputy Chief, Thoracic and GI Malignancies Branch
Co-Director, NCI CCR Liver Cancer Program, CCR, NCI
June 23 - Immune Checkpoint Inhibitor Therapy and the Gut Microbiome: A Complex Relationship with Significant Implications in Cancer Treatment
Amiran K. Dzutsev, M.D., Ph.D., Staff Scientist, Cancer and Inflammation Program, CCR, NCI
June 9 - Organoids and Cell Polarity Proteins in Translational and Mechanistic Cancer Research
Senthil K. Muthuswamy, Ph.D., Chief, Laboratory of Cancer Biology and Genetics, CCR, NCI
May 19 - Fueling Anti-Tumor T Lymphocytes: CARs and More
Naomi Taylor, M.D., Ph.D., Senior Investigator, Pediatric Oncology Branch, CCR, NCI
May 5 - CD19 CAR T Cells and the “Living Drug” Concept
Michel Sadelain, M.D., Ph.D., Stephen and Barbara Friedman Chair
Director, Center for Cell Engineering, Memorial Sloan Kettering Cancer Center
March 31 - Studying Precision Oncology Past by Mining a Clinical Trials Database and Identifying Future Opportunities from Single-Cell Analysis
Alejandro A. Schäffer, Ph.D., Staff Scientist, Cancer Data Science Laboratory, CCR, NCI
March 24 - Insights Gained from Investigating Genomic Junk
Matthew L. Freedman, M.D., Professor, Medicine, Harvard Medical School
Associate Physician, Medical Oncology Service, Dana-Farber Cancer Institute
March 3 - Interprofessional Communication Curriculum (ICC)
Betty Ferrell, R.N., Ph.D., M.A., C.H.P.N., F.A.A.N., F.P.C.N., Director and Professor Division of Nursing Research and Education, Department of Population Sciences, City of Hope
February 24 - Targeting Myeloid Cells in Cancer
Miriam Merad, M.D., Ph.D., Director, Precision Immunology Institute
Professor, Oncological Sciences
Professor, Medicine, Hematology and Medical Oncology
Professor, Dermatology
Icahn School of Medicine at Mount Sinai
February 10 - Strategies to Accelerate Patient and Workforce Diversity, Equity, and Inclusion
Julie Silver, M.D., Associate Professor & Associate Chair, Department of Physical Medicine & Rehabilitation, Harvard Medical School
February 3 - Personalized Cellular Therapy for Cancer
Antoni Ribas, M.D., Ph.D., Professor, Medicine, Surgery, Molecular and Medical Pharmacology
Director, Parker Institute for Cancer Immunotherapy Center at UCLA
Director, UCLA Jonsson Comprehensive Cancer Center Tumor Immunology Program
January 20 - Exploring the Connection Between Telomeres, Cancer, and Development
Eros Lazzerini Denchi, Ph.D., Senior Investigator, Laboratory of Genome Integrity, CCR, NCI
December 9 - The Epigenetic Dynamics of X-Chromosome Inactivation in Development and Disease
Edith Heard, FRS, Director General, European Molecular Biology Laboratory
November 18 - Combination Immunotherapy in HPV Associated Malignancies and Other Solid Tumors
Julius Strauss, M.D.
November 4 - How Can We Accelerate the Development of Combination Regimens?
Keith T. Flaherty, M.D., Director of Clinical Research, Mass General Cancer Center, Massachusetts General Hospital
October 28 - Exosomes and Other Extracellular Particles in Liquid Biopsies: New keys to Decoding ‘The Commotion in the Blood
Jennifer Clare Jones, M.D., Ph.D., Laboratory of Pathology, CCR, NCI
NIH Distinguished Scholar
Head, Translational Nanobiology Section
September 9 - Mechanisms of Resistance to Anticancer Therapies
Oskar Fernandez-Capetillo, Ph.D., Director of the Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
July 29 - Towards Rational Combination Therapies: Understanding Tumor Evolution During Therapy Response and Resistance
Anna Obenauf, Ph.D., Group Leader, Research Institute of Molecular Pathology, Vienna BioCenter
June 10 - Genomics and Beyond: How We Need to Improve on Precision Medicine
Emile E. Voest, M.D., Ph.D., Medical Director, Board of Directors, Netherlands Cancer Institute
May 20 - Chromosome End Protection
Simon Boulton Ph.D., FMedSci, Director, CRUK, RadNet - City of London
Senior Group Leader, The Francis Crick Institute
May 13 - Immunomodulation To Treat HIV Associated Lymphomas
Kathryn A. Lurain, M.D., M.P.H., Assistant Research Physician, HIV and AIDS Malignancy Branch, CCR, NCI
April 29 - Shark-Derived Nanobodies as Future Diagnostic and Therapeutic Agents
Helen Dooley Ph.D., Assistant Professor, Dept. Microbiology & Immunology, University of Maryland School of Medicine
April 22 - Advancing Prostate Cancer Diagnostics: Guiding Clinical Management via Imaging and Artificial Intelligence
Ismail Baris Turkbey, M.D., Senior Clinician, Molecular Imaging Branch, CCR, NCI
March 11 - Imaging tumor initiation and progression in live animals at cellular and sub-cellular resolution
Roberto Weigert, Ph.D., Senior Investigator, Laboratory of Cellular & Molecular Biology, CCR, NCI
February 25 - (Childhood) Brain Tumor Diagnostics in 2022
Prof. Dr. med. Stefan M. Pfister, Director, Preclinical Pediatric Oncology, Hopp Children's Cancer Center Heidelberg, German Cancer Research Center
February 11 - Persisted: Breaking Barriers to the Advancement of Women in Science
Cassidy R. Sugimoto, Ph.D., Tom and Marie Patton School Chair
Professor, Georgia Institute of Technology
February 4 - Precisely Practicing Medicine from 700 Trillion Points of Data
Atul Butte, M.D., Ph.D., Professor, Pediatrics, Priscilla Chan and Mark Zuckerberg Distinguished Professor, School of Medicine
January 28 - Cellular Therapy in the Evolving Therapeutic Landscape of Metastatic Melanoma
Stephanie L. Goff, M.D., Associate Research Physician, Surgery Branch, CCR, NCI
January 21 - Patient-reported Outcomes for Symptom Monitoring in Oncology
Ethan Basch, M.D., M.Sc., Richard M. Goldberg Distinguished Professor of Medical Oncology
Chief, Division of Oncology
Physician-in-Chief, NC Cancer Hospital
University of North Carolina
December 17 - Advances in the Understanding of the Pathogenesis and Management of Neuroendocrine Tumors
Steven Libutti, M.D., FACS, Director, Rutgers Cancer Institute of New Jersey
Rutgers Cancer Institute of New Jersey
December 10 - The Canary Prostate Pathology Project: Creating Optimal Definitions for "Adverse Pathology" and "Significant Prostate Cancer" with Improved Utility in Clinical Management and Research
Jesse McKenney, M.D., Vice Chair for Faculty Development, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic
December 3 - Cancer and the Epigenetic Clock
Bradley E. Bernstein, M.D., Ph.D., Professor, Massachusetts General Hospital
Professor, Harvard Medical School
Director, Broad Epigenomics Program and Broad Gene Regulation Observatory
November 19 - Harnessing Transposon Mutagenesis to Study Tumor Evolution and Tumor
Nancy Jenkins, Ph.D. and Neal Copeland, Ph.D., Researchers - MD Anderson Cancer Center
November 5 - Eat to Live: A Role for Diet in Cancer Therapy
Karen Vousden CBE, FRS, FRSE, Chief Scientist, Cancer Research UK
Senior Group Leader, The Francis Crick Institute
October 22 - PD-1 Pathway Blockade: A Common Denominator for Cancer Therapy
Suzanne Topalian, M.D., Associate Director, Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine
October 15 - Necrophagia, DaNGeRous Indigestion and Immunity to Cancer
Caetano Reis e Sousa, D.Phil FRS FMedSci, Assistant Research Director and Senior Group Leader
Head, Immunobiology Laboratory
The Francis Crick Institute
October 1 - Microenvironment regulation of metastasis
Kandice Tanner, Ph.D., Senior Investigator, Laboratory of Cell Biology, CCR, NCI
Head, Tissue Morphodynamics Section
September 24 - Romidepsin, an Epigenetic Agent from Bench to Bedside and Back to Bench
Susan E. Bates, M.D., Columbia University, Herbert Irving Comprehensive Cancer Center
Director, Translational Cancer Medicine
August 6 - Understanding and Targeting Small Cell Lung Cancer
Triparna Sen, Ph.D., Assistant Attending, Department of Medicine, Memorial Sloan Kettering Cancer Center
June 11 - Lung Cancer Then and Now
David P. Carbone, M.D., Ph.D., Barbara J. Bonner Chair in Lung Cancer Research
Past President, International Association for the Study of Lung Cancer
Professor of Medicine
Director, James Thoracic Center
The Ohio State University Medical Center
June 4 - The makings of B cell lymphoma
Riccardo Dalla-Favera, M.D., Department of Genetics and Development, Columbia University
May 21 - Next Generation Platforms to Enhance CAR T Cell Therapeutics
Crystal Mackall, M.D., Professor of Pediatrics and Internal Medicine, Stanford University
May 7 - Revealing ciliogenesis mechanisms in normal and diseased states
Christopher J. Westlake, Ph.D., Senior Investigator, Laboratory of Cell and Developmental Signaling Head, Membrane Trafficking and Signaling Section, CCR, NCI
April 30 - Genome Editing with Compact Cas9s, Anti-CRISPRs, and Modified Guides and Donors
Erik Sontheimer, Ph.D., Pillar Chair in Biomedical Research, University of Massachusetts
April 23 - Human steroid metabolism phenotypes in prostate cancer and beyond
Nima Sharifi, M.D., Director, Center for GU Malignancies Research, Cleveland Clinic Lerner Research Institute
March 26 - Rare CNS tumors in Adults: opportunities to expedite progress
Marta Penas-Prado, M.D., Associate Research Physician, Neuro-Oncology Branch, CCR, NCI
February 26 - Defining Liver Cancer Heterogeneity – New Challenges and Opportunities
Xin Wei Wang, Ph.D., Deputy Chief, Laboratory of Human Carcinogenesis, CCR, NCI
February 12 - Neuron-glial Interactions in Health and Disease: from Cognition to Cancer
Michelle Monje Deisseroth, M.D., Ph.D., Associate Professor of Neurology, Stanford University
February 5 - Germline predisposition to hematopoietic malignancies
Lucy Godley, M.D, Ph.D., Professor of Medicine, University of Chicago Medicine
January 29 - Taking a ride on the nucleosome: of histone chaperones and chromatin remodelers
Karolin Luger, Ph.D., Professor • Jennie Smoly Caruthers Endowed Chair of Biochemistry
University of Colorado, Boulder
December 11 - Thymus-specific proteasome for CD8 T cell selection (Talk starts at 4:29)
Yousuke Takahama, Ph.D., Senior Investigator, Experimental Immunology Branch, CCR, NCI
November 20 - Metabolic Barriers to Effective Cancer Immunotherapy
Greg Delgoffe, Ph.D., Assistant Professor, Department of Immunology, University of Pittsburgh
November 6 - Targeting hormone-driven DNA repair in prostate cancer: mechanisms and clinical implications
Karen E. Knudsen, M.B.A., Ph.D., Executive Vice President, Oncology Services, Jefferson Health
Enterprise Director- NCI-Designated Sidney Kimmel Cancer Center
Thomas Jefferson University
October 23 - The Hsp70 Molecular Chaperone Machine and Its Selectively Promiscuous Interaction with Substrates
Lila M. Gierasch, Ph.D., Distinguished Professor, University of Massachusetts Amherst
October 16 - Precision Medicine Approaches in Lymphoma
Mark Roschewski, M.D., Senior Clinician, Lymphoid Malignancies Branch
Clinical Director, Lymphoid Malignancies Branch, CCR, NCI
September 11 - Somatic mutations in normal tissues
Peter Campbell, Ph.D., Head of Cancer, Ageing and Somatic Mutation & CASM Team
Wellcome Genome Campus
August 28 - Mapping Cancer Genetics at Single Cell Resolution
Luke Gilbert, Ph.D., Assistant Professor, Helen Diller Family Comprehensive Cancer Center
June 26 - A Comparative Approach to Cancer Research: Man’s Best Friend is More Than Just a Companion
Amy K. LeBlanc, D.V.M., Senior Scientist, Molecular Imaging Program, Director, Comparative Oncology Program, CCR, NCI
June 5 - Multi-Omics Applications in Human Liver Cancer
Anuradha S. Budhu, Ph.D., Senior Associate Scientist, Laboratory of Human Carcinogenesis, Program Manager, Liver Cancer Program, CCR, NCI
May 22 - Tumor Plasticity and Resistance to Immunotherapy
Claudia M. Palena, Ph.D., Senior Investigator, Head, Immunoregulation Section, Laboratory of Tumor Immunology and Biology, CCR, NCI
May 8 - Targeting Functionally Diverse Nucleic Acids With Druglike Small Molecules
John 'Jay' Schneekloth Jr., Ph.D., Senior Investigator, Head, Chemical Genetics Section
Chemical Biology Laboratory, CCR, NCI
April 24 - Modeling the Genesis, Progression and Treatment of Human Melanoma in the Mouse
Glenn Merlino, Ph.D., Senior Investigator, Laboratory of Cancer Biology and Genetics
Scientific Director for Basic Science, CCR, NCI
March 6 - The Case for BK Polyomavirus as a Cause of Bladder Cancer
Christopher Buck, Ph.D., Senior Investigator, Head, Tumor Virus Molecular Biology Section, Laboratory of Cellular Oncology, CCR, NCI
February 28 - Cellular Therapy Targeting Malignant Brain Tumors
Duane A. Mitchell, M.D., Ph.D., Phyllis Kottler Friedman Professor
Co-Director, Preston A. Wells, Jr. Center for Brain Tumor Therapy
University of Florida Academic Health Center
February 21 - The Proteasome: Substrate Receptors and Beyond
Kylie J. Walters, Ph.D., Senior Investigator and Acting Chief, Structural Biophysics Laboratory, CCR, NCI
February 7 - Hereditary Cancer Mutation and Drug Development
Pamela Munster, M.D., Professor, Department of Medicine (Hematology/Oncology)
Director, Early Phase Clinical Trials Unit
UCSF Helen Diller Family Comprehensive Cancer Center
January 24 - The Early Metastatic Microenvironment and Approaches to Rebalance the Dysregulated Niche
Rosandra N. Kaplan, M.D., Investigator, Head, Tumor Microenvironment Section, Pediatric Oncology Branch, CCR, NCI
January 10 - Poly-Aneuploid Cancer Cells: Actuators of Cancer Resistance
Kenneth J. Pienta, M.D., Professor of Pharmacology and Molecular Sciences, Johns Hopkins Hospital
December 13 - Mining the Unexplored Cancer Kinome for Novel Therapeutic Targets in Squamous Cell Carcinomas
John Brognard, Ph.D., Investigator, Head, Signaling Networks in Cancer Section
Laboratory of Cell and Developmental Signaling, CCR, NCI
December 6 - Harnessing Genetic Interactions to Advance Precision Targeted and Immune Therapy of Cancer
Eytan Ruppin, M.D., Ph.D., Senior Investigator and Chief, Cancer Data Science Laboratory, CCR, NCI
November 1 - Phantoms in the Transcriptome: How Nucleic Acid Modifications Shape Gene Expression in Development and Disease
Shalini Oberdoerffer, Ph.D., Senior Investigator, Head, RNA Processing in Cellular Development Section, Laboratory of Receptor Biology and Gene Expression, CCR, NCI
October 4 - Splicing Factor Mutations in Myeloid Malignancies
Daniel Larson, Ph.D., Senior Investigator, Head, Systems Biology of Gene Expression, Laboratory of Receptor Biology and Gene Expression, CCR, NCI