Brad  St. Croix, Ph.D.

Brad St. Croix, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. St. Croix pioneered the development of methods to uncover molecules expressed on the tumor vasculature. He is now exploiting this new knowledge to better understand the process of new blood vessel formation, i.e. angiogenesis, and target the neovasculature that feeds tumors in order to develop more effective therapies for cancer. His recent studies describe the development of new therapeutic monoclonal antibodies that are non-toxic and have potential to aid in the management of cancer and other vascular diseases. The Tumor Angiogenesis Unit develops new approaches to detect and treat primary and metastatic disease through targeting of the tumor microenvironment.

Areas of Expertise

Tumor Angiogenesis
Endothelial Cell Biology
Vascular Biology
Tumor Endothelial Marker 8 (TEM8)/Anthrax Toxin Receptor 1 (ANTXR1)


Selected Recent Publications

Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability

Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Veera V Shivaji R Edupuganti, Kuo-Sheng Hsu, Christopher Dower, Guojun Yu, Daeho So, Pradip Bajgain, Zhongyu Zhu, Dimiter S Dimitrov, Nimit L Patel, Christina M Robinson, Simone Difilippantonio, Marzena Dyba, Amanda Corbel, Falguni Basuli, Rolf E Swenson, Joseph D Kalen, Sreedhar Reddy Suthe, Myer Hussain, James S Italia, Colby A Souders, Ling Gao, Martin J Schnermann, Brad St Croix
Cell Rep. 42: Online ahead of print, 2023.
Full-Text Article
[ Journal Article ]

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo & Brad St. Croix
Nat Communications. 2022 Nov 18;13(1):7078. doi: 10.1038/s41467-022-34643-5.: 2022.
Full-Text Article
[ Journal Article ]

Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.

Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B.
J Clin Invest.. Jun 4. pii: 120481. doi: 10.1172/JCI120481. [Epub ahead of print]: 1-17, 2018.
Full-Text Article
[ Journal Article ]

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B
Cancer Cell. 31(4):501-515.e8. : 2017.
Full-Text Article
[ Journal Article ]

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

Posokhova E, Shukla A, Seaman S, Volate S, Hilton MB, Wu B, Morris H, Swing DA, Zhou M, Zudaire E, Rubin JS, St Croix B
Cell Rep. 10(2): 123-130, 2015.
Full-Text Article
[ Journal Article ]

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Postdoctoral Fellow (Visiting)
Pradip Bajgain, Ph.D.
Yang Feng, Ph.D.
Senior Research Assistant
Steven Seaman, MSc
Postdoctoral Fellow (Visiting)
Daeho So, Ph.D.
Postdoctoral Fellow (Visiting)
Liping Yang, Ph.D.
Postdoctoral Fellow (Visiting)
Jaewon Lee, Ph.D.
Staff Scientist
GuoJun Yu, Ph.D.


Congratulations to Chris for his 2018 J Clin Invest: paper!

McCann JV, Null JL, & Dudley AC, J Clin InvestDeadly DAaRTS destroy cancer cells via a tumor microenvironment-mediated trigger

CCR News headlines:  Antibody-linked drug shrinks various types of tumors in preclinical study

Congratulations to Steve for his 2017 Cancer Cell paper!

Khan KA & Kerbel RS, Cancer Cell: A CD276 Antibody Guided Missile with One Warhead and Two Targets: The Tumor and Its Vasculature

CCR News headlines: Antibody-linked drug destroys tumor cells and tumor blood vessels in many types of cancer

Cancer Discovery: An Anti-CD276 Antibody–Drug Conjugate Kills Tumor Cells and Vasculature

The Dossier newsletter:  September 2017, Issue 29: The Authors Corner. 

Congratulations to Lihong for her 2014 Science Translational Medicine paper!

Cancer Discovery: Dual COX2–VEGF Blockade Suppresses Tumor Angiogenesis and Metastasis

CCR News:  COX-2 – A Novel Target for Reducing Tumor Angiogenesis and Metastasis

Insite: Arthritis Drugs Might Enhance Cancer Chemotherapy

Congratulations to Mi Young for her Gpr116 paper that made the May 2013 cover of Cell Reports


Congratulations to Amit for his 2012 Cancer Cell paper!

Bettegowda  C, Science Translational Medicine: Staying Alive: Specifically Targeting Tumor Vessels with Anti-Angiogenesis Therapy

Cain C. Science-Business eXchange:  A TEM to kill

CCR News: TEM8 May Be a Better Anti-Angiogenesis Target

Congratulations to Steve for his 2007 Cancer Cell paper!

Li JL, Harris AL, Cancer CellThe potential of new tumor endothelium-specific markers for the development of antivascular therapy

Robey, R. Nature Reviews Cancer: Angiogenesis: Hidden signatures written in blood    

NIH News Release: NCI Researchers Discover Genes That Are Turned On at High Levels in Tumor-Associated Blood Vessels of Mice and Humans

Cell Press Science News:  Tumor vessels identified by unique molecular markers

NIH Research Matters: Genes Turned on in Tumor-Associated Blood Vessels