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Brad  St. Croix, Ph.D.

Brad St. Croix, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Tumor Angiogenesis Unit

RESEARCH SUMMARY

Dr. St. Croix pioneered the development of methods to uncover molecules expressed on the tumor vasculature. He is now exploiting this new knowledge to better understand the process of new blood vessel formation, i.e. angiogenesis, and target the neovasculature that feeds tumors in order to develop more effective therapies for cancer. His recent studies describe the development of new therapeutic monoclonal antibodies that are non-toxic and have potential to aid in the management of cancer and other vascular diseases. The Tumor Angiogenesis Unit develops new approaches to detect and treat primary and metastatic disease through targeting of the tumor microenvironment.

Areas of Expertise

Tumor Angiogenesis
Endothelial Cell Biology
Vascular Biology
Tumor Endothelial Marker 8 (TEM8)/Anthrax Toxin Receptor 1 (ANTXR1)

Publications

Selected Publications

Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform

L Yang, TP Sheets, Y Feng, G Yu, P Bajgain, K-S Hsu, D So, S Seaman, J Lee, L Lin, CN Evans, MR Guest, R Chari, B St Croix
Sci Adv. 10(7): 2024.
Full-Text Article(link is external)
[ Journal Article ]

Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability

Yang Feng, Jaewon Lee, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Veera V Shivaji R Edupuganti, Kuo-Sheng Hsu, Christopher Dower, Guojun Yu, Daeho So, Pradip Bajgain, Zhongyu Zhu, Dimiter S Dimitrov, Nimit L Patel, Christina M Robinson, Simone Difilippantonio, Marzena Dyba, Amanda Corbel, Falguni Basuli, Rolf E Swenson, Joseph D Kalen, Sreedhar Reddy Suthe, Myer Hussain, James S Italia, Colby A Souders, Ling Gao, Martin J Schnermann, Brad St Croix
Cell Rep. 42: Online ahead of print, 2023.
Full-Text Article(link is external)
[ Journal Article ]

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo & Brad St. Croix
Nat Communications. 2022 Nov 18;13(1):7078. doi: 10.1038/s41467-022-34643-5.: 2022.
Full-Text Article(link is external)
[ Journal Article ]

Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.

Szot C, Saha S, Zhang XM, Zhu Z, Hilton MB, Morris K, Seaman S, Dunleavey JM, Hsu KS, Yu GJ, Morris H, Swing DA, Haines DC, Wang Y, Hwang J, Feng Y, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Dimitrov DS, St Croix B.
J Clin Invest.. Jun 4. pii: 120481. doi: 10.1172/JCI120481. [Epub ahead of print]: 1-17, 2018.
Full-Text Article(link is external)
[ Journal Article ]

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, Tessarollo L, Smith SW, Degrado S, Borkin D, Jain N, Scheiermann J, Feng Y, Wang Y, Li J, Welsch D, DeCrescenzo G, Chaudhary A, Zudaire E, Klarmann KD, Keller JR, Dimitrov DS, St Croix B
Cancer Cell. 31(4):501-515.e8. : 2017.
Full-Text Article(link is external)
[ Journal Article ]

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Team

Postdoctoral Fellow (Visiting)
Pradip Bajgain, Ph.D.
Biologist
Yang Feng, Ph.D.
Senior Research Assistant
Steven Seaman, MSc
Postdoctoral Fellow (Visiting)
Daeho So, Ph.D.
Postdoctoral Fellow (Visiting)
Liping Yang, Ph.D.
Postdoctoral Fellow (Visiting)
Jaewon Lee, Ph.D.
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