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headshot 2022 Nov

Peng Jiang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Data Science Laboratory

RESEARCH SUMMARY

Dr. Jiang's research is focused on developing integrative frameworks that leverage the big-data resource in public domains to identify regulators of cancer therapy resistance. A general challenge in cancer research is the lack of data to understand the clinical efficacy of each treatment, while new drugs with distinct mechanisms of action get approved every year. To fill in the gap, we are developing statistical and machine learning infrastructures that transfer knowledge from a vast amount of previous data cohorts to the study of new cancer biology problems.

Areas of Expertise

1) big data integration, 2) cancer genomics, 3) machine learning, 4) biostatistics, 5) precision medicine, 6) cancer immunotherapy

Publications

Selected Recent Publications

A T cell resilience model associated with response to immunotherapy in multiple tumor types

Zhang Y, Vu T, Palmer D, Kishton R, Gong L, Huang J, Nguyen T, Chen Z, Smith C, Livák F, Paul R, Day C, Wu C, Merlino G, Aldape K, Guan X, Jiang P
Nature Medicine. 28(7): 1421–1431, 2022.
Full-Text Article
[ Journal Article ]

Systematic investigation of cytokine signaling activity at the tissue and single-cell levels

Jiang P, Zhang Y, Ru B, Yang Y, Vu T, Paul R, Mirza A, Altan-Bonnet G, Liu L, Ruppin E, Wakefield L, Wucherpfennig KW
Nature Methods. 18(10): 1181–1191, 2021.
Full-Text Article
[ Journal Article ]

Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response

Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS.
Nature Medicine. 24(10): 1550-1558, 2018.
Full-Text Article
[ Journal Article ]

Big data in basic and translational cancer research

Jiang P, Sinha S, Aldape K, Hannenhalli S, Sahinalp C, Ruppin E
Nature Reviews Cancer. 2022.
Full-Text Article
[ Journal Article ]

SPICi: a fast clustering algorithm for large biological networks

Jiang P, Singh M
Bioinformatics. 26(8): 1105-1111, 2010.
Full-Text Article
[ Journal Article ]

Job Vacancies

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