Yousuke Takahama, Ph.D.

Yousuke Takahama, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch


The current interest of our laboratory is to understand molecular mechanisms (1) that build functionally competent thymus microenvironments, which are capable of supporting the production and selection of T cells, (2) that govern thymic selection to establish a functionally competent repertoire of mature T cells, and (3) that position developing T cells to localize within the thymus microenvironments for T cell repertoire formation.

Areas of Expertise

Thymus Biology
Thymic Epithelial Cells
Thymus Development
T Cell Development
T Cell Repertoire Selection


Selected Recent Publications

Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance

Ushio A, Matsuda-Lennikov M, Kalle-Youngoue F, Shimizu A, Abdelmaksoud A, Kelly MC, Ishimaru N, Takahama Y.
Cell Reports. 43: 114072, 2024.
Full-Text Article
[ Journal Article ]

Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

Ohigashi I, White AJ, Yang MT, Fujimori S, Tanaka Y, Jacques A, Kiyonari H, Matsushita Y, Turan S, Kelly MC, Anderson G, Takahama Y.
eLife. 12: 92552 , 2024.
Full-Text Article
[ Journal Article ]

The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection

Ohigashi I, Frantzeskakis M, Jacques A, Fujimori S, Ushio A, Yamashita F, Ishimaru N, Yin D, Cam M, Kelly MC, Awasthi P, Takada K, Takahama Y.
J Exp Med. 218: e20201904, 2021.
Full-Text Article
[ Journal Article ]

Trans-omics impact of thymoproteasome in cortical thymic epithelial cells

Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
Cell Reports. 29: 2901-2916, 2019.
Full-Text Article
[ Journal Article ]

Essential role of CCL21 in establishment of central self-tolerance in T cells

Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
J Exp Med. 214: 1925-1935, 2017.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Immunology, developmental biology Ph.D. or equivalent, M.D. or equivalent Yousuke Takahama


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