Yousuke Takahama, Ph.D.

Yousuke Takahama, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch


The current interest of our laboratory is to understand molecular mechanisms (1) that build functionally competent thymus microenvironments, which are capable of supporting the production and selection of T cells, (2) that govern thymic selection to establish a functionally competent repertoire of mature T cells, and (3) that position developing T cells to localize within the thymus microenvironments for T cell repertoire formation.

Areas of Expertise

Thymus Biology
Thymic Epithelial Cells
Thymus Development
T Cell Development
T Cell Repertoire Selection


Selected Recent Publications

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

Fujimori S, Ohigashi I, Abe H, Matsushita Y, Katagiri T, Taketo MM, Takahama Y, Takada S.
eLife. 11: e69088, 2022.
Full-Text Article
[ Journal Article ]

The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection

Ohigashi I, Frantzeskakis M, Jacques A, Fujimori S, Ushio A, Yamashita F, Ishimaru N, Yin D, Cam M, Kelly MC, Awasthi P, Takada K, Takahama Y.
J Exp Med. 218: e20201904, 2021.
Full-Text Article
[ Journal Article ]

Trans-omics impact of thymoproteasome in cortical thymic epithelial cells

Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin AC, Hoffmann V, Kozai M, Matsushita Y, Uda S, Motosugi R, Hamazaki J, Kubota H, Murata S, Tanaka K, Katagiri T, Kosako H, Takahama Y.
Cell Reports. 29: 2901-2916, 2019.
Full-Text Article
[ Journal Article ]

Essential role of CCL21 in establishment of central self-tolerance in T cells

Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y.
J Exp Med. 214: 1925-1935, 2017.
Full-Text Article
[ Journal Article ]

Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus

Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, and Takahama Y.
Nat Commun. 8: 14419, 2017.
Full-Text Article
[ Journal Article ]

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Alison Jacques, M.S.
Staff Scientist
Jie Li, Ph.D.
Postbaccalaureate Fellow
Jacqueline Battaile, M.S.


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