Senthil Muthuswamy

Senthil K. Muthuswamy, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Senthil Muthuswamy is an internationally renowned cancer biologist who pioneered the development and use of three-dimensional (3D) organoid culture and co-culture methods for mechanistic, translational, and co-clinical studies. Research from his laboratory helped define the role cell polarity proteins play in cancer biology and therapy resistance.

Areas of Expertise

1) organoid models 2) breast cancer 3) pancreatic cancer 4) cell polarity 5) immunotherapy 6) metastasis


Selected Key Publications

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK.
Nat Med. 21(11): 1364-71, 2015. [ Journal Article ]

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SK.
J Immunother Cancer. 9(11): e003213, 2021. [ Journal Article ]

Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis

Muthuswamy SK.
Cancer Cell. 39(4): 443-446, 2021. [ Journal Article ]

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK.
Cell. 135(5): 865-78, 2008. [ Journal Article ]

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer

Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK.
Nature. 569(7755): 275-279, 2019. [ Journal Article ]

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Postdoctoral Fellow (Visiting)
Weilin Li, Ph.D.
Research Technician
Dipikaa Akshinthala, M.S.