Headshot of Masashi Watanabe

Masashi Watanabe, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch


Dr. Watanabe is an immunologist and staff scientist in the Neuro-Oncology Branch (NOB) Translational Immunology Research Program. He is interested in understanding how the immune system interacts with brain tumors and their microenvironment. His research goal is to develop novel immunotherapeutic strategies to treat brain cancer.

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Areas of Expertise

1) Immunology 2) Immuno-oncology 3) Cell biology 4) Molecular biology


Selected Recent Publications

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

Watanabe M, Lu Y, Breen M, Hodes RJ.
Nature Communications. 11(1): 1-14, 2020. [ Journal Article ]

TCR Repertoires of Thymic Conventional and Regulatory T Cells: Identification and Characterization of Both Unique and Shared TCR Sequences

Ko A, Watanabe M, Nguyen T*, Shi A, Achour A, Zhang B, Sun X, Wang Q, Zhuang Y, Weng NP, Hodes RJ.
Journal of Immunology. 204(4): 858-867, 2020. [ Journal Article ]

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK, McGavern DB, Bosselut R.
Immunity. 51(3): 465-478, 2019. [ Journal Article ]

Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells

Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ.
Journal of Experimental Medicine. 214(9): 2795-2810, 2017. [ Journal Article ]

Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses

Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ.
Immunity. 40(5): 681-691, 2014. [ Journal Article ]