Breadcrumb

Claudia M. Palena, Ph.D.

Claudia M. Palena, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

This group investigates mechanisms of tumor progression, including mechanisms of metastasis and tumor resistance to therapies, and how immune-based therapies can be employed as therapeutics directed against such tumor-cell phenotypes.

Dr. Palena’s research focuses on the immunological targeting of drivers of tumor metastasis and resistance to therapy. Her recent studies on a novel tumor-associated antigen, the transcription factor brachyury, have led to the rapid translation of 3 cancer vaccine platforms targeting a driver of the epithelial-mesenchymal transition, a process associated with cancer progression, from basic discovery to Phase I and II clinical studies. As the Head of the Tumor Immunoregulation Section, Dr. Palena continues to investigate innovative immunotherapeutic approaches that may be used in combination with other anti-neoplastic agents to generate anti-tumor immune responses that could alleviate metastatic disease in cancer patients.

Areas of Expertise

1) tumor immunology, 2) immunotherapy, 3) cancer vaccines, 4) metastasis,
5) tumor resistance

Publications

Selected Recent Publications

Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-beta signaling enables PD-L1-mediated tumor eradication

Horn LA, Chariou PL, Gameiro SR, Qin H, Iida M, Fousek K, Meyer TJ, Cam M, Flies D, Langermann S, Schlom J, and Palena C.
J Clin Invest.. 132(8): e155148, 2022.
Full-Text Article
[ Journal Article ]

Interleukin-8: a chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

Fousek K, Horn LA, Palena C.
Pharmacol Ther.. 219: 107692, 2021.
Full-Text Article
[ Journal Article ]

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

Horn LA, Riskin J, Hempel HA, Fousek K, Lind H, Hamilton DH, McCampbell KK, Maeda DY, Zebala JA, Su Z, Schlom J, Palena C.
J Immunother Cancer. 8(1): e000326, 2020. [ Journal Article ]

Tumor plasticity and resistance to immunotherapy

Horn LA, Fousek K, Palena C.
Trends Cancer. 6(5): 432-41, 2020. [ Journal Article ]

Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer

Dominguez C, McCampbell KK, David JM, Palena C.
JCI Insight. 2(21): e94296, 2017. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Madeline Dahut
Predoctoral Fellow (IRTA)
Madeline Dahut
Kristen Fousek
Postdoctoral Fellow (CRTA)
Kristen Fousek, Ph.D.
Masafumi Iida
Postdoctoral Fellow (Visiting)
Masafumi Iida, M.D., Ph.D.
Haiyan Qin
Biologist
Haiyan Qin
Postbaccalaureate Fellow
Dan Yacubovich