Lucas A. Horn, Ph.D.

Lucas A. Horn, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology


Dr. Horn’s current research involves the development of innovative combination therapies for the treatment of cancer. His focus is on understanding mechanisms of tumor progression and therapy resistance, including the influence of tumor cell plasticity and the tumor extracellular matrix on immune cells in the tumor microenvironment.

Areas of Expertise

Tumor Immunology
Cancer Immunotherapy
Tumor Progression
Tumor Resistance To Therapy
Cancer Vaccines


Selected Recent Publications

Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-beta signaling enables PD-L1-mediated tumor eradication

Horn LA, Chariou PL, Gameiro SR, Qin H, Iida M, Fousek K, Meyer TJ, Cam M, Flies D, Langermann S, Schlom J, Palena C.
J Clin Invest. 132(8): e155148, 2022.
Full-Text Article
[ Journal Article ]

Tumor plasticity and resistance to immunotherapy

Horn LA, Fousek K, Palena C.
Trends Cancer. 6(5): 432-441, 2020. [ Journal Article ]

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

Horn LA, Riskin J, Hempel HA, Fousek K, Lind H, Hamilton DH, McCampbell KK, Maeda DY, Zebala JA, Su Z, Schlom J, Palena C.
J Immunother Cancer. 8(1): e000326, 2020. [ Journal Article ]

Vaccine increases the diversity and activation of intratumoral T cells in the context of combination immunotherapy

Horn LA, Fousek K, Hamilton DH, Hodge JW, Zebala JA, Maeda, DY, Schlom J, Palena C.
Cancers. 13(5): 968, 2021.
Full-Text Article
[ Journal Article ]

The use of a humanized NSG-β2m -/- model for investigation of immune and anti-tumor effects

Morillon YM II, Smalley Rumfield C, Pellom ST, Sabzevari A, Roller NT, Horn LA, Jochems C, Palena C, Greiner JW, Schlom J.
Front Oncol. 10: 1548, 2020. [ Journal Article ]