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Kandice Tanner, Ph.D.

Kandice Tanner, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cell Biology

RESEARCH SUMMARY

The Tanner lab focuses on understanding the metastatic traits that allow tumor cells to colonize secondary organs. Our interdisciplinary team includes physicists, engineers and cancer biologists. We have determined that cells can switch between different types of motility namely rotation, random and amoeboid when placed in 3D biomimetic platforms. We have linked the type of motility to the establishment of distinct multicellular architectures and tissue polarity. We leverage our expertise in optical microscopy to uncover in vivo mechanisms of metastasis using zebrafish as an animal model. Our current studies are focused on understanding how physical cues from the tissue microenvironment drive organ specific metastasis.

Areas of Expertise

1) multimodal imaging platforms, 2) 3D cell culture, 3) biophysics, 4) mechanobiology, 5) breast cancer

Publications

Selected Recent Publications

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish.

Paul, C., Bishop, K., Devine, A., Paine, E., Staunton, J., & Thomas, S., Jenkins, L., Morgan, N., Sood, R., Tanner, K
Cell Systems. 9(2): 187-206.e16, 2019. [ Journal Article ]

High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics

Staunton, J., So, W., Paul, C., & Tanner, K
Proc Natl Acad Sci U S A. 116(29): 14448-14455, 2019. [ Journal Article ]

Independent control of topography for three-dimensional patterning of the ECM microenvironment

Kim J, Staunton JR, and Tanner K.
Adv Mater. Jan 6;28(1) Epub 2015 Nov 9.: 132-7, 2016. [ Journal Article ]

Beyond 3D culture models

Tanner K and Gottesman MM.
Science Trans. Med. 7: 283ps9, 2015. [ Journal Article ]

Coherent angular motion in the establishment of multicellular architecture of glandular tissues

Tanner K, Mori H, Mroue R, Bruni-Cardoso A, and Bissell MJ.
Proc. Natl. Acad. Sci. U.S.A. 109: 1973-8, 2012. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Zebrafish, tissue microenvironment, metastasis Ph.D. or equivalent Kandice Tanner kandice.tanner@nih.gov
Post-baccalaureate Fellow - Bioengineering, metastasis, imaging B.S./B.A. or equivalent Kandice Tanner kandice.tanner@nih.gov

Team

Visiting Post-doctoral Fellow
Udochi F Azubuike, Ph.D.
Predoctoral Fellow (NIH Oxford-Cambridge Scholars Program)
Amelia Foss
Pre-doctoral Visiting Fellow (Graduate Student)
Hyeyeon Gong
Biologist
Patricia Gordon
Post-bac Fellow
Christian Haryanto, MS
Graduate student, NIH Comparative Biomedical Scientist Training Program
Chaunte Lewis, DVM
Postdoctoral Fellow (CRTA)
Woong Young So, Ph.D.