Michael Lichten headshot

Michael Lichten, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Lichten’s research uses budding yeast as a model system to study mechanisms that protect and maintain genome integrity. His group studies how DNA repair, homologous recombination and the DNA damage response function during meiosis and during the mitotic cell cycle. A main focus is on mechanisms and regulation of homologous recombination during meiosis, with an emphasis on the relationship between recombination, recombination, and chromatin/chromosome structure and dynamics.

Areas of Expertise

1) homologous recombination, 2) DNA repair, 3) meiosis, 4) chromatin, 5) chromosome structure, 6) Saccharomyces cerevisiae


Selected Recent Publications

Repeated strand invasion and extensive branch migration are hallmarks of meiotic recombination

Ahuja JS, Harvey CS, Wheeler DL, LichtenM.
Molecular Cell. 81: 4258-4270, 2021.
Full-Text Article
[ Journal Article ]

Unresolved Recombination Intermediates Cause a RAD9-Dependent Cell Cycle Arrest in Saccharomyces cerevisiae

Kaur H, Gn K, Lichten M.
Genetics. 213(3): 805-818, 2019. [ Journal Article ]

Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers During Saccharomyces cerevisiae Meiosis

Anura Shodhan
Darpan Medhi
Michael Lichten
G3 Genes|Genomes|Genetics. 9: 1647-1654, 2019.
Full-Text Article

Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis

Medhi D, Goldman AS, Lichten M.
eLife. 5: e19669, 2016. [ Journal Article ]

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