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Jadranka  Loncarek, Ph.D.

Jadranka Loncarek, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. Loncarek studies the fundamentals centrosome biology. Centrosomes are cellular organelles that mediate vital cellular processes such as cell division, signaling, motility, and development. Centrosome aberrations are a hallmark of tumors and cilia related diseases. Her lab aims to elucidate how centrosome biogenesis is controlled and coordinated with other cell cycle events in healthy and pathological conditions, and how centrosomes are organized in nanoscale resolution. In her work, she combines molecular biology, biochemistry, and genetics with cutting-edge microscopy approaches such as super resolution microscopy and correlative light and electron microscopy.

Areas of Expertise

1) Centrosome, 2) Centriole, 3) Cell cycle 4) Super Resolution Microscopy, 5) Transmission Electron Microscopy

Publications

Selected Key Publications

Prolonged mitosis results in structurally aberrant and over-elongated centrioles

Kong D, Sahabandu N, Sullenberger C, Vásquez-Limeta A, Luvsanjav D, Lukasik K, Loncarek J
J Cell Biol. 219(6): 2020. [ Journal Article ]

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

Bowler M, Kong D, Sun S, Nanjundappa R, Evans L, Farmer V, Holland A, Mahjoub MR, Sui H, Loncarek J
Nat Commun . Mar 1; 10 (1): 993, 2019. [ Journal Article ]

Expansion microscopy for the analysis of centrioles and cilia

Sahabandu N, Kong D, Magidson V, Nanjundappa R, Sullenberger C, Mahjoub MR, Loncarek J.
J of Microscopy. 277(3): 210, 2019. [ Journal Article ]

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles

Kong D, Farmer V, Shukla A, James J, Gruskin R, Kiriyama S, Loncarek J
J Cell Biol. 206(7): 855-65, 2014. [ Journal Article ]

Control of daughter centriole formation by the pericentriolar material

Loncarek J, Hergert P, Magidson V, Khodjakov A
Nat Cell Biol. 10(3): 322-8, 2008. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Cell biology, centrosome, cell cycle Ph.D. or equivalent Jadranka Loncarek jadranka.loncarek@nih.gov

Team

Staff Scientist
Dong Kong, Ph.D.
Scientist II (Contr.)
Delgermaa Luvsanjav, Ph.D.
Postdoctoral Fellow (CRTA)
Catherine Sullenberger, Ph.D.
Postdoctoral Fellow (Visiting)
Alejandra Vasquez Limeta, Ph.D.
POSTBACCALAUREATE FELLOW
Pegah Avazpour, B.S.
POSTBACCALAUREATE FELLOW
Thomas Janas, B.S.

Alumni

Anil Shukla
Anil Shukla
2012-2016
Postdoc
Dong Kong
Dong Kong
2012 - 1017 postdoc, 2017- Staff Scientist
Postdoc
Veronica Farmer
Veronica Farmer
2012, 2013-2015
Summer student and Postbac
Meena Sharma
Meena Sharma
2013-2016
Postbac
Jana James
Jana James
2012-2013
Postbac
Matthew Bowler
Matthew Bowler
2016-2018
Postbac
Natalie Sahabandu
Natalie Sahabandu
2018-2019
Postbac
Kristina Cronise
Kristina Cronise
2016-2017
Postbac
Kimberly Lukasik
Kimberly Lukasik
2018-2020
Postbac
Amil Sahai
Amil Sahai
2014
Summer student
Susan Dang
Susan Dang
2017-2018
Postbac
Sett Naing
Sett Naing
2015
Summer student
Vignesh Rajasekaran
Vignesh Rajasekaran
2015
Summer student
Sylvana Aho
Sylvana Aho
2017
Summer student
Ovais Hasan
Ovais Hasan
2018
Summer student