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Profile photo of Christopher B. Buck, Ph.D.

Christopher B. Buck, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cellular Oncology

RESEARCH SUMMARY

Work in our lab revolves around the virion proteins of a family of viruses called polyomaviruses. Our research ranges from basic investigation of the mechanisms through which polyomaviruses infect cells to translational development of virus-like particle vaccines. We also maintain an active interest in discovering new virus species, with the goals of uncovering human disease associations and understanding the evolutionary history of cancer-causing viruses.

Areas of Expertise

1) polyomavirus 2) papillomavirus 3) microbiome 4) vaccine 5) infectious entry 6) evolutionary biology

Publications

Selected Recent Publications

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

Peretti A, Geoghegan EM, Pastrana DV, Smola S, Feld P, Sauter M, Lohse S, Ramesh M, Lim ES, Wang D, Borgogna C, FitzGerald PC, Bliskovsky V, Starrett GJ, Law EK, Harris RS, Killian JK, Zhu J, Pineda M, Meltzer PS, Boldorini R, Gariglio M, Buck CB
Cell Host Microbe. 2018 May 9: 23(5):628-635.e7. doi: 10.1016/j.chom.2018.04.005, 2018. [ Journal Article ]

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Geoghegan EM, Pastrana DV, Schowalter RM, Ray U, Gao W, Ho M, Pauly GT, Sigano DM, Kaynor C, Cahir-McFarland E, Combaluzier B, Grimm J, Buck CB
Cell Rep.. 2017 Oct 31: 31;21(5):1169-1179. doi: 10.1016/j.celrep.2017.10.027, [ Journal Article ]

JC polyomavirus mutants escape antibody-mediated neutralization

Ray U, Cinque P, Gerevini S, Longo V, Lazzarin A, Schippling S, Martin R, Buck CB, Pastrana DV.
Sci Transl Med. 7(306): 306ra151, 2015. [ Journal Article ]

A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

Michael J. Tisza and Christopher B. Buck
PNAS. 118: e2023202118, 2021.
Full-Text Article
[ Journal Article ]

The case for BK polyomavirus as a cause of bladder cancer

Gabriel J. Starrett and Christopher B. Buck
Curr Opin Virol. 39: 8-15, 2019.
Full-Text Article
[ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Senior Technical Laboratory Manager
Diana V. Pastrana, Ph.D.
Postbaccalaureate Fellow (CRTA)
Ria Almohtadi