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Picture of Diana Pastrana at her desk

Diana V. Pastrana, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cellular Oncology

RESEARCH SUMMARY

Dr. Pastrana's projects in LCO have been related to the humoral response to papilloma and polyomaviruses.  She has developed neutralization assays for many of these viruses. In addition, she has participated in the discovery of dozens of novel papillomaviruses and a few polyomavirus types.  Her work has directly lead to the development of a polyomavirus vaccine which will soon be tested in clinical trials for prevention of nephropathy in kidney transplant patients.  

Areas of Expertise

1) Cancer and Viruses 2) Polyomaviruses 3) Virus Neutralization 4) Virus Discovery 5) Papillomaviruses 

Publications

Selected Recent Publications

Adintoviruses: a proposed animal-tropic family of midsize eukaryotic linear dsDNA (MELD) viruses.

Gabriel J Starrett, Michael J Tisza, Nicole L Welch, Anna K Belford, Alberto Peretti, Diana V Pastrana, Christopher B Buck
Virus Evolution. 7(1): veaa055, 2021.
Full-Text Article
[ Journal Article ]

Host-Pathogen Interactions in Human Polyomavirus 7‒Associated Pruritic Skin Eruption.

Rachel K.Rosenstein, Diana V.Pastrana, Gabriel J.Starrett, Matthew R.Sapio, Natasha T.Hill, Jay-HyunJo, Chyi-Chia R.Lee, Michael J.Iadarola, Christopher B.Buck, Heidi H.Kong, IsaacBrownell, Edward W.Cowen
Journal of Investigative Dermatology. 141(5): 1344-1348.e8, 2021.
Full-Text Article
[ Journal Article ]

Discovery of several thousand highly diverse circular DNA viruses

Michael J Tisza, Diana V Pastrana, Nicole L Welch, Brittany Stewart, Alberto Peretti, Gabriel J Starrett, Yuk-Ying S Pang, Siddharth R Krishnamurthy, Patricia A Pesavento, David H McDermott, Philip M Murphy, Jessica L Whited, Bess Miller, Jason Brenchley, Stephan P Rosshart, Barbara Rehermann, John Doorbar, Blake A Ta'ala, Olga Pletnikova, Juan C Troncoso, Susan M Resnick, Ben Bolduc, Matthew B Sullivan, Arvind Varsani, Anca M Segall, Christopher B Buck
eLife. 2020.
Full-Text Article
[ Journal Article ]

Plerixafor for the Treatment of WHIM Syndrome

David H. McDermott, M.D., Diana V. Pastrana, Ph.D., Katherine R. Calvo, M.D., Ph.D., Stefania Pittaluga, M.D., Ph.D., Daniel Velez, M.S.N., Elena Cho, M.S.N., Qian Liu, M.D., Hugh H. Trout, III, M.D., João F. Neves, M.D., Pamela J. Gardner, D.M.D., David A. Bianchi, M.D., Elizabeth A. Blair, M.D., Emily M. Landon, M.D., Susana L. Silva, M.D., Ph.D., Christopher B. Buck, Ph.D., and Philip M. Murphy, M.D.
N Engl J Med.. 380(2): 163-170, 2019.
Full-Text Article
[ Journal Article ]

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency

Diana V. Pastrana, Alberto Perettia, Nicole L. Welch, Cinzia Borgogna, Carlotta Olivero, Raffaele Badolato, Lucia D. Notarangelo, Marisa Gariglio, Peter C. FitzGerald, Carl E. McIntosh, Jesse Reeves, Gabriel J. Starrett, Valery Bliskovsky, Daniel Velez, Isaac Brownell, Robert Yarchoan, Kathleen M. Wyvill, Thomas S. Uldrick, Frank Maldarelli, Andrea Lisco, Irini Sereti, Christopher M. Gonzalez, Elliot J. Androphy, Alison A. McBride, Koenraad Van Doorslaer, Francisco Garcia, Israel Dvoretzky, Joceline S. Liu, Justin Han, Philip M. Murphy, David H. McDermott, Christopher B. Buck
mSphere. 3(6): e00645-18, 2018.
Full-Text Article
[ Journal Article ]