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Jennifer Clare Jones, M.D., Ph.D.

Jennifer Clare Jones, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology

RESEARCH SUMMARY

Dr. Jones (McIntire) positionally cloned the TIM gene family and demonstrated the genetic association between TIMs and immune response profiles (McIntire et al., Nature Immunology 2001, and Nature 2003). As a radiation oncologist, her current research is focused on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Dr. Jones is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a translational EV analysis pipeline, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Current Translational Nanobiology Lab information, software, and protocols are found at our lab website: https://nano.ccr.cancer.gov/

Areas of Expertise

1) tumor immunology, 2) radiobiology, 3) (nano) flow cytometry, 4) nanoscale particle analysis (particularly exosomes, microparticles, and other extracellular vesicles), 5) immune receptor immunogenetics and evolution, 6) vaccine and immunotherapy development

Publications

Selected Recent Publications

Prospective Use of High-Refractive Index Materials for Single Molecule Detection in Flow Cytometry

Welsh JA, Kepley J, Rosner A, Horak P, Berzofsky JA, Jones JC.
Sensors. 18(8): 2461, 2018. [ Journal Article ]

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, and Jones JC.
Sci Rep. 7(1): 1878, 2017. [ Journal Article ]

Detection of platelet vesicles by flow cytometry

Nolan JP, Jones JC.
Platelets. 28(3): 256-262, 2017. [ Journal Article ]

Flow Cytometric Analysis of Extracellular Vesicles

Morales-Kastresana A, Jones JC.
Methods Mol Biol. 1545: 215-225, 2017. [ Journal Article ]

Flow virometric sorting and analysis of HIV quasispecies from plasma

Musich T, Jones JC, Keele BF, Jenkins LM, Demberg T, Uldrick TS, Yarchoan R, and Robert-Guroff M.
JCI Insight. 2(4): e90626, 2017. [ Journal Article ]

Job Vacancies

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