Jennifer Clare Jones, M.D., Ph.D.

Jennifer Clare Jones, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


Dr. Jones (McIntire) positionally cloned the TIM gene family and demonstrated the genetic association between TIMs and immune response profiles (McIntire et al., Nature Immunology 2001, and Nature 2003). As a radiation oncologist, her current research is focused on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Dr. Jones is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a translational EV analysis pipeline, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Current Translational Nanobiology Lab information, software, and protocols are found at our lab website:

Areas of Expertise

Nano Flow Cytometry
Nanoscale Particle Analysis (particularly exosomes, microparticles, and other extracellular vesicles)
Immune Receptor Immunogenetics and Evolution


Selected Publications

A Compendium of EV Flow Cytometry

Welsh, JA, Arkesteijn GJ, Bremer M, Cimorelli M, Dignat-George F, Giebel B, Görgens A, Hendrix A, Kuiper M, Lacroix R, Lannigan J, van Leeuwen TG, Lozano Andrés E, Rao S, Robert S, de Rond L, Tang VA, Tertel T, Yan X, Wauben MHM, Nolan J*, Jones JC*, Nieuwland R*, van der Pol E* (*co-senior and co-corresponding)
Journal of Extracellular Vesicles. 2023.
Full-Text Article
[ Journal Article ]

The NanoFlow Repository

Arce JE, Welsh JA, Cook S, Tigges J, Ghiran I, Jones JC, Jackson A, Roth M, Milosavljevic A.
Bioinformatics. 2023.
Full-Text Article
[ Journal Article ]

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, and Jones JC.
Sci Rep. 7(1): 1878, 2017.
Full-Text Article
[ Journal Article ]

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer

Morales-Kastresana A, Musich TA, Welsh JA, Telford W, Demberg T, Wood JCS, Bigos M, Ross CD, Kachynski A, Dean A, Felton EJ, Van Dyke J, Tigges J, Toxavidis V, Parks DR, Overton WR, Kesarwala AH, Freeman GJ, Rosner A, Perfetto SP, Pasquet L, Terabe M, McKinnon K, Kapoor V, Trepel JB, Puri A, Kobayashi H, Yung B, Chen X, Guion P, Choyke P, Knox SJ, Ghiran I, Robert-Guroff M, Berzofsky JA, Jones JC.
Journal of Extracellular Vesicles. 2019.
Full-Text Article
[ Journal Article ]

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

Welsh JA, Van Der Pol E, Arkesteijn GJA, Bremer M, Brisson A, Coumans F, Dignat-George F, Duggan E, Ghiran I, Giebel B, Görgens A, Hendrix A, Lacroix R, Lannigan J, Libregts SFWM, Lozano-Andrés E, Morales-Kastresana A, Robert S, De Rond L, Tertel T, Tigges J, De Wever O, Yan X, Nieuwland R, Wauben MHM, Nolan JP, Jones JC.
Journal of Extracellular Vesicles. 2020.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Jason Savage, MS
iCure Postdoctoral Fellow
Stephanie Chidester, PhD
Post-baccalaureate Fellow
Jubin George, BS
Post-baccalaureate Fellow
Michelle Luo, BS


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