Amiran Dzutsev

Amiran K. Dzutsev, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


I am a cancer immunologist with a keen interest in systems biology and the microbiome. My research focuses on understanding the impact of microbiota on cancer development, progression, and responses to therapy.

My lab's work aims to shed light on the intricate interactions between the microbiome, immune system and cancer, ultimately contributing to the development of more effective therapeutic strategies.

Areas of Expertise


Selected Recent Publications

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, Balaji AK, Vetizou M, Prescott SM, Fernandes MR, Costa RGF, Yuan W, Salcedo R, Bahadiroglu E, Roy S, DeBlasio RN, Morrison RM, Chauvin JM, Ding Q, Zidi B, Lowin A, Chakka S, Gao W, Pagliano O, Ernst SJ, Rose A, Newman NK, Morgun A, Zarour HM, Trinchieri G, Dzutsev AK.
Nature Medicine. 28(3): 545-556, 2022. [ Journal Article ]

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM.
Science. 371(6529): 595-602, 2021. [ Journal Article ]

Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
Science. 342(6161): 967-70, 2013. [ Journal Article ]

Microbes and Cancer

Dzutsev A, Badger JH, Perez-Chanona E, Roy S, Salcedo R, Smith CK, Trinchieri G.
Annu Rev Immunology. 26(35): 199-228, 2017. [ Journal Article ]

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Research Fellow
Poonam Aggarwal, Ph.D.


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