Urologic Oncology Branch
Information for Patients
Learn more about our clinical trials and the highly specialized care teams who lead them.
The Urologic Oncology Branch conducts clinical and basic research designed to develop better methods for detecting, preventing, and treating patients with kidney cancer, prostate cancer and bladder cancer. We evaluate and manage patients with non-inherited as well as inherited forms of kidney cancer. The Branch also has an expanding prostate cancer program. Patients with known or suspected localized and locally advanced prostate cancer undergo advanced MRI imaging followed by fusion image-guided biopsy to diagnose and characterize the cancer. They may then be managed with robotic surgery or be followed with active surveillance and intermittent imaging. In addition, we have a growing program in genomics and targeted therapy for bladder cancer patients, including therapy that targets EGFR, FGFR3 and other mutated bladder cancer genes.
|Position||Degree Required||Contact Name||Contact Email|
|Clinical Fellow - urology, oncology, fellowship, training||M.D. or equivalent||Peter Pintoemail@example.com|
|Clinical Research Physician - Kidney cancer, medical oncology||M.D. or equivalent||Margot Michelsfirstname.lastname@example.org|
Molecular Genetic Analysis of Genetic Events Associated With Initiation and Progression of Urologic Malignancies. Dr. Linehan and his team identified the genes for the common forms of kidney cancer and described the pathways of these kidney cancer genes. Recent studies targeting the metabolic basis of kidney cancer have resulted in the regression of metastatic cancer in patients with type 1 and type 2 papillary kidney cancer.
Identifying Molecularly Targeted Therapeutic Approaches to Modulate Cancer Cell Growth and Survival. Dr. Neckers’ laboratory is investigating novel intracellular targets for specific pharmacologic intervention. For the last several years, his research has focused on 1) understanding the biologic activity of chaperone proteins, particularly HSP90, in mediating signal transduction in cancer cells, and 2) promoting the translational development of HSP90 inhibitors as novel anti-cancer agents.
Developing Novel Diagnostic and Treatment Modalities for Localized and Locally Advanced Prostate Cancer. Dr. Pinto’s research centers on the investigation of multiparametric MRI (mpMRI) in prostate cancer to improve diagnosis with mpMRI whole-mount pathology correlation and creation of a tumor-directed biopsy device; development of image-guided focal prostate cancer therapy; and evaluation of immunotherapy, molecularly targeted therapy or other pharmacotherapies in the management of localized or locally advanced prostate cancer.
Investigating Molecularly Targeted Therapeutics for Kidney Cancer. Dr. Srinivasan is developing treatment strategies and clinical trials for patients with both hereditary and non-hereditary forms of kidney cancer. Currently, his team is investigating a variety of newer 'targeted' agents in clear cell and papillary kidney cancer, as well as hereditary kidney cancer syndromes such as von Hippel-Lindau, hereditary leiomyomatosis and renal cell cancer (RCC) and hereditary papillary renal cell cancer (HPRC).
Clinical Programs Overview
Our physicians study families who have rare inherited conditions which predispose to development of kidney cancer. We also see patients without a positive family history who are suspected to have one of these rare genetic conditions. It is the study of these patients and their family members that allow the discovery of new genetic conditions, the responsible genes and new understanding that is the foundation of this Branch and has allowed the successes of the Branch. The clinical team is comprised of one genetic counselor/ protocol manager, nurse practitioners, clinical research nurses and patient care coordinators. Several populations of patients are evaluated for sporadic renal and bladder cancer, sporadic prostate cancer, familial kidney cancer, and interventional clinical trials.
Molecular Therapeutics translates discoveries at the genetic, molecular and cellular levels into improvements in the diagnosis and treatment of genitourinary (GU) cancers by defining genetically identified oncogenic signaling pathways, identifying new therapeutic targets and strategies, and conducting preclinical and clinical drug and biomarker development. We believe that successful therapeutic strategies to treat GU cancers will require understanding how cancer-associated signaling defects affect cell and organ function, as well as the development of appropriate reagents, bioassays, and cell and animal models for pathway analysis, drug design and testing.
Our Physician Assistants and Nurse Practitioners
Rebecca Dolan, N.P., Anju Johnson, CRNP, Seong Ko, CRNP, AGPCNP-C, Lisa Mac, PA-C, MPH, Beth Ryan, P.A.-C, Nana Yaqub-Ogun, P.A., Maria Zumer, PA-C
Our Patient Care Coordinators
Alexander Banks, Mabel Cruz, Stefania Misul, Luis Nunez, Patricia Vanags, Yvonne Wall
Our Research and Registered Nurses
Brooke Augustine, R.N., Wanda Bell-Farrell, MS, R.N., Sonia Bellfield, R.N., Tonesia Gross, R.N., Jill Harper M.S., Ph.D., N.R., Debbie Nielsen, B.S.N., CCRP, Lidenys O’Brien, R.N.
Our Urologic Oncology Fellows
Charles Hesswani, M.D., Alexander Kenigsberg, M.D., Christopher Koller, M.D., Keith Lawson, M.D., Ph.D., Neil Mendhiratta, M.D., M.S., Daniel Nethala, M.D.
Our Medical Research Students
William Azar, Jessica Hsueh, Nityam Rathi, Kyle Schuppe
Our Programmer, Data Managers, and Imaging Specialist
Kristin Choo, Donna Drake, Rabindra Gautam
Our Tissue Processing Facility
Cathy Vocke, Ph.D., Julian Custer, Krista Reynolds
Our Administrative Staff
Sunny Grimes, Margot Michels, Sophia Fajardo Michels, Rose Jochum, Malcolm Sawyer
Training opportunities are available in both clinical and basic research areas within the Branch.
- Urologic Oncology Fellowship (2 to 3-year SUO fellowship applicants)
- NIH Medical Research Scholars Program (1-year program for medical students)
- NIH Clinical Electives Program: Urologic Oncology (3rd & 4th year medical students, short-term)
- Postdoctoral Research Training Program in Urologic Oncology
- Training Opportunities for Students
- Predoctoral Fellowships
- NIH Graduate Student Partnership Program
- NIH Postbaccalaureate Program
- NIH Summer Internship Program in Biomedical Research