W. Marston  Linehan, M.D.

W. Marston Linehan, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Linehan pioneered the study of the genetic basis of kidney cancer. His team identified the genes for the common forms of kidney cancer and described the pathways of these kidney cancer genes. His recent studies targeting the metabolic basis of kidney cancer have resulted in the regression of metastatic cancer in patients with type 1 and type 2 papillary kidney cancer. As Chief, Dr. Linehan oversees the Branch’s clinical/translational research program, which emphasizes new approaches to the therapies of genitourinary cancers, diagnostic and prognostic evaluation of solid GU tumors, and the development of innovative surgical and adjunctive approaches to the treatment of patients with primary and metastatic urologic cancer.

Areas of Expertise

VHL Gene
Targeted Therapy
Metabolic Therapy
Clear Cell Kidney Cancer

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Key Publications

Identification of the von Hippel-Lindau disease tumor suppressor gene

Latif F, Tory K, Gnarra JR, Yao M, Duh F-M, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt LS, Zhou F, Li H, Wei MH, Chen F, Glenn GM, Choyke P, Walther MM, Weng Y, Duan D-SR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault CA, Maher ER, Linehan WM, Zbar B, Lerman MI
Science. 260: 1317-20, 1993. [ Journal Article ]

The Warburg effect in hominis: isotope-resolved metabolism in ccRCC

Crooks DR, Linehan WM.
Nat Rev Urol. 15(12): 731-2, 2018. [ Journal Article ]

The Metabolic Basis of Kidney Cancer

Linehan WM, Schmidt LS, Crooks DR, Wei D, Srinivasan R, Lang M, Ricketts CJ.
Cancer Discov. 9(8): 1006-21, 2019. [ Journal Article ]

A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor

Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC.
Clin Cancer Res. 25(21): 6302-08, 2019. [ Journal Article ]

Growth Rates of Genetically Defined Renal Tumors: Implications for Active Surveillance and Intervention

Ball MW, An JY, Gomella PT, Gautam R, Ricketts CJ, Vocke CD, Schmidt LS, Merino MJ, Srinivasan R, Malayeri AA, Metwalli AR, Linehan WM.
J Clin Oncol. 38(11): 1146-53, 2020. [ Journal Article ]

Job Vacancies

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Nurse Practitioner (Contr.)
Rebecca Dolan, N.P.
Assistant Research Physician
Sandeep Gurram, M.D.
Clinical Fellow
Charles Hesswani, M.D.
Clinical Fellow
Alexander Kenigsberg, M.D.
Clinical Fellow
Christopher Koller, M.D.
Special Volunteer
Martin Lang, Ph.D.
Clinical Fellow
Keith Lawson, M.D., Ph.D.
Clinical Fellow
Neil Mendhiratta, M.D., M.S.
Clinical Fellow
Daniel Nethala, M.D.
Research Nurse
Debbie Nielsen, R.N.
Research Nurse
Lidenys O’Brien Gutierrez, R.N., B.S.N
Adjunct Investigator
Tracey A. Rouault, M.D.
Patient Care Coordinator (Contr.)
Patricia Vanags
Research Biologist
Ming-Hui Wei
Adjunct Investigator
Brad J. Wood, M.D.
Postdoctoral Fellow (Visiting)
Ye Yang, Ph.D.
Senior Technical Laboratory Manager
Youfeng Yang, M.S.