Breadcrumb

Christopher J. Ricketts, Ph.D.

Christopher J. Ricketts, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Urologic Oncology Branch

RESEARCH SUMMARY

Dr. Ricketts studies the genetics and genomics of renal cell carcinoma (RCC) in patients with inherited RCC syndromes, using multiple 'omics technologies to investigate both patient-derived tumors and cell line models.  He is part of the Branch's research program to understand the biology behind the genes that are mutated in inherited RCC syndromes and use this data to identify tumor-specific weaknesses that can be exploited by targeted therapies.

Areas of Expertise

1) genetics of familial renal cell carcinoma (RCC) syndromes, 2) genetic analysis of sporadic renal cell carcinoma, 3) epigenetic dysregulation of cancer by promoter hypermethylation, 4) altered tumor metabolism

Publications

Selected Key Publications

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, et al.
Cell Reports. 23(1): 313-326.e5, 2018. [ Journal Article ]

Comprehensive Molecular Characterization of Papillary Renal Cell Carcinoma

Cancer Genome Altas Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, et al.
New Engl J Med. 374(2): 135-45, 2016. [ Journal Article ]

The somatic genomic landscape of chromophobe renal cell carcinoma

Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, et al.
Cancer Cell. 26(3): 319-30, 2014. [ Journal Article ]

Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM.
Cancer Cell. 26(6): 840-50, 2014. [ Journal Article ]

Germline SDHB mutations and familial renal cell carcinoma

Ricketts C, Woodward ER, Killick P, Morris MR, Astuti D, Latif F, Maher ER.
J Natl Cancer Inst. 100(17): 1260-2, 2008. [ Journal Article ]