Breadcrumb

Laura S. Schmidt, Ph.D.

Laura S. Schmidt, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Urologic Oncology Branch

RESEARCH SUMMARY

Dr. Schmidt's research focuses on the identification of renal cancer susceptibility genes through study of families with inherited renal carcinoma. She contributed as a member of NCI research teams to the cloning of the von Hippel Lindau (VHL) tumor suppressor gene, identification of germline MET mutations in patients with hereditary papillary renal carcinoma, and discovery of germline mutations in a novel tumor suppressor, FLCN, that predispose to Birt-Hogg-Dubé syndrome. Her current research includes FLCN functional studies, and development of mouse models of renal cancer. Dr. Schmidt is participating in recruitment of additional renal cancer families to facilitate the identification of novel renal cancer-causing genes through next-generation sequencing and genomics approaches .

Areas of Expertise

1) inherited renal cancer syndromes, 2) animal models of human cancer, 3) Birt-Hogg-Dubé syndrome, 4) cancer genetics, 5) kidney cancer

Publications

Selected Key Publications

Comprehensive molecular characterization of clear cell renal cell carcinoma

Cancer Genome Atlas Research Network
Nature. 499: 43-9, 2013. [ Journal Article ]

A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma

Farley MN, Schmidt LS, Mester JL, Peña-Llopis S, Pavia-Jimenez A, Christie A, Vocke CD, Ricketts CJ, Peterson J, Middelton L, Kinch L, Grishin N, Merino MJ, Metwalli AR, Xing C, Xie XJ, Dahia PL, Eng C, Linehan WM, Brugarolas J.
Mol. Cancer Res. 11: 1061-71, 2013. [ Journal Article ]

The genetic basis of kidney cancer: a metabolic disease

Linehan WM, Srinivasan R, Schmidt LS.
Nat Rev Urol. 7: 277-85, 2010. [ Journal Article ]

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

Nickerson ML, Warren MB, Toro JR, Matrosova V, Glenn G, Turner ML, Duray P, Merino M, Choyke P, Pavlovich CP, Sharma N, Walter M, Munroe D, Hill R, Maher E, Greenberg C, Lerman MI, Linehan WM, Zbar B, Schmidt LS.
Cancer Cell. 2: 157-64, 2002. [ Journal Article ]

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Schmidt L, Duh FM, Chen F, Kishida T, Glenn G, Choyke P, Scherer SW, Zhuang Z, Lubensky I, Dean M, Allikmets R, Chidambaram A, Bergerheim UR, Feltis JT, Casadevall C, Zamarron A, Bernues M, Richard S, Lips CJ, Walther MM, Tsui LC, Geil L, Orcutt ML, Stackhouse T, Lipan J, Slife L, Brauch H, Decker J, Niehans G, Hughson MD, Moch H, Storkel S, Lerman MI, Linehan WM, Zbar B.
Nat Genet. 16: 68-73, 1997. [ Journal Article ]

Team

Animal Technician (Contr.)
Amy James, B.S.
Animal Technician (Contr.)
Nicole Morris, M.S.