Mark W. Ball, M.D.

Mark W. Ball, M.D.
Assistant Research Physician
Associate Director, Urologic Oncology Fellowship

Team Member of:

Dr. Mark Ball is an attending surgeon in the Urologic Oncology Branch of the National Cancer Institute. He also serves as the Associate Program Director of the Urologic Oncology Fellowship Program. He specializes in the surgical treatment of kidney and adrenal tumors and performs robotic, laparoscopic and open surgery. He has particular expertise in robotic partial nephrectomy and robotic partial adrenlectomy for hereditary cancers syndromes, and has removed over 600 kidney tumors during partial nephrectomy procedures. He is experienced in reoperative surgery in patients with a history of prior surgeries and in patients with multiple tumors. 

Areas of Expertise

1) urologic oncologic surgery, 2) renal cell carcinoma, 3) hereditary kidney cancer syndromes, 4) adrenal surgery, 5) cancer genetics

Contact Info

Mark W. Ball, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 2-5942
Bethesda, MD 20892
Ph: 240-858-3700

Dr. Ball's research focuses on how tumor genetics translates into clinical behavior. He has authored over 100 peer-reviewed manuscripts, multiple book chapters and regularly presents his work at national and international meetings. He was recently a member of an international guideline committee on laparoscopic and robotic adrenal surgery.

He is currently investigating how genetic alterations influence the biology of kidney cancer, including growth and metastasis. Recent work has also focused on the role of somatic mutations in the response to checkpoint blockade in renal cell carcinoma and how genomic features correlate with pathologic features across all urologic malignancies. He also studies the role of preoperative imaging and biopsy in risk stratification prior to surgery.

NIH Scientific Focus Areas:
Cancer Biology, Clinical Research, Genetics and Genomics, Immunology
  1. Ball MW, An JY1 Gomella PT, Gautam R, Ricketts CJ, Vocke CD, Schmidt LS, Merino MJ, Srinivasan R, Malayeri AA, Metwalli AR, Linehan WM
    J Clin Oncol. 2020. [ Journal Article ]
  2. Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, Horak C, Wind-Rotolo M, Tracy A, Giannakis M, Hodi FS, Drake CG, Ball MW, Allaf ME, Snyder A, Hellmann MD, Ho T, Motzer RJ, Signoretti S, Kaelin WG Jr, Choueiri TK, Van Allen EM.
    Science. [Epub ahead of print], 2018. [ Journal Article ]
  3. Ball MW, Srinivasan R.
    Nat Rev Urol. [Epub ahead of print], 2018. [ Journal Article ]
  4. Ball MW
    Discov Med. 23(129): 379-387, 2017. [ Journal Article ]
  5. Ball MW, Gorin MA, Drake CG, Hammers HJ, Allaf ME.
    Eur Urol Focus. [Epub ahead of print], 2017. [ Journal Article ]

Dr. Ball is a fellowship-trained urologic oncologic surgeon. He received his undergraduate degree in biochemistry and molecular biology from Centre College, graduating magna cum laude and Phi Beta Kappa. He received his M.D. from the Johns Hopkins University School of Medicine. He completed his internship and residency at the James Buchanan Brady Urological Institute at Johns Hopkins. He subsequently completed a Society of Urologic Oncology-accredited fellowship at the National Cancer Institute where he worked in the laboratory of W. Marston Linehan, M.D. He is board-certified by the American Board of Urology

Dr. Ball has been the recipient of several academic honors including election to the Alpha Omega Alpha honor society, outstanding laparoscopic surgeon from the Society of Laparoendoscopic Surgery, outstanding research from the Society of Urologic Oncology, recipient of a competitive LRP award from the NIH, and multiple teaching awards.


Sierra's Comeback

April 17, 2019
Friends at NIH

Sierra smiled – and shed a few tears — as she posed recently with her physician, Dr. Mark Ball. After a round of tests and a sleepless night, she’d gotten the good news that she’s cancer free. Read more...

Sierra and Dr. Mark Ball