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Cathy D. Vocke, Ph.D.

Cathy D. Vocke, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Urologic Oncology Branch

RESEARCH SUMMARY

Dr. Vocke’s focus is the genetics of hereditary kidney cancer syndromes. She is involved with discovery and characterization of germline and somatic alterations in genes associated with kidney cancer, including next-gen and whole genome approaches as well as direct sequencing. Dr. Vocke also heads the UOB Tissue Processing and Sequencing Facility, overseeing procurement, preservation, storage, and annotation of all biospecimens, including blood and surgical tissues, obtained from UOB patients. These biospecimens provide an essential resource for many UOB research projects.

Areas of Expertise

1) genetics, 2) kidney cancer, 3) hereditary cancer syndromes, 4) genomics,
5) molecular profiling

Publications

Selected Publications

Germline Mutation in a Family With Mixed Epithelial and Stromal Tumors

Vocke CD, Ricketts CJ, Ball MW, Schmidt LS, Metwalli AR, Middelton LA, Killian JK, Khan J, Meltzer PS, Simonds WF, Merino MJ, Linehan WM
Urology. 2018. [ Journal Article ]

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG
Cell Rep.. 23(12): 3698, 2018. [ Journal Article ]

Comprehensive genomic and phenotypic characterization of germline FH deletion in hereditary leiomyomatosis and renal cell carcinoma

Vocke CD, Ricketts CJ, Merino MJ, Srinivasan R, Metwalli AR, Middelton LA, Peterson J, Yang Y, Linehan WM
Genes Chromosomes Cancer. 56(6): 484-492, 2017. [ Journal Article ]

Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer

Ricketts CJ, Shuch B, Vocke CD, Metwalli AR, Bratslavsky G, Middelton L, Yang Y, Wei MH, Pautler SE, Peterson J, Stolle CA, Zbar B, Merino MJ, Schmidt LS, Pinto PA, Srinivasan R, Pacak K, Linehan WM.
J. Urol. 188: 2063-71, 2012. [ Journal Article ]

High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors

Vocke CD, Yang Y, Pavlovich CP, Schmidt LS, Nickerson ML, Torres-Cabala CA, Merino MJ, Walther MM, Zbar B, Linehan WM.
J. Natl. Cancer Inst. 97: 931-5, 2005. [ Journal Article ]

Team

Animal Technician (Contr)
Catherine Wells
Research Biologist
Robert A. Worrell, Ph.D.
Senior Technical Laboratory Manager
Youfeng Yang, M.S.