Recent Publications

View a listing of our most recent publications.                                                                                                       

Members of the HIV DRP standing outside for a photo, Spring 2023

                      The HIV Dynamics and Replication Program - April, 2023

The HIV Dynamics and Replication Program (HIV DRP) was formed in 1997 as the HIV Drug Resistance Program, with the mission of conducting and fostering multidisciplinary basic, translational, and clinical research focused on problems related to drug-resistant HIV. 

The scope of research conducted by HIV DRP scientists has expanded over the years to encompass a broader range of important problems in virus biology.  Thus, in 2015, the name of the Program was changed to HIV Dynamics and Replication to better capture the breadth of the research carried out by the Program.

Drs. Nikolaitchik, Hu and Chen

About Our Program

Learn about our mission, research interests and goals, and organization.

Clinical Trials

The clinical arm of the HIV Dynamics and Replication Program is under the direction of Frank Maldarelli, M.D., Ph.D. (Clinical Retrovirology Section).  Its primary research focus is to understand the population genetics, evolution, dynamics, and persistence of HIV infection in patients, particularly as related to the development of resistance and possible ways to overcome it.  In collaboration with the National Institute of Allergy and Infectious Diseases/Clinical Center Medicine Department AIDS Clinic and the HIV and AIDS Malignancy Branch of the NCI Center for Cancer Research (CCR), Dr. Maldarelli develops and secures Institutional Review Board approval for clinical trials, and implements them using the support of these groups.  

All CCR clinical trials take place at the NIH Clinical Center in Bethesda, Maryland, and are open to patients with HIV, cancer, or immunodeficiency disorders, regardless of where they live in the United States.

View Trials

For further information about our clinical trials, please contact Dr. Maldarelli at

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - HIV replication, retroviral RNA packaging Ph.D. or equivalent, M.D. or equivalent Wei-Shau Hu, B.V.M., Ph.D.



13th Annual David Derse Memorial Lecture and Award: Carol Carter - October 8. 2024

The HIV Dynamics and Replication Program (HIV DRP) with support from Hye Kyung Chung-Derse and NCI will host the Annual David Derse Memorial Lecture and Award to honor Dr. David Derse’s outstanding research accomplishments and to stimulate the exchange of innovative ideas that he was well known for promoting throughout his scientific career. We are planning this as a hybrid in-person/virtual event.

Carol Carter, Ph.D. (SUNY Distinguished Professor of Microbiology & Immunology, Stony Brook University) will deliver the 13th lecture on October 8. 2024  titled "HOST-TARGETED THERAPEUTICS:  Prazoles Target Tsg101 Ubiquitin E2 Variant Mimicry". 

Please register at:

Registration is free but is required so we can track participation and notify participants of any changes. Additional details, a link to join the meeting remotely will be sent out soon.  

If you have any questions, please contact  

We hope to see you on October 8.

Flyer for the 13th Derse Lecture 2024


HIV DRP Conference Honoring Alan Rein's Career - November 1. 2024

After many years at the National Cancer Institute, Dr. Alan Rein, one of the founding members of the HIV Dynamics and Replication Program (HIV DRP), is retiring in January 2025.  The HIV DRP is organizing a one-day symposium on November 1, 2024, to celebrate Alan’s distinguished career.  We are planning this as a hybrid in-person/virtual event.

The scientific component of the symposium will be provided by the following invited speakers: Françoise Barré-Sinoussi, John Coffin, Mauricio Comas-Garcia, Steve Goff, Nancy Hopkins, Steve Hughes, Delphine Muriaux, Karin Musier-Forsyth, Jonathan Stoye, and Peter Vogt.

We hope that you’ll consider attending to help us celebrate Alan’s remarkable career.  

Please register attendance at:

Additional details, a link to join the meeting remotely will be sent out soon.  Registration is free but is required so we can track participation and notify participants of any changes. 

If you have any questions, please contact  

We hope to see you on November 1.  

HIV DRP Conference - Alan Rein Symposium 2024

HIV DRP 27th Think Tank 2024

The HIV Dynamics and Replication Program (HIV DRP) held it's 27th Annual DRP Think Tank Meeting  on Tuesday, April 30, 2024.  As before, the program consisted of a series of short (15-minutes or less) presentations by members of the local retrovirology community on topics related to HIV, AIDS, and retrovirus biology.   

We had a fantastic turnout with an average of 70 in-person and 100 online.

Congratulations to the winners of the NCI travel fellows award*:

  1. Alex Kleinpeter (HIV-DRP, Eric Freed lab) for his talk on “Recent advances in our understanding of the role of IP6 in HIV-1 replication
  2. Kate Skorupkta (CIL) for her talk on “Structural basis of Vif-induced ubiquitination of APOBEC3H”

*only NCI fellows were eligible for this award.

The event was recorded. Below you will find a zoom link and passcode. Please note this only includes those who agreed to having their talk recorded.

Passcode: 02Pl%wy8

We hope to see you next year!

Members of the Think Tank 2024 enjoying themselves

Think Tank 2024 - Celebrating John Coffin's birthday

News Archive

For more HIV DRP news, see our news archive.  



Training Opportunities

The HIV Dynamics and Replication Program (HIV DRP) is committed to training and supporting the next generation of researchers. There are opportunities available to you at each level of your education/career stage:

  • High School/College Student & Graduate 

  • Medical School Graduate
  • Postdoctoral Fellow

There are summer internships, fellowships, and unique training programs designed to increase expertise in areas such as biotechnology and regulatory review. In addition, NCI has also established several programs to encourage students from populations that are underrepresented in science or individuals from disadvantaged backgrounds who are interested in biomedical research careers. Visit Training Opportunities at NCI CCR to learn more about all the programs that are available. For information on the benefits and support available to trainees, visit Why Choose CCR? 

DRP Advisory Committee (DRPAC)

We have established the DRP Advisory Committee (DRPAC) to provide a voice for our fellows, students and staff to help inform decisions made with DRP management that affect training and career development.

The DRPAC is made up of representatives from each of the DRP labs and works with the Director and PIs to ensure a safe, equitable and inclusive workplace for all program members. DRPAC subcommittees help integrate new hires, facilitate external and internal communications and organize professional and social events, seminars and conferences.

This is a photo of the CCR HIV DRP Advisory Committee standing outside their building, winter 20204
Left to right: Chenglei Li, Shadab Parvez, Manesh Agarwal, Alex Kleinpeter, Hana Veler, Rokeya Siddiqui, Jonathan Kitzrow, Feng Li
DRPAC — Winter 2024