picture of Scarlett Shi

Guoli (Scarlett) Shi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Scarlett earned her Ph.D. in Biochemistry and Molecular Biology from the Chinese Academy of Sciences, under the mentorship of Dr. George F. Gao and Dr. Yoshihiro Kitamura. During that period she studied the molecular basis for Hepatitis C Virus (HCV) replication and the antiviral mechanisms of interferon-stimulated genes. Subsequently, she performed postdoctoral work with Dr. Tetsuro Suzuki in Japan, where she focused on mechanisms of HCV genome incorporation and particle assembly. In 2017, she joined the Compton Lab and currently holds the position of Research Fellow. Scarlett studies how pathways involved in cellular homeostasis influence cell-intrinsic immunity to virus infection.

Areas of Expertise

1) IFITM 2) interferon 3) mTOR 4) SARS-CoV-2 5) COVID


Selected Key Publications

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

Shi G, Chiramel AI, Li T, Lai KK, Kenney AD, Zani A, Eddy AC, Majdoul S, Zhang L, Dempsey T, Beare PA, Kar S, Yewdell JW, Best SM, Yount JS, Compton AA
J Clini Invest. 2022.
Full-Text Article
[ Journal Article ]

Opposing activities of IFITM proteins in SARS-CoV-2 infection

Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS.
EMBO J. 40(3): e106501, 2021.
Full-Text Article
[ Journal Article ]

mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3

Shi G, Ozog S, Torbett BE, Compton AA.
Proc Natl Acad Sci U S A. 115(43): E10069-E10078, 2018.
Full-Text Article
[ Journal Article ]

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins

Shi G, Schwartz O, Compton AA.
Retrovirology. 14(1): 53, 2017.
Full-Text Article
[ Journal Article ]

IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag

Ahi YS, Yimer D, Shi G, Majdoul S, Rahman K, Rein A, Compton AA.
mBio. 11(1): e03088-19, 2020.
Full-Text Article
[ Journal Article ]