Alex Compton, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 535, Room 307
- Frederick, MD 21702-1201
Work in the Antiviral Immunity and Resistance Section, led by Alex Compton, Ph.D., is guided by integrative approaches combining experimental virology, cell biology, and evolutionary biology to reveal dynamic host-virus interactions important for public health. A focus is placed on mechanisms of host protection mediated by the cell-intrinsic innate immune response, as well as the strategies employed by HIV and emerging viruses to evade or overcome these immune barriers.
Areas of Expertise
Improving Human Antiviral Immunity, One Cell at a Time
The clinical outcome of viral infection, the difference between survival and death of the host, rests delicately on events occurring at the molecular level of individual cells. The "cell-intrinsic" arm of innate immunity prevents virus replication in host cells by detecting virus invasion and interfering with the viral life cycle. As such, cell-intrinsic immune factors, also known as host restriction factors, impose the earliest-acting barriers to invading pathogens. Research in this field, which relies increasingly on interdisciplinary approaches and bioinformatics, has demonstrated that the survival of single cells equates strongly with survival of the organism, and even of the population (or species) to which it belongs. Since its inception in 2017, the Compton lab focuses on mechanisms of cell-intrinsic immunity and the strategies employed by HIV and emerging viruses to evade or overcome these immune barriers.
By combining relevant experimental systems in virology with perspectives in cell biology and evolutionary biology, we aim to better understand the factors governing virus entry into cells. We employ a “cross-species” approach, in which diverse viruses are paired with host cells of diverse species in order to reveal cell-intrinsic barriers that limit virus infection. Cellular membranes, composed of proteins and lipids, are the first line of defense against infection. Residents of this critical threshold include cellular transmembrane proteins that remodel membrane vesicles or redirect their trafficking in order to inhibit the viral entry process. In addition to protecting cells from infection, cellular membrane components also impact the structure and infectivity of nascent virions produced from infected cells. Overall, cell-intrinsic immunity acting on membranes performs dual antiviral functions by 1) preventing virus infection of individual cells, and 2) limiting the spread of virus between cells.
Current projects in the lab revolve around the following themes:
1. Mechanisms of virus entry into cells and evasion of cell-intrinsic immunity
2. Enhancement of virus delivery for gene editing in human cells and in vivo
3. Signals regulating the intrinsic antiviral state: stress, metabolism, differentiation, and activation
Alex Compton, Ph.D.
Dr. Alex Compton received his Ph.D. in Molecular and Cellular Biology from the University of Washington in 2012. As a doctoral student in the laboratory of Dr. Michael Emerman (Fred Hutchinson Cancer Research Center), he received an NSF Graduate Research Fellowship and characterized the coevolution of primate lentiviruses with their hosts. Later, Dr. Compton was the recipient of a competitive postdoctoral fellowship from the Louis Pasteur Foundation to support his work at Institut Pasteur in Paris, France. In the lab of Dr. Olivier Schwartz, he provided important insight into the complex ways in which mammalian cells have evolved to block virus entry into cells. In 2017, Dr. Compton joined the HIV Dynamics and Replication Program as Head of the Antiviral Immunity and Resistance Section. His recent awards include a Collaborative Project Award from the National Interagency Confederation for Biomedical Research (2018) and an NIH Intramural Targeted Anti-COVID-19 Program Award (2020). He is currently on the Editorial Board of Viruses, Frontiers in Virology, and Review Commons and was appointed as Guest Editor for the Journal of Molecular Biology Special Issue on "Antiviral Innate Immunity." Dr. Compton currently serves as an Adjunct Instructor in the Department of Biology at Hood College, as a member of the COVID-19 Scientific Interest Group Steering Committee, and as a CCR Tenure Track Investigator Representative.
Interested in joining the Compton lab?
Postdoctoral fellows, graduate students (Ph.D., M.D./Ph.D.), postbaccalaureate fellows, and summer interns (high school, undergraduate) have been trained in the Compton lab since it opened in 2017. Interested candidates should send a CV and statement of interest to firstname.lastname@example.org.
What does the lab have to offer?
- Stable funding and multi-year appointments
- Resource-rich training environment
- Fun, culturally diverse, and interdisciplinary lab mates and department colleagues
- Exciting research spanning from basic to translational, from in vitro to in vivo
- Infinite opportunities for collaboration on a one-of-a-kind campus: the NIH Intramural Research Program is the world’s largest biomedical research institution, with 1,200 principal investigators and over 4,000 postdoctoral fellows conducting basic, translational, and clinical research