HIV Dynamics and Replication Program
About Our Program
The HIV Dynamics and Replication Program (HIV DRP) was formed in 1997 as the HIV Drug Resistance Program, with the mission of conducting and fostering multidisciplinary basic, translational, and clinical research focused on problems related to drug-resistant HIV.
The scope of research conducted by HIV DRP scientists has expanded over the years to encompass a broader range of important problems in virus biology. Thus, in 2015, the name of the Program was changed to HIV Dynamics and Replication to better capture the breadth of the research carried out by the Program. Read more...
Recent Publications
- CryoET structures of immature HIV Gag reveal six-helix bundle
- Early emergence and long-term persistence of HIV-infected T-cell clones in children
- Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy
- Across the hall from pioneers (Perspective article in the Special Issue "In Memory of Stephen Oroszlan")
- Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity
- Mechanism of viral glycoprotein targeting by membrane-associated RING-CH proteins
- HIV-1 integrase inhibitors with modifications that affect their potencies against drug resistant integrase mutants
- A stable immature lattice packages IP6 for HIV capsid maturation
- HIV-1 cores retain their integrity until minutes before uncoating in the nucleus
- CD225 proteins: A family portrait of fusion regulators
- Integrase strand transfer inhibitors are effective anti-HIV drugs
- Development of a cell-based luciferase complementation assay for identification of SARS-CoV-2 3CLpro inhibitors
- Efficient HIV-1 in vitro reverse transcription: optimal capsid stability is required
- Mechanistic analysis of the broad antiretroviral resistance conferred by HIV-1 envelope glycoprotein mutations
- Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1
- Structure-based non-nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants
- Specific guanosines in the HIV-2 leader RNA are essential for efficient viral genome packaging
Archived HIV DRP Seminar
Zheng-Li Shi (Professor, Wuhan Institute of Virology, Chinese Academy of Sciences) presented "From SARS, MERS, to COVID-19, Understanding of the Interspecies Transmission of Bat Coronaviruses" as part of the HIV DRP Seminar Series on April 27, 2021. To view the archived slides of Dr. Shi's presentation, click here.