National Cancer Institute - Cancer.gov

HIV Dynamics and Replication Program

Recent Publications

View a listing of our most recent publications.                                                                                                       

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Members of the HIV DRP standing outside for a photo, Spring 2023

                      The HIV Dynamics and Replication Program - April, 2023

The HIV Dynamics and Replication Program (HIV DRP) was formed in 1997 as the HIV Drug Resistance Program, with the mission of conducting and fostering multidisciplinary basic, translational, and clinical research focused on problems related to drug-resistant HIV. 

The scope of research conducted by HIV DRP scientists has expanded over the years to encompass a broader range of important problems in virus biology.  Thus, in 2015, the name of the Program was changed to HIV Dynamics and Replication to better capture the breadth of the research carried out by the Program.

Drs. Nikolaitchik, Hu and Chen

About Our Program

Learn about our mission, research interests and goals, and organization.

Mission
Research Interests and Goals
Organization
Publications
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Clinical Trials

The clinical arm of the HIV Dynamics and Replication Program is under the direction of Frank Maldarelli, M.D., Ph.D. (Clinical Retrovirology Section).  Its primary research focus is to understand the population genetics, evolution, dynamics, and persistence of HIV infection in patients, particularly as related to the development of resistance and possible ways to overcome it.  In collaboration with the National Institute of Allergy and Infectious Diseases/Clinical Center Medicine Department AIDS Clinic and the HIV and AIDS Malignancy Branch of the NCI Center for Cancer Research (CCR), Dr. Maldarelli develops and secures Institutional Review Board approval for clinical trials, and implements them using the support of these groups.  

All CCR clinical trials take place at the NIH Clinical Center in Bethesda, Maryland, and are open to patients with HIV, cancer, or immunodeficiency disorders, regardless of where they live in the United States.

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For further information about our clinical trials, please contact Dr. Maldarelli at fmalli@mail.nih.gov(link sends email).

PI & Key Staff

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Job Vacancies

We have no open positions in our group at this time, please check back later.

To see all available positions at CCR, take a look at our Careers page. You can also subscribe to receive CCR's latest job and training opportunities in your inbox.

News

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Fellowships

Training Opportunities

The HIV Dynamics and Replication Program (HIV DRP) is committed to training and supporting the next generation of researchers. There are opportunities available to you at each level of your education/career stage:

  • High School/College Student & Graduate 

  • Medical School Graduate

  • Postdoctoral Fellow

There are summer internships, fellowships, and unique training programs designed to increase expertise in areas such as biotechnology and regulatory review. In addition, NCI has also established several programs to encourage students from populations that are underrepresented in science or individuals from disadvantaged backgrounds who are interested in biomedical research careers. Visit Training Opportunities at NCI CCR to learn more about all the programs that are available. For information on the benefits and support available to trainees, visit Why Choose CCR? 

DRP Advisory Committee (DRPAC)

We have established the DRP Advisory Committee (DRPAC) to provide a voice for our fellows, students and staff to help inform decisions made with DRP management that affect training and career development. 

The DRPAC is made up of representatives from each of the DRP labs. DRPAC subcommittees help integrate new hires, facilitate external and internal communications and organize professional and social events, seminars and conferences.

Congratulations to the DRPAC who received a 2024 NCI Director's Award for Workplace Wellness-NCI Champions for their accomplishments, "For launching fellow-led initiatives to enhance the personal and professional development of all HIV Dynamics and Replication Program fellows, students and staff".

This is a photo of the CCR HIV DRP Advisory Committee standing outside their building, winter 20204
Left to right: Chenglei Li, Shadab Parvez, Manesh Agarwal, Alex Kleinpeter, Hana Veler, Rokeya Siddiqui, Jonathan Kitzrow, Feng Li
DRPAC — Winter 2024