Recent Publications

View a listing of our most recent publications.                                                                                                       

Members of the HIV DRP standing outside for a photo, Spring 2023

                      The HIV Dynamics and Replication Program - April, 2023

The HIV Dynamics and Replication Program (HIV DRP) was formed in 1997 as the HIV Drug Resistance Program, with the mission of conducting and fostering multidisciplinary basic, translational, and clinical research focused on problems related to drug-resistant HIV. 

The scope of research conducted by HIV DRP scientists has expanded over the years to encompass a broader range of important problems in virus biology.  Thus, in 2015, the name of the Program was changed to HIV Dynamics and Replication to better capture the breadth of the research carried out by the Program.

Drs. Nikolaitchik, Hu and Chen

About Our Program

Learn about our mission, research interests and goals, and organization.

Clinical Trials

The clinical arm of the HIV Dynamics and Replication Program is under the direction of Frank Maldarelli, M.D., Ph.D. (Clinical Retrovirology Section).  Its primary research focus is to understand the population genetics, evolution, dynamics, and persistence of HIV infection in patients, particularly as related to the development of resistance and possible ways to overcome it.  In collaboration with the National Institute of Allergy and Infectious Diseases/Clinical Center Medicine Department AIDS Clinic and the HIV and AIDS Malignancy Branch of the NCI Center for Cancer Research (CCR), Dr. Maldarelli develops and secures Institutional Review Board approval for clinical trials, and implements them using the support of these groups.  

All CCR clinical trials take place at the NIH Clinical Center in Bethesda, Maryland, and are open to patients with HIV, cancer, or immunodeficiency disorders, regardless of where they live in the United States.

View Trials

For further information about our clinical trials, please contact Dr. Maldarelli at

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Tumor Viruses, RNA Biology Ph.D. or equivalent, M.D. or equivalent Zhi-Ming Zheng, M.D., Ph.D.
Postdoctoral Fellow - HIV replication, retroviral RNA packaging Ph.D. or equivalent, M.D. or equivalent Wei-Shau Hu, B.V.M., Ph.D.
Postdoctoral Fellow - HIV Assembly, Release and Maturation Ph.D. or equivalent Dr Eric O. Freed



13th Annual David Derse Memorial Lecture and Award: Carol Carter - October 8. 2024

The HIV Dynamics and Replication Program (HIV DRP) with support from Hye Kyung Chung-Derse and NCI will host the Annual David Derse Memorial Lecture and Award to honor Dr. David Derse’s outstanding research accomplishments and to stimulate the exchange of innovative ideas that he was well known for promoting throughout his scientific career. We are planning this as a hybrid in-person/virtual event.

Carol Carter, Ph.D. (SUNY Distinguished Professor of Microbiology & Immunology, Stony Brook University) will deliver the 13th lecture on October 8. 2024  titled "HOST-TARGETED THERAPEUTICS:  Prazoles Target Tsg101 Ubiquitin E2 Variant Mimicry". 

Registration is free but is required so we can track participation and notify participants of any changes. 

We hope to see you on October 8.


The Alan Rein Symposium - November 1. 2024

After many years at the National Cancer Institute, Dr. Alan Rein, one of the founding members of the HIV Dynamics and Replication Program (HIV DRP), is retiring in January 2025.  The HIV DRP is organizing a one-day symposium on November 1, 2024, to celebrate Alan’s distinguished career.  We are planning this as a hybrid in-person/virtual event.

The scientific component of the symposium will be provided by the following invited speakers: Françoise Barré-Sinoussi, John Coffin, Mauricio Comas-Garcia, Steve Goff, Nancy Hopkins, Steve Hughes, Delphine Muriaux, Karin Musier-Forsyth, Jonathan Stoye, and Peter Vogt.

We hope that you’ll consider attending to help us celebrate Alan’s remarkable career.  Additional details, a registration link, and a link to join the meeting remotely will be sent out soon.  Registration is free but is required so we can track participation and notify participants of any changes. 

We hope to see you on November 1.  

Travel Awards, Fall HIV/AIDS & Cancer Virology Think Tank Meeting 2023

The NCI’s 2023 Annual CEHCV Fall Think Tank was held on December 8th 2023 at Bethesda campus.  This one-day event is designed to facilitate the exchange of information about advances in the discovery, development, and delivery of antiviral and immunologic approaches for the prevention and treatment of HIV infection, AIDS-related malignancies, and cancer-associated viruses and encourage collaboration.  Opening remarks were held by Vinay Pathak (DRP) and Cynthia Masision (OSP).  John Schiller (NIH) kicked off this year’s event with his talk “The Surprises in Developing HPV Virus-Like Particles as an HPV Prophylactic Vaccine and a Broad-Spectrum Cancer Therapy”.  Followed by the afternoon session guest speaker Genoveffa Franchini on “Innate and Adaptive Immunity to Prevent SIV/HIV infection”.

Invited speakers from the DRP included, Lulu Yu (Zheng lab), Joshua Gluck (Kearney lab), Yuta Hikichi (Freed lab), Ryan Burdick (Pathak lab), Jonathan Kitzrow (Hu lab), and Annemarie Glassy (Maldarelli lab).  Session chairs included the DRP’s staff scientist’s Alice Duchon (Hu lab) and Abdul Waheed (Freed lab).

Travel awards were presented to Yukta Hikichi (Freed lab) and Ryan Burdick (Pathak lab) for outstanding oral presentations.  In addition, both Linsey Farr (Freed lab) and Binh Nguyen (Freed lab) won travel awards for outstanding poster presentations.

To view this event a videocast is available here.

Members of the DRP at the CEHCV Fall Think Tank 2023

Above: members of the DRP presenting their posters.

News Archive

For more HIV DRP news, see our news archive.  



Training Opportunities

The HIV Dynamics and Replication Program (HIV DRP) is committed to training and supporting the next generation of researchers. There are opportunities available to you at each level of your education/career stage:

  • High School/College Student & Graduate 

  • Medical School Graduate
  • Postdoctoral Fellow

There are summer internships, fellowships, and unique training programs designed to increase expertise in areas such as biotechnology and regulatory review. In addition, NCI has also established several programs to encourage students from populations that are underrepresented in science or individuals from disadvantaged backgrounds who are interested in biomedical research careers. Visit Training Opportunities at NCI CCR to learn more about all the programs that are available. For information on the benefits and support available to trainees, visit Why Choose CCR? 

DRP Advisory Committee (DRPAC)

We have established the DRP Advisory Committee (DRPAC) to provide a voice for our fellows, students and staff to help inform decisions made with DRP management that affect training and career development.

The DRPAC is made up of representatives from each of the DRP labs and works with the Director and PIs to ensure a safe, equitable and inclusive workplace for all program members. DRPAC subcommittees help integrate new hires, facilitate external and internal communications and organize professional and social events, seminars and conferences.

This is a photo of the CCR HIV DRP Advisory Committee standing outside their building, winter 20204
Left to right: Chenglei Li, Shadab Parvez, Manesh Agarwal, Alex Kleinpeter, Hana Veler, Rokeya Siddiqui, Jonathan Kitzrow, Feng Li
DRPAC — Winter 2024