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Zhi-Ming Zheng, M.D., Ph.D.

Zhi-Ming Zheng, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Zheng first identified RNA cis-elements in regulation of alternative RNA splicing in papillomavirus in 1996 and has been studying protein-RNA interactions and their consequences in various infections with tumor viruses, including high-risk human papillomaviruses and Kaposi’s sarcoma-associated herpesvirus. This study aims to understand how RNA splicing and small regulatory RNAs regulate the expression of viral and host genes in viral carcinogenesis. The long-term goal is to develop a series of therapeutic approaches to control viral or cellular gene expression for cancer or AIDS treatments and to identify biomarkers for clinical diagnosis and prognosis.

Areas of Expertise

1) RNA processing 2) RNA-protein interactions 3) regulatory RNAs 4) tumor viruses

Publications

Selected Recent Publications

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, Wang KH, Inagaki T, Chuang F, Davis RR, Tepper CG, Nakano K, Izumiya C, Shimoda M, Nakajima KI, Merleev A, Zheng ZM, Campbell M, Izumiya Y
Cell Reports. 39(6): 110788, 2022.
Full-Text Article
[ Journal Article ]

HPV16 and HPV18 Genome Structure, Expression, and Post-Transcriptional Regulation

Yu L, Majerciak V, Zheng ZM
Int J Mol Sci. 23(9): 4943, 2022.
Full-Text Article
[ Journal Article ]

Linking a nuclear lncRNA to cytoplasmic lysosome integrity and cell death

Liu H, Zheng ZM
Proc Natl Acad Sci U S A. 119: e2123082119, 2022.
Full-Text Article
[ Journal Article ]

Protein-RNA interactome analysis reveals wide association of KSHV ORF57 with host non-coding RNAs and polysomes

Beatriz Alvarado-Hernandez, Yanping Ma, Nishi R Sharma, Vladimir Majerciak, Alexei Lobanov, Maggie Cam, Jun Zhu, Zhi-Ming Zheng
J. Virol.. 96: e0178221, 2022.
Full-Text Article
[ Journal Article ]

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