Vladimir Majerciak, Ph.D.

Vladimir Majerciak, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Majerciak's research focuses on the contribution of virus infection to the development of human cancers with emphasis on the regulation of viral and host expression in transformed cells. In his work, he identified the Kaposi’s sarcoma-associated herpesvirus (KSHV) ORF57 protein as a major regulator of KSHV gene expression and uncovered the molecular mechanism of ORF57 action. He also pioneered the use of next-generation sequencing techniques to perform a comprehensive analysis of the transcriptome of several oncogenic viruses including members of the herpesvirus and papillomavirus families.

Areas of Expertise

RNA Biology
Molecular And Cell Biology
Cancer Biology
Next-generation Sequencing And Transcriptome Analysis


Selected Recent Publications

CRISPR/Cas9-mediated knockout and in situ inversion of the ORF57 gene from all copies of the Kaposi's sarcoma-associated herpesvirus genome in BCBL-1 cells

BeltCappellino A, Majerciak V, Lobanov A, Lack J, Cam M, Zheng ZM. (co-corresponding author)
J Virol. Oct 15;93(21): e00628-19, 2019. [ Journal Article ]

KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182

Sharma NR, Majerciak V, Kruhlak MJ, Yu L, Kang JG, Yang A, Gu S, Fritzler MJ, Zheng ZM. (co-first author)
Nucleic Acids Res. Sep 26;47(17): 9368-9385, 2019. [ Journal Article ]

A genome-wide Epstein-Barr virus polyadenylation map and its antisense RNA to EBNA

Majerciak V, Yang W, Zheng J, Zhu J, Zheng ZM.
J Virol. Jan 4;93(2): e01593-18, 2019. [ Journal Article ]

The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function

Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM, Dong YH, Lan K. (co-first author)
PLoS Pathog. Aug 10;14(8): e1007232, 2018. [ Journal Article ]

The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues

Xue XY, Majerciak V, Uberoi A, Kim BH, Gotte D, Chen X, Cam M, Lambert PF, Zheng ZM. (co-first author)
PLoS Pathog. Nov 27;13(11): e1006715, 2017. [ Journal Article ]