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Alan Rein Photo 2024

Alan Rein, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Retrovirus Assembly Section

RESEARCH SUMMARY

Dr. Rein is a recognized expert in virus assembly, particularly with respect to human and murine retroviruses.  Other research interests include structure-function relationships in viral RNA and cellular defense mechanisms against retroviruses.  As Head of the Retrovirus Assembly Section, he studies molecular mechanisms of retroviral replication and pathogenesis, with the hope that this understanding will lead to new methods of combatting retrovirus-induced disease, including AIDS. 

Areas of Expertise

Retroviruses
Virus Assembly
HIV Replication
Virology

Publications

Selected Key Publications

Restriction of Influenza A Virus by SERINC5.

Lai KK, Munro JB, Shi G, Majdoul S, Compton AA, Rein A.
mBio. 6: e0292322, 2022. [ Journal Article ]

Dissection of specific binding of HIV-1 Gag to the “packaging signal” in viral RNA

Comas-Garcia M, Datta SAK, Baker L, Varma R, Gudla PR, Rein A
eLife. 6: e27055, 2017. [ Journal Article ]

An unusual topological structure of the HIV-1 Rev response element

Fang X, Wang J, O’Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SFJ, Rein A, Wang Y-X.
Cell. 155: 594-605, 2013. [ Journal Article ]

Modulation of HIV-like particle assembly in vitro by inositol phosphates

Campbell S, Fisher RJ, Towler EM, Fox S, Issaq HJ, Wolfe T, Phillips LR, Rein A.
Proc Natl Acad Sci U S A. 98: 10875-10879, 2001. [ Journal Article ]

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: Evidence for specific RNA recognition by a "zinc finger-like" protein sequence

Gorelick RJ, Henderson LE, Hanser JP, Rein A.
Proc Natl Acad Sci U S A. 85: 8420-8424, 1988. [ Journal Article ]

Job Vacancies

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Team

Photo of Peter Kin Kin Lai
Postdoctoral Fellow (Visiting)
Kin Kui (Peter) Lai, Ph.D.
Postdoctoral Fellow (CRTA)
Constance Rink, Ph.D.
POSTBACCALAUREATE FELLOW
Noel Hunter, B.S.

News

Sid Datta and Kin Kui Lai publish in mBio

In collaboration with Vanderbilt University Medical Center, Sid Datta and Kin Kui Lai publish in the journal mBio, showing essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication (2024). 

  • Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication (2024). mBio. 2024. Jul17;15(7):e0115824. PMCID: 38912776.

Sid Datta publishes in ACS Infectious Diseases

In collaboration with A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Sid Datta publishes in the journal ACS Infectious Diseases showing Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant (2024).

  •  Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly. ACS Infect Dis. 2024 Jun 25. doi: 10.1021. PMID: 38917054

Alan Rein at CSHL Retrovirology Meeting 2024

Alan Rein gave an oral presentation at the 2024 Cold Spring Harbor Laboratory Retrovirology Meeting.

Image
Members of the HIV DRP Rein lab at CSHL 2024

Photo of Alan (with others) at CSHL.

NIH Intramural AIDS Research Fellowship

Tomas Kroupa (postdoctoral fellow, 2017-2021) received an Intramural AIDS Research Fellowship (IARF) award in 2020 to support his research project on "Kinetics of Specific and Nonspecific Interactions of HIV-1 Gag with RNA."  Awarded by the Office of AIDS Research, Office of Intramural Research, and Office of Intramural Research & Training in the National Institutes of Health, IARFs include full stipend support to successful candidates who demonstrate outstanding scientific potential through both an imaginative and thoughtful research plan and a well thought out career development plan.

Alumni

Yadvinder Ahi, Ph.D.
2012-2019
Research Biologist
Aamir Akram, M.D.
2012
Summer Student
Amanda Aloia, Ph.D.
2008-2011
Postdoctoral Fellow
Laura Baker, B.S.
2015-2017
Postbaccalaureate Fellow
Banhi Biswas, Ph.D.
2018-2023
Postdoctoral Fellow (Visiting)
Stephen J. Campbell, Ph.D.
1999-2001
Research Fellow
Mauricio Comas-Garcia, Ph.D.
2013-2018
Postdoctoral Fellow
Rachael Crist, Ph.D.
2008-2011
Postdoctoral Fellow
Siddhartha Datta, Ph.D.
2001-2024
Staff Scientist
Audrey Denman, M.S.
2015-2016
Postbaccalaureate Fellow
Anwesha Dey, Ph.D.
2003-2004
Special Volunteer
Fatema Fareh
2012
Summer Student
Suzelle Fiedler, M.S.
2010-2011
Special Volunteer
Valerie Goldschmidt, Ph.D.
2003
Special Volunteer
Janice Guynn, P.A.
2010
Summer Student
Demetria Harvin, B.A.
1999-2024
Research Biologist
Marwan Hawari, B.S.
2017
Summer Student
Bridget Heeney, M.B.A.
2014-2015
Summer Student
Catherine Hibbert, Ph.D.
1999-2005
Postdoctoral Fellow
Sangeeth Kolluri, D.O.
2003
Summer Student
Tomas Kroupa, Ph.D.
2017-2021
Postdoctoral Fellow
Shilpa Kulkarni, Ph.D.
2004-2009
Postdoctoral Fellow
Bowen Lian, B.S.
2016
Summer Student
Tania Lombo-Rodriguez, Ph.D.
2008-2013
Postdoctoral Fellow
Joseph Manzi, B.S.
2016-2017
Postbaccalaureate Fellow
Madison Martin, B.S.
2018
Summer Student
Jane Mirro, M.S.
1999-2015
Research Biologist
Laura Minang, M.S.
2011
Summer Student
Pablo Murcia, D.V.M., Ph.D.
2007
Guest Researcher
Delphine Muriaux, Ph.D.
1999-2003
Research Fellow
Smita Nair, Ph.D.
2010-2013
Postdoctoral Fellow
Jayashree Nandi, Ph.D.
2007-2009
Research Fellow
Ayodeji Obayomi
2013
Summer Student
Ina O'Carroll, Ph.D.
2009-2015
Research Fellow
Masamichi Oshima, Ph.D.
2000-2002
Postdoctoral Fellow
Umar Qadri, M.D.
2008
Summer Student
Edric Ramirez-Valdez, B.Sc.
2015
Summer Student
Samuel J. Rulli, Jr., Ph.D.
2003-2007
Postdoctoral Fellow
Sofia Ryan, B.A.
2014-2015
Summer Student
Silvia Sanchez-Martinez, Ph.D.
2007-2012
Postdoctoral Fellow
Lakew Temeselew, Ph.D.
2004-2008
Postdoctoral Fellow
Yashna Thappeta, B.S.
2014-2016
Postbaccalaureate Fellow
Brigette Wang
2017
Special Volunteer
Diborah Yimer, B.S.
2016-2019
Postbaccalaureate Fellow
Shu Zhang, M.S.
2015-2017
Predoctoral Fellow