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Alan  Rein, Ph.D.

Alan Rein, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Rein is a recognized expert in virus assembly, particularly with respect to human and murine retroviruses.  Other research interests include structure-function relationships in viral RNA and cellular defense mechanisms against retroviruses.  As Head of the Retrovirus Assembly Section, he studies molecular mechanisms of retroviral replication and pathogenesis, with the hope that this understanding will lead to new methods of combatting retrovirus-induced disease, including AIDS. 

Areas of Expertise

1) retroviruses, 2) virus assembly, 3) HIV replication, 4) virology, 5) molecular biology, 6) structural biology

Publications

Selected Key Publications

Efficient support of virus-like particle assembly by the HIV-1 packaging signal

Comas-Garcia M, Kroupa T, Datta SA, Harvin DP, Hu WS, Rein A
eLife. 7: e38438, 2018. [ Journal Article ]

Dissection of specific binding of HIV-1 Gag to the “packaging signal” in viral RNA

Comas-Garcia M, Datta SAK, Baker L, Varma R, Gudla PR, Rein A
eLife. 6: e27055, 2017. [ Journal Article ]

An unusual topological structure of the HIV-1 Rev response element

Fang X, Wang J, O’Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SFJ, Rein A, Wang Y-X.
Cell. 155: 594-605, 2013. [ Journal Article ]

Modulation of HIV-like particle assembly in vitro by inositol phosphates

Campbell S, Fisher RJ, Towler EM, Fox S, Issaq HJ, Wolfe T, Phillips LR, Rein A.
Proc Natl Acad Sci U S A. 98: 10875-10879, 2001. [ Journal Article ]

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: Evidence for specific RNA recognition by a "zinc finger-like" protein sequence

Gorelick RJ, Henderson LE, Hanser JP, Rein A.
Proc Natl Acad Sci U S A. 85: 8420-8424, 1988. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (Visiting)
Banhi Biswas, Ph.D.
Research Biologist
Demetria P. Harvin, B.A.
Postdoctoral Fellow (Visiting)
Kin Kui (Peter) Lai, Ph.D.
Postdoctoral Fellow (CRTA)
Constance Rink, Ph.D.

Alumni

Yadvinder Ahi, Ph.D.
Yadvinder Ahi, Ph.D.
2012-2019
Research Biologist
Aamir Akram, M.D.
Aamir Akram, M.D.
2012
Summer Student
Amanda Aloia, Ph.D.
Amanda Aloia, Ph.D.
2008-2011
Postdoctoral Fellow
Laura Baker, B.S.
Laura Baker, B.S.
2015-2017
Postbaccalaureate Fellow
Stephen J. Campbell, Ph.D.
Stephen J. Campbell, Ph.D.
1999-2001
Research Fellow
Mauricio Comas-Garcia, Ph.D.
Mauricio Comas-Garcia, Ph.D.
2013-2018
Postdoctoral Fellow
Rachael Crist, Ph.D.
Rachael Crist, Ph.D.
2008-2011
Postdoctoral Fellow
Audrey Denman, M.S.
Audrey Denman, M.S.
2015-2016
Postbaccalaureate Fellow
Anwesha Dey, Ph.D.
Anwesha Dey, Ph.D.
2003-2004
Special Volunteer
Fatema Fareh
Fatema Fareh
2012
Summer Student
Suzelle Fiedler, M.S.
Suzelle Fiedler, M.S.
2010-2011
Special Volunteer
Valerie Goldschmidt, Ph.D.
Valerie Goldschmidt, Ph.D.
2003
Special Volunteer
Janice Guynn, P.A.
Janice Guynn, P.A.
2010
Summer Student
Marwan Hawari, B.S.
Marwan Hawari, B.S.
2017
Summer Student
Bridget Heeney, M.B.A.
Bridget Heeney, M.B.A.
2014-2015
Summer Student
Catherine Hibbert, Ph.D.
Catherine Hibbert, Ph.D.
1999-2005
Postdoctoral Fellow
Sangeeth Kolluri, D.O.
Sangeeth Kolluri, D.O.
2003
Summer Student
Tomas Kroupa, Ph.D.
Tomas Kroupa, Ph.D.
2017-2021
Postdoctoral Fellow
Shilpa Kulkarni, Ph.D.
Shilpa Kulkarni, Ph.D.
2004-2009
Postdoctoral Fellow
Bowen Lian, B.S.
Bowen Lian, B.S.
2016
Summer Student
Tania Lombo-Rodriguez, Ph.D.
Tania Lombo-Rodriguez, Ph.D.
2008-2013
Postdoctoral Fellow
Joseph Manzi, B.S.
Joseph Manzi, B.S.
2016-2017
Postbaccalaureate Fellow
Madison Martin, B.S.
Madison Martin, B.S.
2018
Summer Student
Jane Mirro, M.S.
Jane Mirro, M.S.
1999-2015
Research Biologist
Laura Minang, M.S.
Laura Minang, M.S.
2011
Summer Student
Pablo Murcia, D.V.M., Ph.D.
Pablo Murcia, D.V.M., Ph.D.
2007
Guest Researcher
Delphine Muriaux, Ph.D.
Delphine Muriaux, Ph.D.
1999-2003
Research Fellow
Smita Nair, Ph.D.
Smita Nair, Ph.D.
2010-2013
Postdoctoral Fellow
Jayashree Nandi, Ph.D.
Jayashree Nandi, Ph.D.
2007-2009
Research Fellow
Ayodeji Obayomi
Ayodeji Obayomi
2013
Summer Student
Ina O'Carroll, Ph.D.
Ina O'Carroll, Ph.D.
2009-2015
Research Fellow
Masamichi Oshima, Ph.D.
Masamichi Oshima, Ph.D.
2000-2002
Postdoctoral Fellow
Umar Qadri, M.D.
Umar Qadri, M.D.
2008
Summer Student
Edric Ramirez-Valdez, B.Sc.
Edric Ramirez-Valdez, B.Sc.
2015
Summer Student
Samuel J. Rulli, Jr., Ph.D.
Samuel J. Rulli, Jr., Ph.D.
2003-2007
Postdoctoral Fellow
Sofia Ryan, B.A.
Sofia Ryan, B.A.
2014-2015
Summer Student
Silvia Sanchez-Martinez, Ph.D.
Silvia Sanchez-Martinez, Ph.D.
2007-2012
Postdoctoral Fellow
Lakew Temeselew, Ph.D.
Lakew Temeselew, Ph.D.
2004-2008
Postdoctoral Fellow
Yashna Thappeta, B.S.
Yashna Thappeta, B.S.
2014-2016
Postbaccalaureate Fellow
Brigette Wang
Brigette Wang
2017
Special Volunteer
Diborah Yimer, B.S.
Diborah Yimer, B.S.
2016-2019
Postbaccalaureate Fellow
Shu Zhang, M.S.
Shu Zhang, M.S.
2015-2017
Predoctoral Fellow