Abdul A. Waheed, Ph.D.

Abdul A. Waheed, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
HIV Dynamics and Replication Program


Dr. Waheed’s research is focused on understanding the role of host factors in human immunodeficiency virus type 1 (HIV-1) particle assembly and release. Several host factors are involved in late stages of the retroviral replication cycle. Understanding the role that cellular proteins and lipids play in HIV-1 assembly and release could lead to the design of novel drugs that target and disrupt these interactions, resulting in inefficient virus release and a block to virus replication.

Several cellular restriction factors inhibit HIV-1 replication both at early and late stages. To counteract these restriction factors, viruses have evolved antagonistic accessory proteins. We are interested in identifying cellular proteins involved in counteraction of host-restriction factors by viral proteins.

Areas of Expertise

Virus Assembly
Cell Biology
Host Factors
Small-molecule Inhibitors


Selected Key Publications

Neutral sphingomyelinase 2 is required for HIV-1 maturation.

Waheed AA, Zhu Y, Agostino E, Naing L, Hikichi Y, Soheilian F, Yoo SW, Song Y, Zhang P, Slusher BS, Haughey NJ, Freed EO.
Proc Natl Acad Sci U S A. 120: e2219475120, 2023. [ Journal Article ]

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

Yoo SW, Waheed AA, Deme P, Tohumeken S, Rais R, Smith MD, DeMarino C, Calabresi PA, Kashanchi F, Freed EO, Slusher BS, Haughey NJ.
Proc Natl Acad Sci U S A. 120: e2219543120, 2023. [ Journal Article ]

HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease

Waheed AA, Ablan SD, Roser JD, Sowder RC, Schaffner CP, Chertova E, Freed EO.
Proc Natl Acad Sci U S A. 104: 8467-71, 2007. [ Journal Article ]

RGS16 inhibits signalling through the G alpha 13-Rho axis

Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM.
Nat Cell Biol. 5: 1095-103, 2003. [ Journal Article ]

Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts)

Waheed AA, Shimada Y, Heijnen HF, Nakamura M, Inomata M, Hayashi M, Iwashita S, Slot JW, Ohno-Iwashita Y.
Proc Natl Acad Sci U S A. 98: 4926-31, 2001. [ Journal Article ]