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Abdul A. Waheed, Ph.D.

Abdul A. Waheed, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Waheed’s research is focused on understanding the role of host factors in human immunodeficiency virus type 1 (HIV-1) particle assembly and release. Several host factors are involved in late stages of the retroviral replication cycle. Understanding the role that cellular proteins and lipids play in HIV-1 assembly and release could lead to the design of novel drugs that target and disrupt these interactions, resulting in inefficient virus release and a block to virus replication.

Several cellular restriction factors inhibit HIV-1 replication both at early and late stages. To counteract these restriction factors, viruses have evolved antagonistic accessory proteins. We are interested in identifying cellular proteins involved in counteraction of host-restriction factors by viral proteins.

Areas of Expertise

1) virology, 2) retroviruses, 3) virus assembly, 4) cell biology, 5) host factors, 6) small-molecule inhibitors

Publications

Selected Key Publications

The Vpu-interacting protein SGTA regulates expression of a non-glycosylated tetherin species

Waheed AA, MacDonald S, Khan M, Mounts M, Swiderski M, Xu Y, Ye Y, Freed EO.
Sci Rep.. 10: 1038/srep24934, 2016. [ Journal Article ]

HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease

Waheed AA, Ablan SD, Roser JD, Sowder RC, Schaffner CP, Chertova E, Freed EO.
Proc Natl Acad Sci U S A. 104: 8467-71, 2007. [ Journal Article ]

Inhibition of HIV-1 replication by amphotericin B methyl ester: Selection for resistant variants

Waheed AA, Ablan SD, Mankowski MK, Cummins JE, Ptak RG, Schaffner CP, Freed EO.
J Biol Chem. 281: 28699-711, 2006. [ Journal Article ]

RGS16 inhibits signalling through the G alpha 13-Rho axis

Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM.
Nat Cell Biol. 5: 1095-103, 2003. [ Journal Article ]

Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts)

Waheed AA, Shimada Y, Heijnen HF, Nakamura M, Inomata M, Hayashi M, Iwashita S, Slot JW, Ohno-Iwashita Y.
Proc Natl Acad Sci U S A. 98: 4926-31, 2001. [ Journal Article ]