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Frank  Maldarelli, M.D., Ph.D.

Frank Maldarelli, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Maldarelli heads the Clinical Retrovirology Section, which develops and implements clinical protocols to elucidate mechanisms underlying the emergence of HIV drug resistance in vivo, the dynamics of infection under treatment, and the role of resistance mutations in the efficacy and failure of subsequent treatments.  Representing the clinical research arm of the HIV Dynamics and Replication Program (HIV DRP), Dr. Maldarelli is an Attending Physician in the NIH NIAID/CCMD HIV Clinic and has established extensive collaborations between the HIV DRP in Frederick and both the NCI HIV and AIDS Malignancy Branch and the NIAID HIV clinical research program in Bethesda.

Areas of Expertise

Clinical Research
HIV Drug Resistance
Antiretroviral Therapy

Publications

Selected Key Publications

Dynamic shifts in the HIV proviral landscape during long term combination antiretroviral therapy: Implications for persistence and control of HIV infections

Anderson EM, Simonetti FR, Gorelick RJ, Hill S, Gouzoulis MA, Bell J, Rehm C, Pérez L, Boritz E, Wu X, Wells D, Hughes SH, Rao V, Coffin JM, Kearney MF, Maldarelli F
Viruses. 12: 136, 2020. [ Journal Article ]

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Patro SC, Brandt LD, Bale MJ, Halvas EK, Joseph KW, Shao W, Wu X, Guo S, Murrell B, Wiegand A, Spindler J, Raley C, Hautman C, Sobolewski M, Fennessey CM, Hu WS, Luke B, Hasson JM, Niyongabo A, Capoferri AA, Keele BF, Milush J, Hoh R, Deeks SG, Maldarelli F, Hughes SH, Coffin JM, Rausch JW, Mellors JW, Kearney MF
Proc Natl Acad Sci U S A. 116(51): 25891-99, 2019. [ Journal Article ]

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication

Bozzi G, Simonetti FR, Watters SA, Anderson EM, Gouzoulis M, Kearney MF, Rote P, Lange C, Shao W, Gorelick R, Fullmer B, Kumar S, Wank S, Hewitt S, Kleiner DE, Hattori J, Bale MJ, Hill S, Bell J, Rehm C, Grossman Z, Yarchoan R, Uldrick T, Maldarelli F
Sci Adv. 5(9): eaav2045, 2019. [ Journal Article ]

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F
Proc. Natl. Acad. Sci. USA. 113: 1883-8, 2016. [ Journal Article ]

HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, Spindler J, Ferris AL, Mellors JW, Kearney MF, Coffin JM, Hughes SH
Science. 345: 179-83, 2014. [ Journal Article ]

Job Vacancies

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Team

Photo of Adam
Special Volunteer
Matthew Adan, M.D
Advanced Practice Nurse
Jessica Earhart, M.S.N.L.M., B.S.
Special Volunteer
Kristi Huik, Ph.D.
Postbaccalaureate Fellow (CRTA)
Ariana Savramis, B.A.
Postdoctoral Fellow (Visiting)
Thuy Nguyen, Ph.D.
Summer student
Phuong Pham, B.S.
Staff Scientist
Guanhan Li, Ph.D.
Photo of Annie
Postbacccalaureate Fellow
Annemarie Glassey, B.S.
Postbaccalaureate Fellow
Danielle Konlian, B.S.
Research Fellow
Feng Li, Ph.D.
Special Volunteer
Long Li
Postbaccalaureate Fellow
Dorcas Nalisi, B.S.

News

Travel Award, Fall HIV/AIDS & Cancer Virology Think Tank Meeting

Chuen-Yen Lau won a $1000 travel award for her outstanding talk at the 2022 Fall HIV/AIDS & Cancer Virology Think Tank Meeting.  This annual Think Tank meeting on the NIH-Bethesda campus provides a venue for students, postdoctoral fellows, and staff scientists to present emerging work and hypotheses in the field of cancer virology.  The Think Tank travel awards are provided by the Center of Excellence in HIV/AIDS & Cancer Virology, Center for Cancer Research, NCI.

Previous winnner from the Maldarelli lab include: Paula Rote (2017)

    New Investigator Scholarships, Conference on Retroviruses and Opportunistic Infections

    Kristi Huik was awarded a New Investigator Scholarship to present her research findings in the 2020 Conference on Retroviruses and Opportunistic Infections (CROI).  CROI scholarship awardees in previous years include Elizabeth Anderson and Camille Lange in 2018 and 2017, Sarah Watters in 2015, and Francesco Simonetti in 2014.

    2019 Presentation Award in Microbiology, Annual Biomedical Research Conference for Minority Students

    Natalie Lindo received a 2019 Presentation Award in Microbiology for presenting her research findings at the Annual Biomedical Research Conference for Minority Students.

    Scholarship Award, International Workshop on HIV Drug Resistance and Treatment Strategies

    Kristi Huik was awarded a scholarship to attend the 2018 International Workshop on HIV Drug Resistance and Treatment Strategies in Johannesburg, South Africa, to give an oral presentation on the latest findings of her research project ("Mechanism of Emergence of Resistance of T97A during Dolutegravir Therapy").

    Young Scientist Sponsorship, 68th Lindau Nobel Laureate Meeting

    Kristi Huik was awarded a full sponsorship by the Estonian Academy of Sciences to participate in the 68th Lindau Nobel Laureate Meeting in June 2018.  She received this award based on her outstanding research on the role of host genetic factors in HIV acquisition, HIV drug resistance, and molecular epidemiology of other infections while she was a Ph.D. student at the University of Tartu before joining the Maldarelli lab.  The annual Lindau Nobel Laureate Meeting is a prestigious gathering of around 30 Nobel Laureates and 500-600 young scientists — including postdoctoral fellows, Ph.D. students, and undergraduates — who convene to communicate leading issues in physiology and medicine in a forum that includes lectures, panel discussions, poster sessions, master classes, Agora talks, and science walks.

      Travel Awards, HIV DRP Think Tank Meeting

      Elizabeth Anderson received a $1000 travel award from the HIV DRP for one of the two best presentations by NCI fellows at the 2018 HIV DRP Think Tank Meeting.  Francesco Simonetti received this Travel Award for his presentation at the 2014 HIV DRP Think Tank Meeting.

        Diversity Career Development Program, NIH

        Camille Lange graduated from the Diversity Career Development Program (DCDP) at NIH in 2016.  DCDP graduates were nominated and selected among a group of talented NIH staff for participation in this program.

          Scholarship Award, 2016 Towards an HIV Cure Symposium and 21st International AIDS Conference (AIDS 2016)

          Elizabeth Anderson was awarded a scholarship to attend the 2016 Towards an HIV Cure Symposium and the 21st International AIDS Conference (AIDS 2016) in Durban, South Africa.  She presented the latest findings of her research project ("Intra-patient, full length analysis of HIV gag genetic variation identifies regions of variability") at both meetings.

            2015 NCI Director's Award

            Image
            Photo of NCI Integration Sites Analysis (ISA) Team 2015

            Members of the NCI HIV Integration Sites Analysis (ISA) team received a group award at the NCI Director's Award ceremony in November 2015 "for discoveries on HIV survival during antiretroviral therapy, revealing the importance of integration site and clonal expansion."  The ISA group award recipients included Stephen Hughes, Andrea Ferris, Shawn Hill, Mary Kearney, Frank Maldarelli, Wei Shao, and Jonathan Spindler (HIV DRP); Francesco Simonetti (University of Milan); John Coffin (Tufts University); John Mellors (University of Pittsburgh); and David Wells, Ling Su, and Xiaolin Wu (Leidos Biomedical Research, Inc.).

            NIH Postbac Poster Day Award

            Tiffany Tanzosh was honored for presenting one of the best posters on NIH Postbac Poster Day in 2012.  Established in 2001, NIH Postbac Poster Day added a judging component in 2011 to highlight the contributions of postbaccalaureate fellows to the NIH Intramural Research Program.  Awardees are recognized for having authored posters that score in the top 20% of all posters presented.

              Alumni

              Lindsey Adams, B.S.
              2020-2022
              Postbaccalaureate Fellow
              Shiva Ambardar
              2012-2013
              Special Volunteer
              Elizabeth Anderson, Ph.D.
              2011-2019
              Postdoctoral Fellow, Postbaccalaureate Fellow
              Himanshu Batra, Ph.D.
              2019-2020
              Special Volunteer
              Jennifer Bell, R.N., B.S., C.C.R.C,
              2014-2020
              Protocol Coordinator
              Giorgio Bozzi, M.D.
              2015-2016
              Infectious Disease Fellow
              Margaret Caplan, M.D.
              2009
              Special Volunteer
              Karoll Cortez, M.D.
              2009-2010
              Staff Clinician
              Francesca Cossarini, M.D.
              2008-2010
              Infectious Disease Fellow
              Kristen Danley, M.D.
              2006
              Summer Student
              Sophie Dean
              2014 and 2015
              Summer Student
              Gabriella Diaz, R.N., B.S.N.
              2012-2014
              Study Coordinator
              Monica Gouzoulis, B.S.
              2018-2019
              Postbaccalaureate Fellow
              Zehava Grossman, Ph.D.
              SCTIENTIST (CONTR)
              Junko Hattori, Ph.D.
              2013-2016
              Research Fellow
              Shawn Hill, M.S., M.B.A.
              1991-2021
              Research Biologist
              Kristen Kent, B.S.
              2019
              Summer Student
              Daniel Kordella, M.S.
              2012-2013
              Postbaccalaureate Fellow
              Laure Kouyoudjian, P.A.C.
              2015-2016
              Physician Assistant
              Nicholas Kovacs, Ph.D.
              2012 and 2013
              Summer Student
              Natalie Lindo, B.S.
              2018-2020
              Postbaccalaureate Fellow
              Camille Lange, Ph.D.
              2015-2020
              Postdoctoral Fellow
              Erin Madeen, Ph.D.
              2019-2023
              Postdoctoral Fellow (Cancer Prevention Fellowship Program)
              Charmaine Peters, M.D.
              2014-2015
              Special Volunteer
              Carrie Poethke, D.O.
              2008-2010
              Postbaccalaureate Fellow
              Paula Rote, M.D.
              2017-2018
              M.D. Student
              Francesco Simonetti, M.D.
              2013-2015
              Infectious Disease Fellow
              Rhoda Smith, R.N.
              2012
              Summer Student
              Tiffany Tanzosh, B.S.
              2010-2012
              Postbaccalaureate Fellow
              James Virga, B.S.
              2000-2022
              Postbaccalaureate Fellow
              Sarah Watters, Ph.D.
              2014-2016
              Predoctoral Fellow
              Eleanor Wilson, M.H.S., M.D.
              2010-2011
              Infectious Disease Fellow
              William Yang
              2021-2022
              Special Volunteer
              Mary-Elizabeth Zipparo, B.S.
              2020-2020
              Postbaccalaureate Fellow