Breadcrumb

Frank  Maldarelli, M.D., Ph.D.

Frank Maldarelli, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Maldarelli heads the Clinical Retrovirology Section, which develops and implements clinical protocols to elucidate mechanisms underlying the emergence of HIV drug resistance in vivo, the dynamics of infection under treatment, and the role of resistance mutations in the efficacy and failure of subsequent treatments.  Representing the clinical research arm of the HIV Dynamics and Replication Program (HIV DRP), Dr. Maldarelli is an Attending Physician in the NIH NIAID/CCMD HIV Clinic and has established extensive collaborations between the HIV DRP in Frederick and both the NCI HIV and AIDS Malignancy Branch and the NIAID HIV clinical research program in Bethesda.

Areas of Expertise

1) clinical research, 2) HIV drug resistance, 3) antiretroviral therapy, 4) computational biology, 5) infectious diseases, 6) virology

Publications

Selected Key Publications

Dynamic shifts in the HIV proviral landscape during long term combination antiretroviral therapy: Implications for persistence and control of HIV infections

Anderson EM, Simonetti FR, Gorelick RJ, Hill S, Gouzoulis MA, Bell J, Rehm C, Pérez L, Boritz E, Wu X, Wells D, Hughes SH, Rao V, Coffin JM, Kearney MF, Maldarelli F
Viruses. 12: 136, 2020. [ Journal Article ]

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Patro SC, Brandt LD, Bale MJ, Halvas EK, Joseph KW, Shao W, Wu X, Guo S, Murrell B, Wiegand A, Spindler J, Raley C, Hautman C, Sobolewski M, Fennessey CM, Hu WS, Luke B, Hasson JM, Niyongabo A, Capoferri AA, Keele BF, Milush J, Hoh R, Deeks SG, Maldarelli F, Hughes SH, Coffin JM, Rausch JW, Mellors JW, Kearney MF
Proc Natl Acad Sci U S A. 116(51): 25891-99, 2019. [ Journal Article ]

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication

Bozzi G, Simonetti FR, Watters SA, Anderson EM, Gouzoulis M, Kearney MF, Rote P, Lange C, Shao W, Gorelick R, Fullmer B, Kumar S, Wank S, Hewitt S, Kleiner DE, Hattori J, Bale MJ, Hill S, Bell J, Rehm C, Grossman Z, Yarchoan R, Uldrick T, Maldarelli F
Sci Adv. 5(9): eaav2045, 2019. [ Journal Article ]

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F
Proc. Natl. Acad. Sci. USA. 113: 1883-8, 2016. [ Journal Article ]

HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Maldarelli F, Wu X, Su L, Simonetti FR, Shao W, Hill S, Spindler J, Ferris AL, Mellors JW, Kearney MF, Coffin JM, Hughes SH
Science. 345: 179-83, 2014. [ Journal Article ]

Job Vacancies

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Team

Postbaccalaureate Fellow (CRTA)
Lindsey Adams, B.S.
Special Volunteer
Matthew Adan, B.S.
Advanced Practice Nurse
Jessica Earhart, M.S.N.L.M., B.S.
Scientist (Contr)
Zehava Grossman, Ph.D.
Special Volunteer
Kristi Huik, Ph.D.
Associate Research Physician
Chuen-Yen Corey Lau, M.D.
Postdoctoral Fellow (Cancer Prevention Fellowship Program)
Erin Madeen, Ph.D.
Postbaccalaureate Fellow (CRTA)
Ariana Savramis, B.A.
Postdoctoral Fellow (Visiting)
Thuy Nguyen, Ph.D.
Postbaccalaureate Fellow (CRTA)
James Virga, B.S.
Special Volunteer
William Yang
Postbaccalaureate Fellow (CRTA)
Mary-Elizabeth Zipparo, B.S.

Alumni

Shiva Ambardar
Shiva Ambardar
2012-2013
Special Volunteer
Elizabeth Anderson, Ph.D.
Elizabeth Anderson, Ph.D.
2011-2019
Postdoctoral Fellow, Postbaccalaureate Fellow
Himanshu Batra, Ph.D.
Himanshu Batra, Ph.D.
2019-2020
Special Volunteer
Jennifer Bell, R.N., B.S., C.C.R.C,
Jennifer Bell, R.N., B.S., C.C.R.C,
2014-2020
Protocol Coordinator
Giorgio Bozzi, M.D.
Giorgio Bozzi, M.D.
2015-2016
Infectious Disease Fellow
Margaret Caplan, M.D.
Margaret Caplan, M.D.
2009
Special Volunteer
Karoll Cortez, M.D.
Karoll Cortez, M.D.
2009-2010
Staff Clinician
Francesca Cossarini, M.D.
Francesca Cossarini, M.D.
2008-2010
Infectious Disease Fellow
Kristen Danley, M.D.
Kristen Danley, M.D.
2006
Summer Student
Sophie Dean
Sophie Dean
2014 and 2015
Summer Student
Gabriella Diaz, R.N., B.S.N.
Gabriella Diaz, R.N., B.S.N.
2012-2014
Study Coordinator
Monica Gouzoulis, B.S.
Monica Gouzoulis, B.S.
2018-2019
Postbaccalaureate Fellow
Junko Hattori, Ph.D.
Junko Hattori, Ph.D.
2013-2016
Research Fellow
Shawn Hill, M.S., M.B.A.
Shawn Hill, M.S., M.B.A.
1991-2021
Research Biologist
Kristen Kent, B.S.
Kristen Kent, B.S.
2019
Summer Student
Daniel Kordella, M.S.
Daniel Kordella, M.S.
2012-2013
Postbaccalaureate Fellow
Laure Kouyoudjian, P.A.C.
Laure Kouyoudjian, P.A.C.
2015-2016
Physician Assistant
Nicholas Kovacs, Ph.D.
Nicholas Kovacs, Ph.D.
2012 and 2013
Summer Student
Natalie Lindo, B.S.
Natalie Lindo, B.S.
2018-2020
Postbaccalaureate Fellow
Camille Lange, Ph.D.
Camille Lange, Ph.D.
2015-2020
Postdoctoral Fellow
Charmaine Peters, M.D.
Charmaine Peters, M.D.
2014-2015
Special Volunteer
Carrie Poethke, D.O.
Carrie Poethke, D.O.
2008-2010
Postbaccalaureate Fellow
Paula Rote, M.D.
Paula Rote, M.D.
2017-2018
M.D. Student
Francesco Simonetti, M.D.
Francesco Simonetti, M.D.
2013-2015
Infectious Disease Fellow
Rhoda Smith, R.N.
Rhoda Smith, R.N.
2012
Summer Student
Tiffany Tanzosh, B.S.
Tiffany Tanzosh, B.S.
2010-2012
Postbaccalaureate Fellow
Sarah Watters, Ph.D.
Sarah Watters, Ph.D.
2014-2016
Predoctoral Fellow
Eleanor Wilson, M.H.S., M.D.
Eleanor Wilson, M.H.S., M.D.
2010-2011
Infectious Disease Fellow