Cancer and Developmental Biology Laboratory

Chief
Ira O. Daar, Ph.D.

The interests of the Cancer and Developmental Biology Laboratory (CDBL) are centered on the analysis of embryonic development, particularly the mechanisms of growth control and the regulation of differentiation through growth factors, cytokines, and their receptors. The study of how embryos grow and develop from the fertilized egg is not only of intrinsic interest but also of relevance to understanding the origins and development of a wide variety of cancers. Many of the cellular processes involved in embryonic development (such as proliferation, adhesion, migration, and differentiation) are mediated by the actions of growth factors and their receptors. In many cancers, these same growth factors and receptors frequently are abnormally expressed or are even mutated to form oncogenes. Understanding the functions of these factors in development will deepen our knowledge of the biology of cancer. 

The Laboratory at present consists of five sections. The Developmental Signal Transduction Section, directed by Dr. Ira Daar, focuses on the mechanism by which Eph receptor tyrosine kinases and their ephrin ligands signal events affecting cell-cell adhesion and morphogenetic movements. The Developmental Biology Unit, headed by Dr. Susan Mackem, focuses on signaling through the hedgehog pathway using limb development/digit formation as a model system. The Genetics of Vertebrate Development, headed by Dr. Mark Lewandoski, is studying the functions of growth factors during development in the outgrowth and patterning of the limb and the anterior/posterior axis during somitogenesis. The Cell Signaling in Vertebrate Development Section, headed by Dr. Terry Yamaguchi, is analyzing the functions of the Wnt family of genes in development and their dysregulation in cancer. The Phospholipid and Sphingolipid Signaling Section, under Dr. Jairaj Acharya, explores the impact of sphingolipid flux in various biological processes, utilizing drosophila and mouse models. Dr. Alan Perantoni, is a scientist emeritus analyzing the functions of inductive cytokines in nephrogenesis and dysregulation of inductive signaling in nephroblastoma/Wilms tumor development. 

Position Keywords Contact Name Contact E-mail Number of Positions
Postdoctoral Fellow - Developmental Biology, Signal transduction

Developmental Biology, Signal transduction

Ira Daar

daari@mail.nih.gov

1
Postdoctoral Fellow - Embryonic Development, FGF Signaling

Embryonic Development, FGF Signaling

Mark Lewandoski

lewandom@mail.nih.gov

1
Postdoctoral Fellow- Morphogenesis, Hedgehog Signaling

Morphogenesis, Hedgehog Signaling

Susan Mackem

mackems@mail.nih.gov

1
Postdoctoral Fellow - Wnt Signaling, Stem Cells

Wnt Signaling, Stem Cells, Developmental Biology

Terry Yamaguchi

yamagute@mail.nih.gov

1

About

The interests of the Cancer and Developmental Biology Laboratory (CDBL) are centered on the analysis of embryonic development, particularly the mechanisms of growth control and the regulation of differentiation through growth factors, cytokines, and their receptors. The study of how embryos grow and develop from the fertilized egg is not only of intrinsic interest but also of relevance to understanding the origins and development of a wide variety of cancers. Many of the cellular processes involved in embryonic development (such as proliferation, adhesion, migration, and differentiation) are mediated by the actions of growth factors and their receptors. In many cancers, these same growth factors and receptors frequently are abnormally expressed or are even mutated to form oncogenes. Understanding the functions of these factors in development will deepen our knowledge of the biology of cancer. 

The Laboratory at present consists of five sections. The Developmental Signal Transduction Section, directed by Dr. Ira Daar, focuses on the mechanism by which Eph receptor tyrosine kinases and their ephrin ligands signal events affecting cell-cell adhesion and morphogenetic movements. The Developmental Biology Unit, headed by Dr. Susan Mackem, focuses on signaling through the hedgehog pathway using limb development/digit formation as a model system. The Genetics of Vertebrate Development, headed by Dr. Mark Lewandoski, is studying the functions of growth factors during development in the outgrowth and patterning of the limb and the anterior/posterior axis during somitogenesis. The Cell Signaling in Vertebrate Development Section, headed by Dr. Terry Yamaguchi, is analyzing the functions of the Wnt family of genes in development and their dysregulation in cancer. The Phospholipid and Sphingolipid Signaling Section, under Dr. Jairaj Acharya, explores the impact of sphingolipid flux in various biological processes, utilizing drosophila and mouse models. Dr. Alan Perantoni, is a scientist emeritus analyzing the functions of inductive cytokines in nephrogenesis and dysregulation of inductive signaling in nephroblastoma/Wilms tumor development. 

PI & Key Staff

Positions

Position Keywords Contact Name Contact E-mail Number of Positions
Postdoctoral Fellow - Developmental Biology, Signal transduction

Developmental Biology, Signal transduction

Ira Daar

daari@mail.nih.gov

1
Postdoctoral Fellow - Embryonic Development, FGF Signaling

Embryonic Development, FGF Signaling

Mark Lewandoski

lewandom@mail.nih.gov

1
Postdoctoral Fellow- Morphogenesis, Hedgehog Signaling

Morphogenesis, Hedgehog Signaling

Susan Mackem

mackems@mail.nih.gov

1
Postdoctoral Fellow - Wnt Signaling, Stem Cells

Wnt Signaling, Stem Cells, Developmental Biology

Terry Yamaguchi

yamagute@mail.nih.gov

1

Contact Info

Cancer and Developmental Biology Laboratory
Center for Cancer Research
National Cancer Institute
Building 539, Room 127B
Frederick, MD 21702-1201
Ph: 301-228-4628
Program Specialist
301-228-4628
Administrative Lab Manager
301-846-1837