Bau-Lin Huang, Ph.D.

Bau-Lin Huang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


“Grow and re-grow” is the main theme of Dr. Huang’s research interest. Morphogenesis has robust mechanisms to ensure the correct appearance and function of tissues/organs. Strikingly, the regenerated tissues/organs in regenerable animals, such as zebrafish, lizards and axolotls, retain original morphology, pattern and size, suggesting that the same mechanisms are re-deployed during the process of regeneration. He uses the embryonic mouse limb as a model to unveil the mechanisms behind the developmental process and is seeking its potential application for future regenerative medicine. Approaches used in this study include pharmacological manipulation of cell signaling in micromass and organ culture, and mouse mutant and reporter line crosses, coupled with confocal imaging and transcriptomic analysis.

Areas of Expertise

Embryonic Development
Limb Morphogenesis And Cartilage/bone Formation
Organ Culture
Mouse Genetics And Genomics
Cell Signaling (eg, Wnt, Bmp And Fgf)


Selected Recent Publications

CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance

Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM.
J Bone Miner Res. 33(6): 1076-1089, 2018. [ Journal Article ]

PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud

Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA.
Development. 143(24): 4608-4619, 2016. [ Journal Article ]

An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5'Hoxd-Gli3 antagonism

Huang BL, Trofka A, Furusawa A, Norrie JL, Rabinowitz AH, Vokes SA, Mark Taketo M, Zakany J, Mackem S.
Nat Commun. 7: 12903, 2016. [ Journal Article ]

Evolutionary developmental biology: Use it or lose it

Huang BL, Mackem S.
Nature. 511(7507): 34-5, 2014. [ Journal Article ]