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Yoo-Seok (Rich) Hwang, Ph.D.

Yoo-Seok (Rich) Hwang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Ephs/ephrins signaling is a usual suspect of metastatic cancer initiation. The normal job of this signaling is to interpret cell-cell contacts, translate them and determine self versus counter-self identity in events like tissue separation, boundary formation and axonal path finding in developing organs. In certain metastatic cancers however, Eph/ephrin signaling is de-regulated -- the normal mechanism of signaling goes awry, orders cells to delaminate from their origin and migrate distances. Dr. Hwang has profound interest in the mechanisms of cell-cell adhesion and migration involving Eph/ephrin signaling. Using Xenopus as a model system he tries to answer to the questions of how Eph/ephrin signaling dictates cellular separation, adhesion and migration.

Areas of Expertise

1) embryology 2) development of amphibia 3) cell differentiation 4) signal transduction 5) cell migration 6) cell-cell adhesion

Publications

Selected Key Publications

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

Lu Q, Insinna C, Ott C, Stauffer J, Pintado PA, Rahajeng J, Baxa U, Walia V, Cuenca A, Hwang YS, Daar IO, Lopes S, Lippincott-Schwartz J, Jackson PK, Caplan S, and Westlake CJ.
Nat Cell Biol. 17(3): 228-40, 2015. [ Journal Article ]

EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation

Cho HJ, Hwang YS, Mood K, Ji YJ, Lim J, Morrison DK, and Daar IO.
J Biol Chem. 289(26): 18556-68, 2014. [ Journal Article ]

Ephrin-B2 is required for apical constriction and is regulated by ADAM-10 and flotillin-1 in Xenopus

Ji YJ, Hwang YS, Soria K, Lee H-S, Winterbottom E, Cho HJ, and Daar IO.
Nat Commun. 5: 3516, 2014. [ Journal Article ]

Abelson interactor 1 (ABI1) and its interaction with Wiskott-Aldrich syndrome protein (wasp) are critical for proper eye formation in Xenopus embryos

Singh A, Emily Winterbottom EF, Ji YJ, Hwang YS, and Daar IO.
J Biol Chem. 288(20): 14135-46, 2013. [ Journal Article ]

The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1

Hwang YS, Lee H-Y, Kamata T, Mood K, Cho HJ, Winterbottom E, Ji YJ, Singh A, and Daar IO.
Genes Dev. 27(5): 491-503, 2013. [ Journal Article ]