Word Cloud for Laboratory of Protein Dynamics and Signaling: proliferation, differentiation, development, embryos, apoptosis, tumorigenesis, metastasis, proteins, pathways, methylation, sumoylation, signaling, regulation, processes, organelles, centrosomes, dynamics, function, ubiquitin, histones.
Chief
Allan M. Weissman, M.D.
Administrative Secretary
Kimberly Mellon

Center for Cancer Research
National Cancer Institute

Building 560, Room 22-103
Frederick, MD 21702-1201
301-846-1356

The Laboratory of Protein Dynamics and Signaling (LPDS) investigates fundamental macromolecular interactions and cellular processes that are important for cell proliferation and differentiation, apoptosis, tumorigenesis and metastasis.

The Loncarek group studies fundamentals of centrosome biology and cellular processes associated with their activity. Centrosomes are malleable organelles whose number, size, function and molecular composition respond to cell cycle dynamics, differentiation status, and cell type. Despite an apparent interplay between the centrosome and cell cycles, very little is known about how the two cycles synchronize. The Loncarek group aims to understand molecular mechanisms that couple the two cycles in normal and pathological conditions, combining biochemical methods with high-end light and electron microscopy.

The Bernal group is interested in the chemical modulation signaling process involved in disease.  Their research focuses on the development of synthetic compounds to probe protein-protein and protein-DNA interactions with an eye towards the development of novel, targeted therapeutics.  

The Weissman group has a primary interest in the function of components of the ubiquitin-proteasome system (UPS) and their cellular roles under normal and pathological conditions including cancer, metastasis and in apoptosis. Areas of focus include structure-function relationships for RING ubiquitin ligases and the role of the ubiquitin system in organelles including the endoplasmic reticulum and mitochondria.

The LPDS is located on the NCI campus at Frederick and has close ties to a number of other laboratories here, as well as to laboratories and branches on the Bethesda campus of NIH. The NCI's Frederick campus offers state-of-the-art facilities and a highly interactive environment for trainees.

About

The Laboratory of Protein Dynamics and Signaling (LPDS) investigates fundamental macromolecular interactions and cellular processes that are important for cell proliferation and differentiation, apoptosis, tumorigenesis and metastasis.

The Loncarek group studies fundamentals of centrosome biology and cellular processes associated with their activity. Centrosomes are malleable organelles whose number, size, function and molecular composition respond to cell cycle dynamics, differentiation status, and cell type. Despite an apparent interplay between the centrosome and cell cycles, very little is known about how the two cycles synchronize. The Loncarek group aims to understand molecular mechanisms that couple the two cycles in normal and pathological conditions, combining biochemical methods with high-end light and electron microscopy.

The Bernal group is interested in the chemical modulation signaling process involved in disease.  Their research focuses on the development of synthetic compounds to probe protein-protein and protein-DNA interactions with an eye towards the development of novel, targeted therapeutics.  

The Weissman group has a primary interest in the function of components of the ubiquitin-proteasome system (UPS) and their cellular roles under normal and pathological conditions including cancer, metastasis and in apoptosis. Areas of focus include structure-function relationships for RING ubiquitin ligases and the role of the ubiquitin system in organelles including the endoplasmic reticulum and mitochondria.

The LPDS is located on the NCI campus at Frederick and has close ties to a number of other laboratories here, as well as to laboratories and branches on the Bethesda campus of NIH. The NCI's Frederick campus offers state-of-the-art facilities and a highly interactive environment for trainees.

Directory