Breadcrumb

Scott K. Durum, Ph.D.

Scott K. Durum, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. Durum's research is aimed at determining the mechanism of action of IL-7, a cytokine that is essential for T cell development and survival. Understanding the IL-7 pathways has given sights into the physiology of lymphocytes, suggested therapeutic strategies for modulating immunity, and revealed mechanisms of leukemogenesis.

Areas of Expertise

1) interleukin-7 (IL-7) 2) immunity 3) leukemogenesis

Publications

Selected Recent Publications

New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK
Leukemia. 34(1): 35-49, 2020. [ Journal Article ]

Flip the coin: IL-7 and IL-7R in health and disease

Barata JT, Durum SK, Seddon B
Nat Immunol. 20(12): 1584-93, 2019. [ Journal Article ]

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Rice CM, Davies LC, Subleski JJ, Maio N, Gonzalez-Cotto M, Andrews C, Patel NL, Palmieri EM, Weiss JM, Lee JM, Annunziata CM, Rouault TA, Durum SK, McVicar DW
Nat Commun.. 9(1): 5099, 2018. [ Journal Article ]

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

Cramer SD, Hixon JA, Andrews C, Porter RJ, Rodrigues GOL, Wu X, Back T, Czarra K, Michael H, Cam M, Chen J, Esposito D, Senkevitch E, Negi V, Aplan PD, Li W, Durum SK
Leukemia. 32(8): 1795-1882, 2018. [ Journal Article ]

HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127

Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.
AIDS. 27: 1867-77, 2013. [ Journal Article ]

Job Vacancies

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Team

Special Volunteer
Caroline Andrews, D.V.M.
Biological Laboratory Technician
Julie Hixon, M.S.
Postdoctoral Fellow (CRTA)
Tu Chun Hsu, D.V.M.
Postdoctoral Fellow (Visiting)
Gisele Olinto Libanio Rodrigues, Ph.D.
Research Fellow
Hila Winer Yanai, Ph.D.