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Hiroshi Matsuo, Ph.D.

Hiroshi Matsuo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. Matsuo has combined structural biology with molecular biology to study functional mechanisms of biomolecules. The biological systems that he chose to study were challenging and required the development of new techniques to answer the scientific questions that he was probing. For example, the structure of λ-phage Cro was among the first homo-dimers to be determined by NMR, the eIF4E-m7GDP complex structure was the first solved in a detergent micelle by solution NMR, and APOBEC3G was not amenable for structural study before his group overcame its insolubility. Dr. Matsuo plans to keep challenging the limits of structural biology to study biological systems that are important for human health.
 

Areas of Expertise

1) structural biology 2) nuclear magnetic resonance (NMR) 3) protein-protein interaction 4) protein-DNA, protein-RNA interaction 5) protein, DNA and RNA structure

Publications

Selected Key Publications

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

Maiti A, Myint W, Kanai T, Delviks-Frankenberry K, Sierra Rodriguez C, Pathak VK, Schiffer CA, and Matsuo H.
Nature Communications. 9(1): 2460, 2018. [ Journal Article ]

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Yilmaz NK, Matsuo H and Schiffer CA.
Nature Communications. 8: 15024, 2017. [ Journal Article ]

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

Kouno T, Luengas E.M, Shigematsu M, Shandilya SM, Zhang J, Chen L, Hara M, Schiffer CA, Harris RS, and Matsuo H.
Nat Struct Mol Biol. 22(6): 485-91, 2015. [ Journal Article ]

Structure of the RNA claw of the DNA packaging motor of bacteriophage phi29

Harjes E, Kitamura A, Zhao W, Morais M, Jardine P.J, Grimes S and Matsuo H.
Nucleic Acids Res. 40(19): 9953-9963, 2012. [ Journal Article ]

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Chen K-M, Harjes E, Gross P.J, Fahmi A, Lu Y, Shindo K, Harris R.S and Matsuo H.
Nature. 452: 116-119, 2008. [ Journal Article ]

Job Vacancies

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Team

Research Technician (Leidos)
Tapan Kanai
Scientist I (Leidos)
Atanu Maiti, Ph.D.
Scientist I (Leidos)
Wazo Z. Myint, Ph.D.
Research Technician (Leidos)
Christina L. Sierra
Postdoctoral Fellow (Leidos)
Kate Skorupka, Ph.D.