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Howard A. Young, Ph.D.

Howard A. Young, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory's major focus was investigating how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory developed a mouse model of chronic interferon-gamma expression that results in at least three different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.

Areas of Expertise

Cancer Immunology and Immunotherapy | Interferon Biology | Cytokine Gene Expression | Interferon-Gamma | Autoimmunity

Publications

Selected Key Publications

Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases.

Bae HR, Leung PSC, Hodge DL, Fenimore JM, Jeon SM, Thovarai V, Dzutsev A, Welcher AA, Boedigheimer M, Damore MA, Choi MS, Fravell RA, Trinchieri G, Gershwin ME, Young HA.
Journal of Autoimmunity. 111: 102436, 2020. [ Journal Article ]

The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity

Bae HR, Hodge DL, Yang GX, Leung PSC, Chodisetti SB, Valencia JC, Sanford M, Fenimore JM, Rahman ZSM, Tsuneyama K, Norman GL, Gershwin ME, Young HA.
Hepatology. 67: 1408-1419, 2018. [ Journal Article ]

Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance

Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, Back T, Karwan M, Merchant AS, Baba N, Feng D, Park O, Gao B, Yang GX, Gershwin ME, Young HA.
Hepatology. 64: 1189-1204, 2016. [ Journal Article ]

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Salerno F, Guislain A, Freen-Van Heeren JJ, Nicolet BP, Young HA, Wolkers MC.
Oncoimmunology. 8(2): e1532762, 2018. [ Journal Article ]

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
J. Autoimmunity. 53: 33-45, 2014. [ Journal Article ]