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Vineet N. KewalRamani, Ph.D.

Vineet N. KewalRamani, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. KewalRamani has made significant advances in illuminating the role of host factors in HIV infection and the biology of HIV in animal models. Under his direction, the Model Development Section (MDS) examines virus-host interactions at molecular, cellular, and animal levels to better understand HIV immunopathogenesis and the development of antiviral resistance. Current projects in the MDS include (1) understanding how HIV-1 exploits cell biological mechanisms to further virus replication, (2) identification of innate intracellular mechanisms that counteract HIV-1 replication, and (3) the development of improved nonhuman primate models to study HIV-1 pathogenesis and persistence.

Areas of Expertise

Virus-Host Interactions
Cofactors in HIV Infection
Animal Models for HIV Infection
HIV Pathogenesis

Publications

Selected Key Publications

HIV-1-induced AIDS in monkeys

Hatziioannou T, Del Prete GQ, Keele BF, Estes JD, McNatt MW, Bitzegeio J, Raymond A, Rodriguez A, Schmidt F, Trubey CM, Smedley J, Piatak M, KewalRamani VN, Lifson JD, Bieniasz PD.
Science. 344: 1401-1405, 2014. [ Journal Article ]

Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host

Schmidt F, Keele BF, Del Prete GQ, Voronin D, Fennessey CM, Soll S, Kane M, Raymond A, Gifford RJ, KewalRamani V, Lifson JD, Bieniasz PD, Hatziioannou T.
Proc Natl Acad Sci U S A. 116(21): 10504-9, 2019. [ Journal Article ]

A single gp120 residue can affect HIV-1 tropism in macaques

Del Prete GQ, Keele BF, Fode J, Thummar K, Swanstrom AE, Rodriguez A, Raymond A, Estes JD, LaBranche CC, Montefiori DC, KewalRamani VN, Lifson JD, Bieniasz PD, Hatziioannou T.
PLoS Pathog. 13(9): e1006572, 2017. [ Journal Article ]

STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG.
Science. 349(6243): 99-103, 2015. [ Journal Article ]

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins

Del Prete GQ, Ailers B, Moldt B, Keele BF, Estes JD, Rodriguez A, Sampias M, Oswald K, Fast R, Trubey CM, Chertova E, Smedley J, LaBranche CC, Montefiori DC, Burton DR, Shaw GM, Markowitz M, Piatak M Jr, KewalRamani VN, Bieniasz PD, Lifson JD, Hatziioannou T.
Cell Host Microbe. 16(3): 412-8, 2014. [ Journal Article ]

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Team

Postdoctoral Fellow (Visiting)
Szu-Wei Huang, Ph.D.
Special Volunteer
Ya-Chuan Huang
Scientist II (Contr.)
Hyun Jae Yu, Ph.D.
Postbaccalaureate Fellow
Christopher Raddatz
Postbaccalaureate Fellow
Stephanie Suinn

News

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