Frank J. Gonzalez, Ph.D.

Frank J. Gonzalez, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory


Dr. Gonzalez’s research focuses on investigating the mechanisms of chemical carcinogenesis using various mouse bioassays for colon, liver, mammary and other cancers. His work includes the study of signal transduction pathways involving nuclear receptors and their role in cancer initiation and progression. He extensively uses genetically engineered mouse models. Metabolomics, using liquid chromatography-mass spectrometry technology, is employed to discover early biomarkers for cancer and to explore cancer mechanisms. His group also studies the etiology and treatment of metabolic diseases such as obesity and insulin resistance that lead to increased risk or cancer.

Areas of Expertise


Selected Publications

Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression.

Yan T, Yan N, Xia Y, Sawaswong V, Zhu , Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotma, Y, Qu A, Hao H, Gonzalez FJ
Journal of Clinical Investigation. 134(7):e166731: 2024. [ Journal Article ]

Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer

Sun L, Zhang Y, Cai J, Rimal B, Rocha, ER, Coleman JP, Zhang C, Nichol, RG, Luo Y, Kim B, Chen Y, Krausz KW, Harris CC, Patterson AD, Zhang Z, Takahashi S, Gonzalez FJ
Nature Communications. 14: 755, 2023. [ Journal Article ]

Gut bacteria alleviate nicotine-accelerated NASH by degrading intestinal nicotine

Chen B, Sun L, Zeng G, Shen Z., Wang K, Yi L, Xu F, Wang P, Ding Y, Nei Q, Wu Q, Zhang Z, Xia J, Lin J, Luo Y, Cai J, Krausz KW, Zheng R, Xue Y, Zheng M, Li Y, Yu C, Gonzalez F.J, Jiang C.
Nature. 610: 562-568, 2022. [ Journal Article ]

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Chen L, Jiao T, Liu W, Luo Y, Wang J, Guo X, Tong X, Lin Z, Sun C, Wang K, He Y, Zhang Y, Xu H, Wang J, Zuo J, Ding Q, He S, Gonzalez FJ, Xie C
Cell Stem Cell. 29(9): 1366-1381, 2022.
Full-Text Article
[ Journal Article ]

Microbial-host-isozyme analyses reveal microbial DPP4 inhibition as a potential antidiabetic target

Wang K, Zhang Z, Hang J, Liu J, Guo F, Ding Y, Li M, Nie Q, Lin J, Zhuo Y, Sun L, Zhong Q, Ye C, Yu C, Zhang Y, Wang J, Bao R, Pang Y, Wang G, Gonzalez FJ, Lei X., Qia, J, Jiang C.
Science. 381/6657: 2023. [ Journal Article ]

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Technical Lab Manager
Kristopher Krausz, B.S.
Staff Scientist
Shogo Takahashi, Ph.D.
Research Fellow
Yangliu Xia, Ph.D.
Postdoctoral Fellow (Visiting)
Bora Kim, Ph.D.
Predoctoral Fellow, GPP Student (Visiting)
Nana Yan, M.S.
Predoctoral Fellow, GPP Student (Visiting)
Yoshifumi Saito, M.S.
Predoctoral Fellow, GPP Student (Visiting),
Xiaoting Yu, M.S.
Postdoctoral Fellow (Visiting)
Carlos Ichiro Kasano Camones , Ph.D.
Postdoctoral Fellow (Visiting)
Ming Qi, Ph.D.
Postdoctoral Fellow (Visiting)
Xiaoyan Liu, Ph.D.