Frank J. Gonzalez, Ph.D.

Frank J. Gonzalez, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory


Dr. Gonzalez’s research focuses on investigating the mechanisms of chemical carcinogenesis using various mouse bioassays for colon, liver, mammary and other cancers. His work includes the study of signal transduction pathways involving nuclear receptors and their role in cancer initiation and progression. He extensively uses genetically engineered mouse models. Metabolomics, using liquid chromatography-mass spectrometry technology, is employed to discover early biomarkers for cancer and to explore cancer mechanisms. His group also studies the etiology and treatment of metabolic diseases such as obesity and insulin resistance that lead to increased risk or cancer.

Areas of Expertise

1) nuclear receptor signaling, 2) metabolomics, 3) metagenomics, 4) metabolic diseases,
5) mechanisms of carcinogenesis 


Selected Publications

Gut bacteria alleviate nicotine-accelerated NASH by degrading intestinal nicotine

Chen B, Sun L, Zeng G, Shen Z., Wang K, Yi L, Xu F, Wang P, Ding Y, Nei Q, Wu Q, Zhang Z, Xia J, Lin J, Luo Y, Cai J, Krausz KW, Zheng R, Xue Y, Zheng M, Li Y, Yu C, Gonzalez F.J, Jiang C.
Nature. 610: 562-568, 2022. [ Journal Article ]

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal

Chen L, Jiao T, Liu W, Luo Y, Wang J, Guo X, Tong X, Lin Z, Sun C, Wang K, He Y, Zhang Y, Xu H, Wang J, Zuo J, Ding Q, He S, Gonzalez FJ, Xie C
Cell Stem Cell. 29(9): 1366-1381, 2022.
Full-Text Article
[ Journal Article ]

Intestinal MYC modulates obesity-related metabolic dysfunction

Luo Y, Yan S, Wu X, Takahashi S, Sun L, Cai J, Krausz KW, Guo X, Gavrilova O, Xie C, Jiang C, Liu W, Gonzalez FJ
Nature Metabolism. 3(7): 923-939, 2021. [ Journal Article ]

MYC-protein arginine methyltransferase 5 axis defines the tumorigenesis and immune response in hepatocellular carcinoma

Luo Y, Gao Y, Liu W, Yang Y, Wang Y, Tang W, Yang S, Sun L, Cai J, Guo X, Takahashi S, Krausz KW, Qu A, Chen L, Xie C, Gonzalez FJ
Hepatology. 74(4): 1932-1951, 2021. [ Journal Article ]

Intestinal PPARα protects against colon carcinogenesis via regulation of methyltransferases DNMT1 and PRMT6

Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology. 157(3): 744-759, 2019. [ Journal Article ]

Job Vacancies

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Research Geneticist
Linda Gail Byrd, Ph.D.
Technical Lab Manager
Kristopher Krausz, B.S.
Postdoctoral Fellow (Visiting)
Yuhong Luo, M.D., Ph.D.
Postdoctoral Fellow (Visiting)
Lulu Sun, M.D., Ph.D.
Staff Scientist
Shogo Takahashi, Ph.D.
Postdoctoral Fellow (Visiting)
Tingting Yan, Ph.D.
Postdoctoral Fellow (Visiting)
Bora Kim, Ph.D.
Predoctoral Fellow, GPP Student (Visiting)
Nana Yan, M.S.
Research Fellow
Yangliu Xia, Ph.D.
Special Volunteer
Vorthon Sawaswong, M.S.
Predoctoral Fellow, GPP Student (Visiting)
Yoshifumi Saito, M.S.